A review: Research progress on multi-target neuroprotective effects of n-butylphthalide  extracted from Apium graveolens seeds #br#

Abstract

Abstract:

Apium graveolens, an annual herb belonging to the family of Apiaceae, is widely distributed in North and South America, Southern Europe, Africa and Asia. Apium graveolens seeds have a rich history in traditional Chinese medicine for treating hypertension, headaches, vertigo and epilepsy. N-butylphthalide, originally extracted from Apium graveolens seeds, represents a first-in-class drug developed independently in China. Its broad pharmacological activities on nervous system disorders have garnered significant attention from researchers globally. This review focuses on the pharmacological research of n-butylphthalide on central nervous system diseases, including ischemic stroke, Alzheimer’s disease, Parkinson’s disease and amyotrophic lateral sclerosis. The purpose is to pave the way for future study on the mechanistic targets of n-butylphthalide.

Key words: font-family:微软雅黑, Microsoft YaHei, ">color:#231F20, font-style:italic, ">Apium graveolens color:#231F20, ">seeds, color:#231F20, font-style:italic, ">ncolor:#231F20, ">-butylphthalide, central nervous system diseases

Jiahui Huo, Jingxian Ren, Xiaoxiao Huang, Xiaoliang Wang. A review: Research progress on multi-target neuroprotective effects of n-butylphthalide extracted from Apium graveolens seeds [J]. Asian Journal of Traditional Medicines, 2024, 19(5): 275-284.

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