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    Comprehensive analysis of phenolic composition and antioxidant mechanisms in Gymnema sylvestre extracts using LC-MS and column chromatography
    Shengjie Hao, Yuxin Du, Jianglong He, Qian Li, Guilin Chen
    Asian Journal of Traditional Medicines    2024, 19 (4): 211-222.  
    Abstract102)      PDF(pc) (2668KB)(312)       Save
    Recent studies have highlighted the potential of plant extracts as therapeutic agents for managing oxidative stress and related  disorders. This study aims to elucidate the phenolic composition and antioxidant properties of Gymnema sylvestre extracts.  Ethanolic reflux extraction followed by column chromatography was employed to isolate phenolic compounds. The total phenolic  and flavonoid contents were quantified using the Folin–Ciocalteu and aluminum chloride colorimetric methods, respectively.  Antioxidant activities were assessed by DPPH, ABTS scavenging assays and the ferric reducing antioxidant power (FRAP) assay.  High-Performance Liquid Chromatography (HPLC) with a C18 column and Thermo TSQ Quantum Access Max (LC-MS) were  used to determine the levels of gymnemic acid and identify other potential phenolic compounds. The analysis revealed significant  antioxidant activities in the fractions. Fraction A showed the highest DPPH and ABTS scavenging activities, and Fraction C  demonstrated the highest ferric reducing power. LC-MS analysis identified several phenolic compounds, indicating that these  are major contributors to the antioxidant efficacy of the extract. This study provides a detailed phenolic profile and confirms the  strong antioxidant potential of Gymnema sylvestre leaf extract, supporting its therapeutic use and further investigation.
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    Exploring the molecular mechanism of Corydalis yanhusuo against prostate cancer based on network pharmacology and molecular docking validation
    Ying Zhu#, Junwei Lu#, Jumin Xie
    Asian Journal of Traditional Medicines    2024, 19 (5): 241-265.  
    Abstract88)      PDF(pc) (17701KB)(62)       Save
    The molecular mechanism underlying Corydalis Yanhusuo’s therapeutic potential in prostate cancer (PCa) treatment was  elucidated using network pharmacology and molecular docking. Nineteen active ingredients, 399 drug targets, 1790 disease  targets and 143 intersection targets were identified. Ten core targets were screened from the protein-protein interaction network.  Enrichment analysis revealed 133 GO terms and 114 KEGG pathways. Corydalis Yanhusuo may potentially treat prostate cancer  through pathways such as the Rap1 signaling pathway, phospholipase D signaling pathway, Ras signaling pathway, VEGF  signaling pathway and JAK-STAT signaling pathway. Significant differences in expression were observed for EGFR, PDGFRA,  PIK3CA, PIK3CD, PIK3CG and PIK3R1. Molecular docking and dynamics simulation analysis showed low binding energy  between active components and the six core genes of Corydalis Yanhusuo, indicating a favorable docking effect. This study shows  that Corydalis Yanhusuo exhibits promise in prostate cancer treatment through a synergistic “multi-component-multi-targetmulti-pathway” effect.
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    The mechanism analysis of KangBingDuKouFuYe in treating throat infection based on network pharmacology and molecular docking
    Ying Long# , Xinhui Yang# , Hongfei Lv, Zhenyu Liu, Tianjun Guo, Chaohui Yang, Hui Liu, Qijia Yang, Xin Wu
    Asian Journal of Traditional Medicines    2025, 20 (1): 1-13.  
