Asian Journal
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Analysis and insights into the changes of traditional Chinese medicine review and approval from 2020 to 2024 Wenli Li, Qian Sun, Wenxia Ding Asian Journal of Traditional Medicines    2025, 20 (4): 181-194.   Abstract （188）      PDF（pc） （1354KB）（3334）       Knowledge map    Save The official release of the “Drug Registration Management Measures” in January 2020 marked a new milestone in the  classification management of traditional Chinese medicine (TCM) registration, ushering in a new era for the registration and  application of innovative TCM drugs. This article provides a detailed analysis of the approval status of innovative TCM drugs,  improved new drugs, and ancient classic prescription compound preparations from 2020 to 2024, revealing the significant  achievements made in the inheritance and innovation of TCM in China. The study found that the number of New Drug  Applications (NDAs) and Investigational New Drug Applications (INDs) have increased annually, with a particularly notable  surge in the submission of applications for classic prescription compound preparations. The approval rates for innovative  TCM drugs and improved new drugs have significantly increased, along with the streamlining of review and approval process,  leading to shorter development cycles and reduced costs. Key findings include: (1) Enterprises demonstrate strong enthusiasm  for the research and development of innovative and improved TCM drugs, actively engaging in various types of drug R&D and  submissions; (2) Classic prescription compound preparations have become a focal point for enterprises due to their shorter  development cycles and lower costs; (3) Improvement to the “three-combined” evidence system has accelerated the R&D process  by incorporating real-world data. Through this study, we aim to provide valuable insights for TCM R&D enterprises and  policymakers, promoting the sustained prosperity and development of the TCM sector. Related Articles | Metrics | Comments（0）

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Research progress on hepatotoxicity and toxicity reduction of Toosendan Fructus Xiaoyu Jiang, Yiduo Zhu, Mengwen Shang, Jun Yin, Zhihui Liu Asian Journal of Traditional Medicines    2025, 20 (5): 226-237.   Abstract （44）      PDF（pc） （2302KB）（629）       Knowledge map    Save This study reviews the hepatotoxic chemicals, mechanisms of toxicity, and detoxification methods of Toosendan Fructus (TF). Limonin-type triterpenoids, as primary hepatotoxic components, mediate toxicity though inflammation, oxidative stress, mitochondrial dysfunction, ferroptosis, and apoptosis. Hepatotoxicity can be mitigated by controlling dosage, using processed forms of the herbs, and through rational herbal compatibility. The review provides insights for enhancing the safety and clinical application of TF. Related Articles | Metrics | Comments（0）

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Chemical composition and pharmacological effects of the  Forsythia suspensa Jiayuan Wang, Zixuan Che, Yuzheng Xiang, Meng Zhang, Ying Li, Yu Chen Asian Journal of Traditional Medicines    2026, 21 (1): 42-57.   Abstract （71）      PDF（pc） （1744KB）（410）       Knowledge map    Save The dried fruit of Forsythia suspensa (Oleaceae), also known as Forsythia, is a traditional Chinese medicinal herb known for its  heat-clearing and detoxifying properties. It is used to disperse nodules, reduce swelling, remove toxins, clear heat, and alleviate  wind-heat syndromes. It also has hepatoprotective, anti-inflammatory, antiviral, antibacterial, anticancer, antioxidant, anti-aging, and anti-obesity effects, as well as potential therapeutic effects on Alzheimer’s disease and diabetic nephropathy. It is used  to treat scrofula, mastitis, wind-heat common cold, and other ailments. The review summarizes the chemical constituents and  pharmacological effects of F. suspensa, aiming to provide a scientific foundation for its future development, research, and clinical  utilization. Related Articles | Metrics | Comments（0）

