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    Phytochemical investigation of the branches of Viburnum awabuki K. Koch and its chemotaxonomic significance
    Sidie Li†, Ningning Du†, Qi Song, Xiaoxiao Huang, Shaojiang Song
    Asian Journal of Traditional Medicines    2025, 20 (5): 213-225.  
    Abstract44)      PDF(pc) (2390KB)(87)       Save
    Phytochemical investigation of the branches of Viburnum awabuki K. Koch led to the isolation of thirteen known compounds, including five lignans (1-5), one phytosterol (6), two phenylpropanoids (7-8), one chromone derivative (9), three pentacyclic triterpenoids (10-12), and one glyceride (13). The structures of these compounds were elucidated through extensive spectroscopic analyses and comparison of experimental data with literature data. Additionally, the chemotaxonomic significance of the isolated secondary metabolites was also discussed.
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    Research progress on hepatotoxicity and toxicity reduction of Toosendan Fructus
    Xiaoyu Jiang, Yiduo Zhu, Mengwen Shang, Jun Yin, Zhihui Liu
    Asian Journal of Traditional Medicines    2025, 20 (5): 226-237.  
    Abstract21)      PDF(pc) (2302KB)(242)       Save
    This study reviews the hepatotoxic chemicals, mechanisms of toxicity, and detoxification methods of Toosendan Fructus (TF). Limonin-type triterpenoids, as primary hepatotoxic components, mediate toxicity though inflammation, oxidative stress, mitochondrial dysfunction, ferroptosis, and apoptosis. Hepatotoxicity can be mitigated by controlling dosage, using processed forms of the herbs, and through rational herbal compatibility. The review provides insights for enhancing the safety and clinical application of TF.
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    Applications of capillary electrophoresis in traditional Chinese medicine
    Xinyi Zhang, Jiankun Jin, Zixuan Che, Rui Liu, Ying Li, Meng Zhang, Yu Chen
    Asian Journal of Traditional Medicines    2025, 20 (5): 238-247.  
    Abstract29)      PDF(pc) (812KB)(31)       Save
    Capillary electrophoresis (CE), recognized for its minimal reagent dosage, rapid analysis, and high efficiency, holds significant promise for the analysis of traditional Chinese medicines (TCM). This article reviews the application of CE in the determination of active ingredients in TCM. The active substances of herbal medicines have been classified and discussed based on their chemical properties, and the CE methods applied to different substances are summarized and discussed. This article also provides some suggestions for future research and improvement.
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    Mechanisms and preliminary validation of luteolin in the treatment of hyperuricemia based on network pharmacology and toxicology studies
    Yulin Hong† , Xinhui Yang† , Zhenyu Liu, Yizhen Chen, Yunkun Zhang, Xin Wu
    Asian Journal of Traditional Medicines    2025, 20 (4): 161-172.  
    Abstract108)      PDF(pc) (2310KB)(89)       Save
    Hyperuricemia (HUA) refers to a condition where fasting serum uric acid levels exceed 420 μmol/L in men and 350 μmol/L in women, affecting 17.4% of China’s general population, showing increasing prevalence among younger individuals. Luteolin, a common flavonoid compound, exhibits multiple biological effects, including inhibition of tumor proliferation and inflammatory responses. It also suppresses the activity of urate transporter 1 (URAT1), promoting uric acid excretion. This study is the first to integrate network toxicology and network pharmacology approaches to systematically analyze the multi-target mechanisms of adenine-induced HUA and luteolin-treated HUA, with molecular docking validation of interaction targets. We constructed compound-pathway-intersection gene networks and a dual-group PPI network to analyze the mechanisms of adenine-induced HUA and luteolin-treated HUA. The dual-group PPI network identified 7 shared targets, namely XDH, PYGL, IL10, PPARG, TNF, VEGFA, and MAOA, involving core intersecting pathways such as purine-xanthine metabolism and insulin resistance. Luteolin may activate PPARG to regulate inflammation and uric acid excretion modules in the adenine network. GO-KEGG analysis indicates that intersection genes for adenine pathogenesis involve diverse biological processes, cellular components, and molecular functions, with core target KEGG analysis revealing 15 signaling pathways. Luteolin’s therapeutic targets are associated with more entries, and its core target KEGG analysis identified 46 signaling pathways. Molecular docking shows TNF, PPARG, and PYGL bind to both luteolin and adenine with negative binding energies, and luteolin’s binding energies are all below 5 kJ/mol, confirming stable binding. Luteolin’s anti-HUA mechanism is characterized by inhibition of production, promotion of excretion, anti-inflammation and metabolic regulation, but interactions with gut microbiota metabolites require further study.