    Abstract86)      PDF(pc) (14358KB)(300)       Save
    KangBingDuKouFuYe (KBDKFY) is widely used to treat inffuenza, upper respiratory tract infections, mumps and other diseases. Due to their diverse active ingredients, it is believed that they may have excellent anti-inflammatory, antibacterial and antiviral effects. Therefore, we believe they may have multiple therapeutic targets for throat inflammation caused by bacterial or viral infections. This study utilizes network pharmacology methods to analyze the therapeutic effects of KBDKFY on Bacterial Pharyngeal Tonsillitis and Viral Pharyngitis, aiming to identify its active ingredients, action targets and related pathways through molecular docking. Additionally, it determines the afffnity between the main active ingredient and the core target before conducting in vitro bacteriostatic tests. The analysis results show that KBDKFY contains multiple active ingredients and potential targets for treating Bacterial Pharyngeal Tonsillitis and Viral Pharyngitis. KEGG enrichment analysis indicates that KBDKFY may have therapeutic effects on these conditions through pathways such as pathways in cancer, Kaposi sarcoma-associated herpesvirus infection, PI3K-Akt signaling pathway, and others. This provides a theoretical basis for further exploring pharmacological effects and clinical applications of KBDKFY.
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    Chemical composition and biological activity of Houttuynia cordata
    Yibo Wang, Yunpeng Yang, Xinyao Wang, Wenhan Wang, Luming Pan, Yu Chen
    Asian Journal of Traditional Medicines    2024, 19 (4): 223-234.  
    Abstract86)      PDF(pc) (6214KB)(73)       Save
    Houttuynia cordata is an important traditional Chinese medicine. It is widely used for clearing heat and detoxification, reducing  swelling and treating sores, diuresis and dehumidification. It is also used to treat lung carbuncles, ulcers, hemorrhoids,  rectal bleeding, spleen and stomach heat, which are caused by excess heat, heat toxicity, dampness, and disease heat. Modern  pharmacological experiments have shown that H. cordata has antibacterial, antiviral, immune enhancing, diuretic and other  effects. This article reviews the chemical components and biological activities of H. cordata to provide reference for clinical  application.
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    Analysis of wild medicinal vascular plant resources and diversity in Dabie Mountains, Anhui Province
    Qing Wang, Minli Ruan, Anhua Wang, Jingming Jia
    Asian Journal of Traditional Medicines    2024, 19 (4): 192-210.  
    Abstract72)      PDF(pc) (887KB)(81)       Save
    Dabie Mountains are located at the junction of Anhui, Henan and Hubei provinces in the East of China. With its varied altitude,  climate, and soil texture, Dabie Mountains are extremely rich in wild plant resources. The 12th Traditional Chinese Medicine  (TCM) Resources Scientific Expedition Team of Shenyang Pharmaceutical University conducted a study on wild vascular plants  resources, especially medicinal vascular plants, through field investigation, literature review and specimen identification. There  were 472 species of vascular plants belonging to 347 genera and 125 families collected during July 2018 in this area, of which 424  species were medicinal vascular plants, accounting for 89.83% of the total. From the perspective of medicinal parts, most of the  medicinal plants there have values in their roots and rhizomes, as well as the whole plants. The efficacy and characteristics of  these pharmaceutical dimensions were also summarized and analyzed in detail. Besides, among the wild vascular plants collected,  the most dominant families with the biggest numbers of species are Compositae, Lamiaceae, Liliaceae, Rosaceae, Leguminosae,  Ranunculaceae, Saxifragaceae and Polygonaceae, and the dominant genus are Viola and Sedum. In terms of life form, perennial  herbs are dominant, accounting for 55.72% of the total species, followed by some annual (or biennial) herbs, shrubs and lianas.  Finally, recommendations are put forward for strengthening the protection and utilization of wild medicinal plant resources in Dabie Mountains.
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    Quantitative analysis of Cefpodoxime Proxetil raw material and dry suspension using proton nuclear magnetic resonance
    Yufei Liu, Bin Li, Xinyu Tao, Dongyang Zhao, Xinyu Zhang, Yan Wu, Wenyi He, Chenggen Zhu, Xiangju Jin, Hongyue Liu, Xin Di, Ye Tian, Yanan Wang
    Asian Journal of Traditional Medicines    2024, 19 (6): 305-320.  