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Mechanisms and preliminary validation of luteolin in the treatment of hyperuricemia based on network pharmacology and toxicology studies Yulin Hong† , Xinhui Yang† , Zhenyu Liu, Yizhen Chen, Yunkun Zhang, Xin Wu Asian Journal of Traditional Medicines    2025, 20 (4): 161-172.   Abstract （162）      PDF（pc） （2310KB）（126）       Knowledge map    Save Hyperuricemia (HUA) refers to a condition where fasting serum uric acid levels exceed 420 μmol/L in men and 350 μmol/L in women, affecting 17.4% of China’s general population, showing increasing prevalence among younger individuals. Luteolin, a common flavonoid compound, exhibits multiple biological effects, including inhibition of tumor proliferation and inflammatory responses. It also suppresses the activity of urate transporter 1 (URAT1), promoting uric acid excretion. This study is the first to integrate network toxicology and network pharmacology approaches to systematically analyze the multi-target mechanisms of adenine-induced HUA and luteolin-treated HUA, with molecular docking validation of interaction targets. We constructed compound-pathway-intersection gene networks and a dual-group PPI network to analyze the mechanisms of adenine-induced HUA and luteolin-treated HUA. The dual-group PPI network identified 7 shared targets, namely XDH, PYGL, IL10, PPARG, TNF, VEGFA, and MAOA, involving core intersecting pathways such as purine-xanthine metabolism and insulin resistance. Luteolin may activate PPARG to regulate inflammation and uric acid excretion modules in the adenine network. GO-KEGG analysis indicates that intersection genes for adenine pathogenesis involve diverse biological processes, cellular components, and molecular functions, with core target KEGG analysis revealing 15 signaling pathways. Luteolin’s therapeutic targets are associated with more entries, and its core target KEGG analysis identified 46 signaling pathways. Molecular docking shows TNF, PPARG, and PYGL bind to both luteolin and adenine with negative binding energies, and luteolin’s binding energies are all below 5 kJ/mol, confirming stable binding. Luteolin’s anti-HUA mechanism is characterized by inhibition of production, promotion of excretion, anti-inflammation and metabolic regulation, but interactions with gut microbiota metabolites require further study. Related Articles | Metrics | Comments（0）

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Phytochemical investigation of the branches of Viburnum awabuki K. Koch and its chemotaxonomic significance Sidie Li†, Ningning Du†, Qi Song, Xiaoxiao Huang, Shaojiang Song Asian Journal of Traditional Medicines    2025, 20 (5): 213-225.   Abstract （60）      PDF（pc） （2390KB）（118）       Knowledge map    Save Phytochemical investigation of the branches of Viburnum awabuki K. Koch led to the isolation of thirteen known compounds, including five lignans (1-5), one phytosterol (6), two phenylpropanoids (7-8), one chromone derivative (9), three pentacyclic triterpenoids (10-12), and one glyceride (13). The structures of these compounds were elucidated through extensive spectroscopic analyses and comparison of experimental data with literature data. Additionally, the chemotaxonomic significance of the isolated secondary metabolites was also discussed. Related Articles | Metrics | Comments（0）

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A matrine-oxymatrine in-situ gel for the treatment of allergic rhinitis Peng Wu, Di Feng, Hongjian Wang, Shilin Li, Linghe Zang, Nan Liu, Yilin Wang, Dongchun Liu, Xing Tang Asian Journal of Traditional Medicines    2025, 20 (6): 253-270.   Abstract （59）      PDF（pc） （14993KB）（109）       Knowledge map    Save Sophorae Flavescentis Radix (Ku Shen) is a traditional Chinese medicine used to treat damp-heat syndrome-related diseases, such as  dysentery, jaundice, rhinitis, and skin inflammation. Recent studies have revealed the potential pharmacological value of its active  alkaloid components, matrine (MAT) and oxymatrine (OMT), in the treatment of allergic rhinitis (AR). To develop a thermosensitive  in-situ gel containing MAT and OMT for the intranasal treatment of AR, a thermosensitive matrix composed of Pluronic F127/ F68 was optimized using the Box–Behnken Response Surface Methodology. The biosafety of the formulation was evaluated using  a palatal ciliary movement model. A guinea pig model of AR induced by ovalbumin and aluminum hydroxide was established.  Pharmacodynamic effects were comprehensively assessed through behavioral scoring, histopathological analysis (hematoxylin and  eosin) of nasal mucosa, and serum immunological markers (IgE, IL-4, and IFN-γ). The MAT-OMT in-situ gel showed no toxicity during  ciliary movement in the toad palatal ciliary motility model. The MAT-OMT combination significantly alleviated nasal itching, sneezing,  and rhinorrhea in guinea pigs with AR, mitigated mucosal edema and epithelial damage, and improved inflammatory cytokine levels,  suggesting its efficacy in correcting Th1/Th2 immune imbalance. The comprehensive therapeutic effect of MAT-OMT was significantly  superior to that of MAT or OMT alone and comparable to that of the positive control, budesonide. Related Articles | Metrics | Comments（0）