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    Application of molecular identification techniquesin traditional Chinese medicine
    Jiankun Jin, Weiwei Zhang, Rui Liu, Ruiqi Ma, Yuzheng Xiang, Yibo Wang, Ying Li, Yu Chen
    Asian Journal of Traditional Medicines    2025, 20 (4): 173-180.  
    Abstract80)      PDF(pc) (1703KB)(64)       Save
    In recent years, molecular identification technology has become the predominant approach for the identification of traditional Chinese medicine. The molecular identification techniques in recent years were analyzed and summarized in this paper, such as RAPD, ISSR, RFLP, AFLP, SNP, and DNA bar code sequence analysis techniques. By consulting Sciencedirect databases and Web of Science databases, 2348 related articles were found, of which 39 were related to molecular identification techniques and traditional Chinese medicine. The application of the molecular identification techniques in four aspects was reviewed, namely the identification on the authenticity (true or false), multi-source identification and genetic diversity, producing area, and growing year discrimination of traditional Chinese medicine.
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    Analysis and insights into the changes of traditional Chinese medicine review and approval from 2020 to 2024
    Wenli Li, Qian Sun, Wenxia Ding
    Asian Journal of Traditional Medicines    2025, 20 (4): 181-194.  
    Abstract85)      PDF(pc) (1354KB)(1922)       Save
    The official release of the “Drug Registration Management Measures” in January 2020 marked a new milestone in the  classification management of traditional Chinese medicine (TCM) registration, ushering in a new era for the registration and  application of innovative TCM drugs. This article provides a detailed analysis of the approval status of innovative TCM drugs,  improved new drugs, and ancient classic prescription compound preparations from 2020 to 2024, revealing the significant  achievements made in the inheritance and innovation of TCM in China. The study found that the number of New Drug  Applications (NDAs) and Investigational New Drug Applications (INDs) have increased annually, with a particularly notable  surge in the submission of applications for classic prescription compound preparations. The approval rates for innovative  TCM drugs and improved new drugs have significantly increased, along with the streamlining of review and approval process,  leading to shorter development cycles and reduced costs. Key findings include: (1) Enterprises demonstrate strong enthusiasm  for the research and development of innovative and improved TCM drugs, actively engaging in various types of drug R&D and  submissions; (2) Classic prescription compound preparations have become a focal point for enterprises due to their shorter  development cycles and lower costs; (3) Improvement to the “three-combined” evidence system has accelerated the R&D process  by incorporating real-world data. Through this study, we aim to provide valuable insights for TCM R&D enterprises and  policymakers, promoting the sustained prosperity and development of the TCM sector.
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    Research progress of chemical composition and pharmacological  activity of Boenninghausenia sessilicarpa Lévl.
    Shuxing Tian, Lan Zou, Yue Yang, Qiaoyan Yang, Fayun Zi, Pan Zhang
    Asian Journal of Traditional Medicines    2025, 20 (4): 195-207.  
    Abstract58)      PDF(pc) (3167KB)(38)       Save
    Boenninghausenia sessilicarpa Lévl. is a commonly used folk medicine in southwest Yunnan. It has the effects of clearing heat  and detoxifying, promoting qi circulation and activating blood circulation. It is used to treat various conditions such as colds,  tonsillitis, mumps, lung-heat induced cough and asthma, abdominal distension and pain, pyelonephritis, gangrene of the  extremities, low back pain, and bruises from falls and injuries. This paper summarizes recent research progress on the chemical  constituents and pharmacological activities of Boenninghausenia sessilicarpa Lévl., aiming to advance fundamental and clinical  studies on this plant and provide a reference for enhanced medical utilization.