    Abstract69)      PDF(pc) (4367KB)(62)       Save
    This study established a simple, rapid, and accurate nuclear magnetic resonance (NMR) quantitative method to determine the cefpodoxime proxetil content in raw materials and dry suspensions, and evaluated the uncertainty. The relative content of cefpodoxime proxetil iso-A and iso-B was also analyzed based on 1 H NMR. In this study, an internal standard method was used, with DMSO-d 6 as the solvent and maleic acid and 1,3,5-trimethylbenzene as internal standards, to calculate the concentration of the samples. Quantitative analysis was performed using both the traditional quantitative NMR (traditional qNMR) and the quantitative Global Spectral Deconvolution (qGSD) method. The linearity range, quantitation limit, precision, robustness, and accuracy of these quantitative analysis methods were validated. The results indicated that both internal standards and integration methods met the requirements of the “9101 Guidelines for Analytical Method Validation” in the 2020 edition of the Chinese Pharmacopoeia. Compared to the traditional qNMR, qGSD has unique advantages in accurate quantitative analysis in complex systems. By using the combined HPLC-SPE-NMR technique, cefpodoxime proxetil iso-A and iso-B were enriched and analyzed, and their NMR data were accurately assigned. The quantitative analysis results were in line with the requirements of the Chinese Pharmacopoeia.
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    Analysis of vascular plant resources and diversity in Liupan Mountains of Ningxia Province, China
    Dongdong Wang, Minli Ruan, Jingming Jia, Anhua Wang
    Asian Journal of Traditional Medicines    2024, 19 (5): 266-274.  
    Abstract68)      PDF(pc) (371KB)(41)       Save
    Liupan Mountains are situated in the south of Ningxia Hui Autonomous Region and east of Gansu Province. This area is rich in  forests and vegetation. After field investigation, literature review and specimen identification, the plant resources and diversity  of Liupan Mountains were studied by the 4th Shenyang Pharmaceutical University Chinese Medicine Resources Scientific  Expedition Team. There were 161 species of vascular plants belonging to 60 families and 119 genera collected from July to August  2010 in this area. Among them, the dominant families are Campanulaceae, Ranunculaceae, Orobanchaceae, Asparagaceae,  Fabaceae, Rosaceae and Asteraceae, with 6, 7, 8, 8, 10, 10, and 22 species, respectively. Although representing only 11.7% of the  total number of families, these families had a species occupancy rate of over 44.1%. At the genus level, Pedicularis is the most  dominant genus with 6 species, while 92 genera contain only 1 species, accounting for 77.3% of the total number of genera. In a  word, our research has updated the plant resources and diversity in Liupan Mountains. Furthermore, by providing practical and  meaningful suggestions for strengthening the protection and utilization of plant resources in Liupan Mountains, our research is  of great significance for maintaining the diverse ecosystem in this area.
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    Network pharmacology to decipher the mechanism of Danggui  Longhui Wan against chronic myeloid leukemia
    Xuehan Ma, Qiulin Yan, Shaojiang Song, Guodong Yao
    Asian Journal of Traditional Medicines    2024, 19 (4): 177-191.  
    Abstract66)      PDF(pc) (92055KB)(32)       Save
    Chronic myeloid leukemia (CML) is a hematopoietic myeloproliferative disorder. The Chinese prescription Danggui Longhui  Wan (DGLHW) has been utilized in CML treatment, but its underlying mechanisms remain unclear. In this study, we gathered 794 constituents, 1249 drug targets, 1654 disease genes and 129 intersection genes. GO and KEGG were used to analyze the  function of these genes. Compatibility of prescription study showed that monarch drug, minister drug, assistant and guide drug  played a synergistic role in the treatment of CML. In addition, we obtained 20 hub genes and 12 key components. Molecular  docking indicated that the main compounds and core proteins had good binding ability. The results of this study also showed that  DGLHW might play a role in the treatment of CML by affecting MAPK, PI3K/AKT, FoxO and p53 signaling pathways.