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Synergistic action of the Daphnes Cortex and Liquorice Root herb pair in rheumatoid arthritis treatment: A network  pharmacology strategy Wanying Ma, Yuanqing Li, Simeng Ding, Guodong Yao Asian Journal of Traditional Medicines    2026, 21 (1): 1-14.   Abstract （64）      PDF（pc） （13606KB）（108）       Knowledge map    Save The combination of Daphnes Cortex (DC) and Liquorice Root (LR), two traditional Chinese medicinal herbs, has shown significant therapeutic effects on rheumatoid arthritis (RA), but its synergistic mechanism of action remains to be elucidated. Employing a network pharmacology and molecular docking approach, this study systematically investigated the synergistic mechanism of the herb pair DC and LR in RA treatment. Active components and their corresponding targets were retrieved from the TCMSP database and relevant literature, and RA-related targets were collected from established disease databases. A total of 73 overlapping targets between DC-LR and RA were identified, among which core targets such as AKT1, TNF, and CASP3 were highlighted. GO and KEGG enrichment analyses revealed that these targets are involved in biological processes such as oxidative stress response and cell migration, and are significantly enriched in key pathways including HIF-1, TNF, and PI3K-Akt signaling pathways. Compatibility analysis further revealed that the combination of DC and LR may enhance therapeutic effects through synergistic regulation of shared targets and complementary modulation of upstream and downstream pathway components. Molecular docking confirmed strong binding affinities between core active components and key targets. This study provides a multi-dimensional “component-target-pathway” perspective on the potential synergistic anti-RA mechanism of the DC-LR herb pair, offering a theoretical basis for further experimental validation and clinical application. Related Articles | Metrics | Comments（0）

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Chemical composition and biological activities of Angelica sinensis Jiankun Jin, Zixuan Che, Rui Liu, Ruiqi Ma, Ying Li, Meng Zhang, Yu Chen Asian Journal of Traditional Medicines    2025, 20 (6): 285-296.   Abstract （84）      PDF（pc） （5798KB）（104）       Knowledge map    Save Angelica sinensis (A. sinensis), as a kind of Chinese medicine, has the effects of tonifying blood, promoting blood circulation, regulating menstrual flow, relieving pain, moistening bowel and so on. By consulting Sciencedirect database and Web of Science database, 163 related articles were found, of which 36 were related to chemical composition and pharmacological activities of A. sinensis. In this paper, the chemical structures and different derivatives were systematically summarized by reviewing relevant literatures, and the pharmacological effects were also summarized. Related Articles | Metrics | Comments（0）

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Application of molecular identification techniquesin traditional Chinese medicine Jiankun Jin, Weiwei Zhang, Rui Liu, Ruiqi Ma, Yuzheng Xiang, Yibo Wang, Ying Li, Yu Chen Asian Journal of Traditional Medicines    2025, 20 (4): 173-180.   Abstract （140）      PDF（pc） （1703KB）（101）       Knowledge map    Save In recent years, molecular identification technology has become the predominant approach for the identification of traditional Chinese medicine. The molecular identification techniques in recent years were analyzed and summarized in this paper, such as RAPD, ISSR, RFLP, AFLP, SNP, and DNA bar code sequence analysis techniques. By consulting Sciencedirect databases and Web of Science databases, 2348 related articles were found, of which 39 were related to molecular identification techniques and traditional Chinese medicine. The application of the molecular identification techniques in four aspects was reviewed, namely the identification on the authenticity (true or false), multi-source identification and genetic diversity, producing area, and growing year discrimination of traditional Chinese medicine. Related Articles | Metrics | Comments（0）