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    Applications of metabonomics in traditional Chinese medicine
    Ruiqi Ma, Rui Liu, Yuzheng Xiang, Yibo Wang, Ran Guo, Ying Li, Yu Chen
    Asian Journal of Traditional Medicines    2025, 20 (3): 121-129.  
    Abstract84)      PDF(pc) (881KB)(65)       Save
    Metabonomics, a key aspect of systems biology, offers novel approaches for early diagnosis, pharmacotherapy, and health management in Traditional Chinese Medicine (TCM). This paper summarizes its applications in establishing TCM quality standards, exploring material basis, clarifying mechanism, and assessing toxicity. By profiling TCM and its metabolites, metabonomics comprehensively captures chemical traits, enhancing quality evaluation precision. It also tracks metabolic  dynamics to understand TCM’s absorption, distribution, metabolism, excretion, thereby facilitating the identification of active components and their underlying mechanisms. In toxicity assessment, metabonomics uncovers hepatic and renal toxicity while  elucidating potential mechanisms. In summary, metabonomics fosters TCM modernization and globalization, serving as a pivotal tool for advancing research and development. 
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    Evolution of the protection system for traditional Chinese  medicine varieties and the strategic responses of traditional  Chinese medicine enterprises
    Wenli Li, Qian Sun, Xiang Li, Zhaojun Meng, Mengmeng Li, Wenxia Ding, Pengfei Zhang
    Asian Journal of Traditional Medicines    2025, 20 (3): 130-139.  
    Abstract44)      PDF(pc) (841KB)(860)       Save
    The protection system for traditional Chinese medicine (TCM) varieties, as an important policy tool to promote the development  of TCM, has a long history of over 30 years, from the promulgation of the “Regulations on the Protection of Traditional Chinese  Medicine Varieties” in 1992 to the comprehensive revision of the draft for soliciting opinions in 2022. The TCM protection system  evolves to meet the needs of innovative development of TCM. This paper reviews the policy developments in TCM varieties  protection, collates protection data (1993 to 2024), and analyzes enterprises application strategies amid impending regulatory  changes. 
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    From natural medicines to metal weapons: therapeutic potential of flavonoid  metabolites in regulating host-Mycobacterium tuberculosis metal interactions
    Tianyi Zhao, Qingxuan Wu, Yihao Fan, Ru Li, Zifei Yang, Wenxin Li, Xiaoyun Zhao
    Asian Journal of Traditional Medicines    2025, 20 (3): 140-155.  
    Abstract73)      PDF(pc) (9726KB)(211)       Save
    Tuberculosis, an infectious disease, causes considerable morbidity and mortality. Within the host immune system, transition  metals play vital roles in combating Mycobacterium tuberculosis (MTB), acting as catalytic cofactors, mediating electron  transport, and catalyzing antimicrobial radical formation. Both the host and MTB have developed mechanisms to maintain  metal homeostasis. Flavonoids, important herbal materials with potent iron-chelating ability, have gained attention for their  antitubercular and anti-inflammatory effects, making them a promising treatment option. This review explores how trace  metals restrict MTB and the dynamic balance between pathogen and host, revealing innovative perspectives for therapeutic  interventions. 
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    Discovery of quality marker and study on its pharmacodynamic differences in antirheumatoid arthritis in the three original plants of Clematidis Radix et Rhizoma
    Liqi Cao, Tingting Chen, Chen Liu, Yueru Li, Xiaoqiu Liu, Xiajing Xu, Yingni Pan
    Asian Journal of Traditional Medicines    2025, 20 (2): 49-64.  