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    Chemical compositions and pharmacological activities of Xanthium strumarium
    Ruoming Li, Yunpeng Yang, Xiaomeng Zhang, Yibo Wang, Wenhan Wang, Yao Zhao , Yu Chen
    Asian Journal of Traditional Medicines    2024, 19 (6): 342-352.  
    Abstract56)      PDF(pc) (3742KB)(111)       Save
    Xanthium strumarium (X. strumarium) is a traditional Chinese medicine with a long history. In recent years, with the development of modern pharmacology and chemical analysis technology, research on X. strumarium has been deepend. This paper aims to systematically summarize the chemical compositions and pharmacological effects of X. strumarium, in order to provide theoretical basis and reference for further exploration in its clinical application and drug development.
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    Chemical composition and pharmacological activities of the Phellodendron chinense Schneid
    Yi′an Shi, Yunpeng Yang, Wenhan Wang, Yibo Wang, Yao Zhao, Yu Chen
    Asian Journal of Traditional Medicines    2024, 19 (5): 285-298.  
    Abstract55)      PDF(pc) (2443KB)(29)       Save
    Phellodendron chinense Schneid (P. chinense), as a traditional Chinese medicine, is commonly used in clinical practice. It has the  effects of drying dampness, clearing heat, detoxifying, purging fire, and reducing swelling. Its main chemical components are  flavonoids and alkaloids, which have various pharmacological effects such as lowering blood sugar, lowering blood pressure and  immunosuppression. With the continuous development of modern science and technology, the research on P. chinense Schneid  has increased. This study reviews the chemical components and pharmacological effects of P. chinense Schneid, and provides  reference for its further research and development.
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    Analysis of plant resources and diversity in some areas of Inner Mongolia, China
    Terigen Bao, Minli, Jingming Jia , Anhua Wang
    Asian Journal of Traditional Medicines    2024, 19 (6): 321-333.  
    Abstract53)      PDF(pc) (390KB)(67)       Save
    Inner Mongolia Autonomous Region is located in the north of China. The vast area and complex terrain of this region make it rich in plant resources. The 11th Shenyang Pharmaceutical University Chinese Medicine Resources Scientific Expedition Team investigated the plant resources and diversity in some areas of Inner Mongolia through field investigation, literature review and specimen identification. From July to August, 2017, 215 species of vascular plants belonging to 59 families and 160 genera were collected. The dominant families are RanunculaceaeLamiaceaeRosaceaeFabaceae and Asteraceae, with 11, 12, 15, 19, and 37 species, respectively. There are 55 families, 132 genera and 163 species of medical plant recources in some areas of Inner Mongolia. 27 vascular plants are Mongolian Medicine. In a word, our research has updated the plant recources and diversity in all areas of Inner Mongolia. Furthermore, this study provides practical and meaningful suggestions for strengthening the protection and utilization of plant resources in some areas of Inner Mongolia, which is of great significance for maintaining local plant diversity.
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    Chemical composition and biological activities of Lysimachia capillipes Hemsl
    Ran Guo, Ruoming Li, Xiaomeng Zhang, Wenhan Wang, Yao Zhao, Yu Chen
    Asian Journal of Traditional Medicines    2025, 20 (1): 14-29.  
    Abstract53)      PDF(pc) (5618KB)(96)       Save
    Lysimachia capillipes (L. capillipes) Hemsl, belong to primulaceae pearl vegetables genus, is a treasure in traditional Chinese medicine. It has the effects of invigorating qi and tonifying deffciency, dispelling wind and activating blood, awakening the brain, relieving cough and regulating menstruation. With the development of modern medicine, the active components and therapeutic mechanisms of L. capillipes Hemsl have been gradually revealed. The present report systematically reviews the chemical composition and biological activities of L. capillipes Hemsl, to provide scientiffc basis and reference for detailed research on L. capillipes Hemsl.