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Study on the mechanism of Zedoary turmeric oil combined with docetaxel in the treatment of breast cancer based on network pharmacology and molecular docking technolog Yujiao Hou, Jian Wang, Bo Hong, Yuesheng Zhao, Jun Liu, Yanan Bao, Wenjing Li Asian Journal of Traditional Medicines    2025, 20 (6): 271-284.   Abstract （53）      PDF（pc） （14493KB）（79）       Knowledge map    Save In order to reveal the multi-target pharmacological mechanism of Zedoary turmeric oil combined with docetaxel in the treatment of breast cancer, we used network pharmacology and molecular docking. The targets of docetaxel were retrieved from the Swiss Target Prediction database. The active components of Curcuma Zedoary turmeric were screened using the Traditional Chinese Medicine Systems Pharmacology Database and Analysis Platform (TCMSP), with criteria set as oral bioavailability OB ≥ 30% and drug-likeness DL ≥ 0.1. Potential targets of these components were subsequently predicted. Breast cancer-related targets were retrieved from the OMIM and GeneCards databases. The Venny tool was used to identify 177 overlapping targets between docetaxel, Zedoary turmeric oil, and breast cancer, followed by protein-protein interaction (PPI) analysis. Gene Ontology (GO) functional enrichment and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analyses were performed using the Metascape database. A drug-breast cancer-KEGG pathway target network was constructed using Cytoscape 3.8.0. Molecular docking was employed to verify the binding ability between drugs and core targets. Results showed that the combined treatment may exert anti-breast cancer effects through key targets such as MAPK1, PIK3CA, and HSP90AA1, primarily implicating the biological process of protein phosphorylation and engaging the PI3K-Akt signaling pathway. This study successfully predicted the key targets and enriched pathways of Zedoary turmeric oil combined with docetaxel for breast cancer treatment, providing new insights for further research and development. Related Articles | Metrics | Comments（0）

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A review of compounds with anti-hepatoma properties in Glycyrrhiza uralensis Xijie Wang, Ran Guo, Jiankun Jin, Zixuan Che, Meng Zhang, Ying Li, Yu Chen Asian Journal of Traditional Medicines    2025, 20 (6): 297-306.   Abstract （35）      PDF（pc） （2523KB）（75）       Knowledge map    Save Hepatoma, one of the most common fatal malignant tumors, exhibits a rising global incidence, especially in developing countries. In recent years, traditional Chinese medicine has played an increasingly significant role in hepatoma treatment. Glycyrrhiza uralensis (G. uralensis), a perennial herb in the legume family, is also known as G. uralensis, sweet root, sweet grass, and ancient Chinese grass. Its roots and rhizomes are used medicinally for their properties to nourish Qi, detoxify, and harmonized the effects of various compounds. This study selected “Glycyrrhiza”, “hepatoma”, and “pharmacological effect” as key search terms. From PubMed, a total of 2,947 articles were retrieved containing these keywords in either the abstract or title, among which 12 were relevant to Glycyrrhiza and hepatoma. Additionally, from the Wanfang database, 19,632 papers were retrieved with “Glycyrrhiza” in the abstract or title, among which 197 were related to Glycyrrhiza and hepatoma. This review focuses on the anti-hepatoma properties of Glycyrrhiza, providing a comprehensive overview of its common extracts, such as flavonoids, triterpenoids, and polysaccharides, and elaborating on their chemical structures, anti-hepatoma cancer mechanisms, and other pharmacological effects. Related Articles | Metrics | Comments（0）

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Applications of capillary electrophoresis in traditional Chinese medicine Xinyi Zhang, Jiankun Jin, Zixuan Che, Rui Liu, Ying Li, Meng Zhang, Yu Chen Asian Journal of Traditional Medicines    2025, 20 (5): 238-247.   Abstract （60）      PDF（pc） （812KB）（68）       Knowledge map    Save Capillary electrophoresis (CE), recognized for its minimal reagent dosage, rapid analysis, and high efficiency, holds significant promise for the analysis of traditional Chinese medicines (TCM). This article reviews the application of CE in the determination of active ingredients in TCM. The active substances of herbal medicines have been classified and discussed based on their chemical properties, and the CE methods applied to different substances are summarized and discussed. This article also provides some suggestions for future research and improvement. Related Articles | Metrics | Comments（0）

