Exploring the molecular mechanism of Corydalis yanhusuo against prostate cancer based on network pharmacology and molecular docking validation

Abstract

Abstract:

The molecular mechanism underlying Corydalis Yanhusuo’s therapeutic potential in prostate cancer (PCa) treatment was elucidated using network pharmacology and molecular docking. Nineteen active ingredients, 399 drug targets, 1790 disease targets and 143 intersection targets were identified. Ten core targets were screened from the protein-protein interaction network. Enrichment analysis revealed 133 GO terms and 114 KEGG pathways. Corydalis Yanhusuo may potentially treat prostate cancer through pathways such as the Rap1 signaling pathway, phospholipase D signaling pathway, Ras signaling pathway, VEGF signaling pathway and JAK-STAT signaling pathway. Significant differences in expression were observed for EGFR, PDGFRA, PIK3CA, PIK3CD, PIK3CG and PIK3R1. Molecular docking and dynamics simulation analysis showed low binding energy between active components and the six core genes of Corydalis Yanhusuo, indicating a favorable docking effect. This study shows that Corydalis Yanhusuo exhibits promise in prostate cancer treatment through a synergistic “multi-component-multi-targetmulti-pathway” effect.

Key words: color:#231F20, font-style:italic, ">Corydalis Yanhusuo, prostate cancer, network pharmacology, molecular mechanism, molecular docking

Ying Zhu#, Junwei Lu#, Jumin Xie.

Exploring the molecular mechanism of Corydalis yanhusuo against prostate cancer based on network pharmacology and molecular docking validation

[J]. Asian Journal of Traditional Medicines, 2024, 19(5): 241-265.

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