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    Research progress of different kinds of traditional Chinese medicine in the treatment of type 2 diabetes
    Yuzheng Xiang, Xiaomeng Zhang, Ruoming Li, Wenhan Wang, Yao Zhao, Yu Chen
    Asian Journal of Traditional Medicines    2025, 20 (1): 30-42.  
    Abstract50)      PDF(pc) (17418KB)(34)       Save
    type 2 diabetes; traditional Chinese medicine; research progress
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    Review on Croton crassifolius: From botanical characteristics to biotransformation and better utilization
    Guoyu Wang, Wenhan Wang, Xiaomeng Zhang, Yunpeng Yang, Yibo Wang, Yao Zhao , Yu Chen
    Asian Journal of Traditional Medicines    2024, 19 (6): 334-341.  
    Abstract41)      PDF(pc) (6252KB)(117)       Save
    Croton crassifolius (C. crassifolius) is a kind of traditional Chinese medicine, with a history hundreds of years in China. By consulting Sciencedirect databases and Web of Science databases, 68 related articles were found, 12 of which were related to chemical composition and pharmacological activity. It was used by the ancients as the medicine to treat stomach trouble, rheumatism, poliomyelitis and injuries, and it is the treasure of traditional Chinese medicine in China. With the development of  modern medicine, the active ingredients and therapeutic mechanism of C. crassifolius have been gradually revealed. In this study, the functions and applications of C. crassifolius were reviewed from the aspects of botany, traditional Chinese medicine therapy and biotransformation of substances, so as to better understand and use C. crassifolius and provide more effective drug choices for clinical treatment.
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    Research progress on chemical components, pharmacological effects, and quality control of Crotalaria ferruginea Graham ex Benth.
    Shuxing Tian, Lan Zou, Yue Yang, Qiaoyan Yang, Fayun Zi, Pan Zhang
    Asian Journal of Traditional Medicines    2025, 20 (2): 77-89.  
    Abstract34)      PDF(pc) (2016KB)(14)       Save
    Crotalaria ferruginea Graham ex Benth. is a commonly used herb among ethnic minorities. Its whole plant is used as medicine  for conditions such as heatstroke, tinnitus, hearing loss, phlegm heat cough, gum swelling and pain, lower back and knee pain,  vaginal discharge and infantile malnutrition. Modern pharmaceutical research has found that Crotalaria ferruginea Graham ex  Benth. mainly contains flavonoids, steroids, organic acids and terpenes, which have antibacterial, free radical scavenging, anti-inflammatory and other effects. Quality control mainly focuses on characteristics, identification, content determination, etc. This article summarizes the recent research progress on the chemical composition, pharmacological effects, quality control and extraction process of Crotalaria ferruginea Graham ex Benth. on the basis of existing Crotalaria ferruginea Graham ex Benth.  research reports.
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    Research progress on chemical constituents and pharmacological effects of medicinal plant Scutellaria baicalensis
    Yunpeng Yang, Ruiqi Ma, Yuzheng Xiang, Yu Wang, Rui Liu, Ying Li, Yu Chen
    Asian Journal of Traditional Medicines    2025, 20 (2): 65-76.  
    Abstract16)      PDF(pc) (5376KB)(15)       Save
    Scutellaria baicalensis (S. baicalensis) is a heat-clearing and moisture-drying medicine, which is used to treat diseases such as  warm fever, upper respiratory tract infection, lung heat cough, moist heat jaundice, pneumonia, dysentery, hemoptysis, red  eyes, restless fetus, hypertension, abscess, swelling and boils. In recent years, with the in-depth study of its chemical composition  and pharmacological activity, it was found that the clinical antibacterial activity of S. baicalensis was significant, and it did not produce drug resistance. The chemical constituents and pharmacological effects of S. baicalensis were reviewed in this paper. This review can provide reference for further development and utilization of medicinal value of S. baicalensis.
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    Application of microbiocontrol technology in the cultivation of traditional Chinese medicine
    Jiankun Jin, Rui Liu, Ruiqi Ma, Yuzheng Xiang, Yibo Wang, Meng Zhang, Yu Chen
    Asian Journal of Traditional Medicines    2025, 20 (2): 90-98.  