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Research progress of chemical composition and pharmacological  activity of Boenninghausenia sessilicarpa Lévl. Shuxing Tian, Lan Zou, Yue Yang, Qiaoyan Yang, Fayun Zi, Pan Zhang Asian Journal of Traditional Medicines    2025, 20 (4): 195-207.   Abstract （93）      PDF（pc） （3167KB）（64）       Knowledge map    Save Boenninghausenia sessilicarpa Lévl. is a commonly used folk medicine in southwest Yunnan. It has the effects of clearing heat  and detoxifying, promoting qi circulation and activating blood circulation. It is used to treat various conditions such as colds,  tonsillitis, mumps, lung-heat induced cough and asthma, abdominal distension and pain, pyelonephritis, gangrene of the  extremities, low back pain, and bruises from falls and injuries. This paper summarizes recent research progress on the chemical  constituents and pharmacological activities of Boenninghausenia sessilicarpa Lévl., aiming to advance fundamental and clinical  studies on this plant and provide a reference for enhanced medical utilization. Related Articles | Metrics | Comments（0）

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The mechanism of Huangqi Guizhi Decoction in improving pulmonary embolism based on network pharmacology and molecular docking technology Yiting Wang, Bo Hong, Yanan Bao, Huan Cong, Jiawen Liu, Dan Zeng, Wenjing Li Asian Journal of Traditional Medicines    2026, 21 (1): 15-30.   Abstract （49）      PDF（pc） （9668KB）（51）       Knowledge map    Save This study explored the therapeutic targets and molecular mechanisms of Huangqi Guizhi Decoction (HGD) in alleviating  pulmonary embolism (PE) by employing network pharmacology and molecular docking techniques. Firstly, the effective active  components of the Chinese herbs in HGD were retrieved from the Traditional Chinese Medicine Systems Pharmacology Database  (TCMSP), and their potential therapeutic targets were predicted using the Swiss Target Prediction platform. Subsequently, PErelated target genes were obtained from the Online Mendelian Inheritance in Man (OMIM) database and GeneCards database.  Then, the Wei Sheng Xin tool was used to generate a Venn diagram for identifying the common targets between the herb-related  targets and PE-related targets. After screening these common targets, a “drug-component-target network” and a protein-protein  interaction (PPI) network were constructed. Furthermore, Gene Ontology (GO) enrichment analysis and Kyoto Encyclopedia of  Genes and Genomes (KEGG) enrichment analysis were conducted on the intersecting targets, and molecular docking verification  was performed using AutoDockTools and PyMol software. Finally, 20 active components were screened from Astragali Radix, 7  from Cinnamomi Ramulus, 13 from Paeoniae Radix Alba, 5 from Zingiberis Rhizoma Recens, and 29 from Jujubae Fructus, with  a total of 983 therapeutic targets. Among these targets, 134 were associated with PE, and protein kinase B1 (AKT1), mitogen-activated protein kinase 1 (MAPK1), and transformation-related protein 53 (TP53) served as the core targets. The results of GO  and KEGG enrichment analyses indicated that the alleviation of PE by HGD is mainly related to pathways including immune  response, regulation of gene expression, atherosclerosis, and tumorigenesis. Molecular docking results showed that the key  active components in HGD could bind to the core targets spontaneously and stably. This study revealed that HGD may alleviate  symptoms in PE patients by regulating signaling pathways, modulating platelet function to exert anticoagulant effects, and  regulating the expression of anti-inflammatory genes, which provided a direction for subsequent experimental research. Related Articles | Metrics | Comments（0）

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Study on the mechanism of Curcuma zedoaria in breast cancer based on network  pharmacology Yanqiong Luo, Dan Zeng, Zhaohan Wang, Jiawen Liu, Bo Hong, Wenjing Li Asian Journal of Traditional Medicines    2026, 21 (2): 84-99.   Abstract （20）      PDF（pc） （7154KB）（36）       Knowledge map    Save This study explored the anti-breast cancer (BC) mechanism of Curcuma zedoaria (CZ) via the network pharmacology approach.  The active components of CZ were screened by oral bioavailability (OB) and drug-likeness (DL) criteria using the Traditional  Chinese Medicine Systems Pharmacology Database and Analysis Platform (TCMSP). The potential targets of CZ were predicted through TCMSP and SwissTargetPrediction, while BC-related target genes were screened via GeneCards and the Online  Mendelian Inheritance in Man (OMIM) database. The common target genes of CZ and BC were obtained by using the Venn tool.  The protein interaction network diagram was constructed by using String software. The network diagram of CZ components was  created by using Cytoscape 3.8.0. The intersection genes of drugs and diseases were analyzed by using the R language software for Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analysis. Finally, the  docking activity between the active ingredient and the key target was verified through molecular docking. Through the methods  of database search and literature mining, 23 bio-active components of CZ and 370 corresponding gene targets, 1776 disease  gene targets, and 132 drug-disease intersection genes were obtained. GO analysis revealed 67 types of cellular components, 113  molecular functions, and 2042 biological processes. KEGG analysis identified 138 enriched pathways. This study preliminarily elucidated the potential mechanism underlying the therapeutic effect of CZ on BC.  Related Articles | Metrics | Comments（0）

