The active components, targets, and pathways of
Euphorbia fischeriana Steud.-Jujubae Fructus in treating hepatocirrhosis
and the mechanism of action were explored by means of network
pharmacology. Firstly, the active components and related targets of
Jujubae Fructus were screened by TCMSP database and standardized by
Uniprot database. The compounds of Euphorbia fischeriana Steud. were
obtained by searching the literature and finally screened by PubChem
database, Swiss ADME, and SwissTargetPrediction. Hepatocirrhosis targets
were obtained through Genecards database, PPI network analysis was
conducted on common targets of Euphorbia fischeriana Steud.-Jujubae
Fructus and hepatocirrhosis by using String database, GO enrichment
analysis and KEGG pathway enrichment analysis was conducted through
Metascape database by using intersection targets of Euphorbia
fischeriana Steud.-Jujubae Fructus and hepatocirrhosis, and the results
were drawn by using Weishengxin online drawing platform. Then, the
network of drug-compound-target-pathway was constructed by the software
of Cytoscape3.8.0. Finally, the above results were verified by molecular
docking. 47 active compounds from Euphorbia fischeriana Steud.-Jujubae
Fructus were screened out, which had 38 common targets, 162 intersection
targets, and 340 signal pathways with hepatocirrhosis, mainly involving
hepatitis C, JAK-STAT signal pathway and AGE-RAGE signal pathway.
Targets, such as MAPK1, AKT1, TNF, JUN, IL6 and PTGS2, play important
roles in the treatment. The findings suggested that the main active
ingredients of Euphorbia fischeriana Steud.-Jujubae Fructus in treating
hepatocirrhosis are quercetin, scopolamine, physcion, 7-deoxyrangduin,
17-Hydroxyjolkinolide A, etc. Molecular docking results showed that the
main active components and core targets might have a good binding
capacity. This study preliminarily explored the potential mechanism of
Euphorbia fischeriana Steud.-Jujubae Fructus in treating hepatocirrhosis
and provided a theoretical basis for the clinical application of
Euphorbia fischeriana Steud.-Jujubae Fructus.