    Abstract15)      PDF(pc) (7396KB)(18)       Save
    Plant diseases affect the cultivation of Chinese herbal medicines, while traditional chemical pesticides have many drawbacks such  as environmental pollution, health risks and disruption of ecological balance. Microbiocontrol has gradually appeared in public  view, and its application has become increasingly extensive. This paper reviews the disease-causing species of medicinal plants,  including fungal, bacterial, nematode, viral and parasitic pests, and reviews the diseases caused by microorganisms in traditional  Chinese medicine planting and their biological control by consulting Sciencedirect databases and Web of Science databases.  4667 related articles were found, of which 552 were related to microbiocontrol technology and cultivation of traditional Chinese  medicines. This review provides a reference for the green planting technology of traditional Chinese medicine.
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    Discovery of quality marker and study on its pharmacodynamic differences in antirheumatoid arthritis in the three original plants of Clematidis Radix et Rhizoma
    Liqi Cao, Tingting Chen, Chen Liu, Yueru Li, Xiaoqiu Liu, Xiajing Xu, Yingni Pan
    Asian Journal of Traditional Medicines    2025, 20 (2): 49-64.  
    Abstract14)      PDF(pc) (5681KB)(18)       Save
    Ultra-performance liquid chromatography-mass spectrometry (UPLC-MS) technology was employed to analyze the chemical composition of three Clematidis Radix et Rhizoma sourced from different origins. Common characteristic components were identified through comprehensive literature review and the integration of fragment ion data. A rheumatoid arthritis (AA) model was induced in Sprague-Dawley (SD) rats using Freund’s complete adjuvant, and simultaneous administration of extracts from the three original plants of Clematidis Radix et Rhizoma, along with different doses of magnoflorine, was conducted to evaluate differences in therapeutic efficacy. A common characteristic component was identified, magnoflorine, present in Clematis chinensis Osbeck. Clematis hexapetala Pall., and Clematis manshurica Rupr. Extracts from all three original plants, as well as each dose group of the Rhizomas of Clematis chinensis Osbeck. Clematis hexapetala Pall., Clematis manshurica Rupr., and magnoflorine, demonstrated efficacy in alleviating rheumatoid arthritis symptoms by enhancing cellular infiltration, reducing vascular opacification, and lowering serum levels of inflammatory factors. Magnoflorine has the potential to be used as a quality marker for the three original plants of Clematidis Radix et Rhizoma. Additionally, both the three original plants and magnoflorine exhibit therapeutic potential for rheumatoid arthritis, which provides a solid theoretical and experimental basis for the establishment of more scientifically grounded quality standards of Clematidis Radix et Rhizoma and promotes the rational utilization of medicinal resources.
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    A review: Research progress on multi-target neuroprotective effects of n-butylphthalide  extracted from Apium graveolens seeds
    Jiahui Huo, Jingxian Ren, Xiaoxiao Huang, Xiaoliang Wang
    Asian Journal of Traditional Medicines    2024, 19 (5): 275-284.  
    Abstract0)      PDF(pc) (5286KB)(0)       Save
    Apium graveolens, an annual herb belonging to the family of Apiaceae, is widely distributed in North and South America,  Southern Europe, Africa and Asia. Apium graveolens seeds have a rich history in traditional Chinese medicine for treating  hypertension, headaches, vertigo and epilepsy. N-butylphthalide, originally extracted from Apium graveolens seeds, represents  a first-in-class drug developed independently in China. Its broad pharmacological activities on nervous system disorders have  garnered significant attention from researchers globally. This review focuses on the pharmacological research of n-butylphthalide  on central nervous system diseases, including ischemic stroke, Alzheimer’s disease, Parkinson’s disease and amyotrophic lateral  sclerosis. The purpose is to pave the way for future study on the mechanistic targets of n-butylphthalide.
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