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Chemical composition and biological activities of Panax notoginseng Yu Wang, Da Teng, Zixuan Che, Ran Guo, Meng Zhang, Ying Li, Yu Chen Asian Journal of Traditional Medicines    2026, 21 (1): 31-41.   Abstract （41）      PDF（pc） （3203KB）（34）       Knowledge map    Save Panax notoginseng (P. notoginseng), a valuable traditional Chinese medicine, is the dried root of plants in Acanthopanax  gracilistylus family, with the effect of dispersing blood stasis, eliminating swelling and relieving pain. With the development of  modern medicine, the active ingredients and mechanisms of P. notoginseng have been gradually revealed. The present paper  systematically reviews the chemical composition and biological activities of P. nologinseng, to provide a scientific basis and  reference for detailed research on P. nologinseng. Related Articles | Metrics | Comments（0）

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Network pharmacology-based exploration of the synergistic efficacy and detoxification mechanisms of Tripterygium wilfordii and Epimedium brevicornum in treating rheumatoid arthritis Yuhang Wang, Boyan Shen, Yuanqing Li, Guodong Yao Asian Journal of Traditional Medicines    2026, 21 (2): 63-83.   Abstract （20）      PDF（pc） （14881KB）（25）       Knowledge map    Save Rheumatoid arthritis (RA) is a chronic autoimmune disease with limited therapeutic options. The herbal compatibility of Tripterygium wilfordii Hook. f. (Leigongteng, LGT) and Epimedium brevicornum Maxim. (Yinyanghuo, YYH), widely used in Traditional Chinese  Medicine, has shown promising efficacy in RA treatment, yet its synergistic mechanisms and hepatoprotective effects remain unclear.  In this study, we systematically investigated the therapeutic and hepatotoxicity-attenuating mechanisms of LGT-YYH using integrated  network pharmacology and molecular docking approaches. Bioactive compounds and corresponding targets from LGT and YYH were retrieved from the TCMSP database, while RA- and hepatotoxicity-related targets were collected from public databases and  microarray datasets. Protein-protein interaction networks, hub protein targets identification, and functional enrichment analyses  revealed that 65 LGT and 26 YYH bioactive compounds collectively interact with 527 RA-related targets, with hub targets including  PTPN11, SRC, EGFR, MAPK1, and MAPK8 central to the therapeutic network. KEGG enrichment highlighted the MAPK signaling  pathway as a key mechanism of anti-RA activity. Furthermore, 243 targets were associated with LGT-induced hepatotoxicity, and YYH  components, particularly icariin, kaempferol, and epimedin B, exhibited binding to hepatotoxicity-related targets such as AKT1 and  ESR1, suggesting a hepatoprotective role via the AKT1-ESR1-Nrf2 axis. These findings indicate that LGT-YYH exerts synergistic anti-RA effects by modulating MAPK-related signaling while YYH components may mitigate LGT-induced hepatotoxicity, exemplifying the  TCM principle of enhancing therapeutic efficacy while reducing toxicity.  Related Articles | Metrics | Comments（0）

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Multi-target mechanisms of hypericin: A systematic elucidation of pharmacological activities and therapeutic potential Bohan Shen, Menglin Gu, Yujian Lin, Yumeng Wang, Dali Meng Asian Journal of Traditional Medicines    2026, 21 (2): 114-142.   Abstract （25）      PDF（pc） （6577KB）（21）       Knowledge map    Save Hypericin, a naturally occurring naphthodianthrone isolated from several species of the genus Hypericum, exhibits multiple  pharmacological properties through its unique ability to interact with diverse molecular targets. As a multi-target agent,  hypericin shows therapeutic potential in treating neurological disorders, viral infections, cancer, inflammatory-related diseases,  and dermatological conditions. Despite these advances, challenges such as poor bioavailability, phototoxicity, and an incomplete mechanistic understanding of multi-target synergies hinder its clinical translation. Recent strategies, including nanoformulations  to enhance solubility and combination therapies to optimize efficacy, demonstrate promise in overcoming these limitations. This  review systematically consolidates the pharmacological actions, molecular mechanisms, and therapeutic applications of hypericin  while highlighting future directions for precision multi-target drug development. Related Articles | Metrics | Comments（0）

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Chemical constituents and biological activities of Scutellaria barbata Xinyue Song, Yuzheng Xiang, Ran Guo, Meng Zhang, Ying Li, Yu Chen Asian Journal of Traditional Medicines    2026, 21 (2): 143-165.   Abstract （21）      PDF（pc） （9635KB）（18）       Knowledge map    Save Scutellaria barbata D.Don (S. barbata), is a perennial herb of Labiatae scutellaria, with a variety of chemical constituents and  biological activities. Its chemical constituents include terpenoids, flavonoids, polysaccharides, volatile compounds and trace  elements. Among the terpenoids, diterpenoids are abundant, particularly neocrotane diterpenoids. More than 70 flavonoids have  been identified as important pharmacological components and quality control markers. Polysaccharides play an important role in its anti-tumor efficacy. Volatile compounds have antibacterial effects, and trace elements are associated with active ingredients.  In terms of pharmacological activity, S. barbata exhibits anti-tumor, hepatoprotective, anti-inflammatory, immunomodulatory, antioxidant and antibacterial effects. This review aims to summarize the research progress of S. barbata and provide a theoretical  basis for its clinical application.  Related Articles | Metrics | Comments（0）

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The application of artificial intelligence technology in the field of Chinese herbal medicine Yu Wang, Xiangting Luo, Ran Guo, Jiankun Jin, Meng Zhang, Ying Li, Yu Chen Asian Journal of Traditional Medicines    2026, 21 (2): 166-172.   Abstract （13）      PDF（pc） （743KB）（9）       Knowledge map    Save Chinese herbal medicine is a precious legacy of traditional Chinese medicine with a long history. With the progress of science  and technology, artificial intelligence has emerged as a transformative force. It can replace the role of traditional production  line workers, and provide us with more economical solutions, more accurate data, more environmentally friendly products and  easier operation. This paper aims to systematically summarize the application of artificial intelligence technology in the research, production and clinical application of traditional Chinese herbal medicine. Related Articles | Metrics | Comments（0）

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Quantitative evaluation of traditional Chinese medicine registration management  policy texts based on the PMC index model Pan Chen, Shuling Wang Asian Journal of Traditional Medicines    2026, 21 (2): 100-113.   Abstract （23）      PDF（pc） （5461KB）（6）       Knowledge map    Save To systematically and quantitatively evaluate China’s national-level traditional Chinese medicine (TCM) registration  management policies, providing evidence for policy optimization. Eight core policy documents from 2008 to 2025 were selected.  Text mining was conducted using ROSTCM 6.0 software to construct the Policy Management Capability (PMC) index model,  which includes 9 primary and 31 secondary indicators. The PMC index for each policy was calculated, and a three-dimensional  surface plot was generated for visualization. The overall average PMC score was 6.19, with the quality distribution exhibiting a  “bottle-shaped” pattern. The “Drug Registration Management Measures” (2020) achieved the highest score of 7.50 (Excellent),  while some technical guidance documents scored below 5.4 (Unsatisfactory). The policies generally performed well in terms of operability and content coverage but were deficient in policy evaluation, hierarchical structuring, and innovation incentives. The TCM registration management policies demonstrate a robust framework with imbalanced details. Dynamic evaluation and incentives for innovation need enhancement. Recommendations include systematic optimization of the system through  improvements in post-market evaluation, enhanced incentive tools, and stronger policy coordination.  Related Articles | Metrics | Comments（0）