    Abstract77)      PDF(pc) (5681KB)(321)       Save
    Ultra-performance liquid chromatography-mass spectrometry (UPLC-MS) technology was employed to analyze the chemical composition of three Clematidis Radix et Rhizoma sourced from different origins. Common characteristic components were identified through comprehensive literature review and the integration of fragment ion data. A rheumatoid arthritis (AA) model was induced in Sprague-Dawley (SD) rats using Freund’s complete adjuvant, and simultaneous administration of extracts from the three original plants of Clematidis Radix et Rhizoma, along with different doses of magnoflorine, was conducted to evaluate differences in therapeutic efficacy. A common characteristic component was identified, magnoflorine, present in Clematis chinensis Osbeck. Clematis hexapetala Pall., and Clematis manshurica Rupr. Extracts from all three original plants, as well as each dose group of the Rhizomas of Clematis chinensis Osbeck. Clematis hexapetala Pall., Clematis manshurica Rupr., and magnoflorine, demonstrated efficacy in alleviating rheumatoid arthritis symptoms by enhancing cellular infiltration, reducing vascular opacification, and lowering serum levels of inflammatory factors. Magnoflorine has the potential to be used as a quality marker for the three original plants of Clematidis Radix et Rhizoma. Additionally, both the three original plants and magnoflorine exhibit therapeutic potential for rheumatoid arthritis, which provides a solid theoretical and experimental basis for the establishment of more scientifically grounded quality standards of Clematidis Radix et Rhizoma and promotes the rational utilization of medicinal resources.
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    Research progress on chemical constituents and pharmacological effects of medicinal plant Scutellaria baicalensis
    Yunpeng Yang, Ruiqi Ma, Yuzheng Xiang, Yu Wang, Rui Liu, Ying Li, Yu Chen
    Asian Journal of Traditional Medicines    2025, 20 (2): 65-76.  
    Abstract97)      PDF(pc) (5376KB)(423)       Save
    Scutellaria baicalensis (S. baicalensis) is a heat-clearing and moisture-drying medicine, which is used to treat diseases such as  warm fever, upper respiratory tract infection, lung heat cough, moist heat jaundice, pneumonia, dysentery, hemoptysis, red  eyes, restless fetus, hypertension, abscess, swelling and boils. In recent years, with the in-depth study of its chemical composition  and pharmacological activity, it was found that the clinical antibacterial activity of S. baicalensis was significant, and it did not produce drug resistance. The chemical constituents and pharmacological effects of S. baicalensis were reviewed in this paper. This review can provide reference for further development and utilization of medicinal value of S. baicalensis.
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    Research progress on chemical components, pharmacological effects, and quality control of Crotalaria ferruginea Graham ex Benth.
    Shuxing Tian, Lan Zou, Yue Yang, Qiaoyan Yang, Fayun Zi, Pan Zhang
    Asian Journal of Traditional Medicines    2025, 20 (2): 77-89.  
    Abstract108)      PDF(pc) (2016KB)(84)       Save
    Crotalaria ferruginea Graham ex Benth. is a commonly used herb among ethnic minorities. Its whole plant is used as medicine  for conditions such as heatstroke, tinnitus, hearing loss, phlegm heat cough, gum swelling and pain, lower back and knee pain,  vaginal discharge and infantile malnutrition. Modern pharmaceutical research has found that Crotalaria ferruginea Graham ex  Benth. mainly contains flavonoids, steroids, organic acids and terpenes, which have antibacterial, free radical scavenging, anti-inflammatory and other effects. Quality control mainly focuses on characteristics, identification, content determination, etc. This article summarizes the recent research progress on the chemical composition, pharmacological effects, quality control and extraction process of Crotalaria ferruginea Graham ex Benth. on the basis of existing Crotalaria ferruginea Graham ex Benth.  research reports.
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    Application of microbiocontrol technology in the cultivation of traditional Chinese medicine
    Jiankun Jin, Rui Liu, Ruiqi Ma, Yuzheng Xiang, Yibo Wang, Meng Zhang, Yu Chen
    Asian Journal of Traditional Medicines    2025, 20 (2): 90-98.  
    Abstract89)      PDF(pc) (7396KB)(240)       Save
    Plant diseases affect the cultivation of Chinese herbal medicines, while traditional chemical pesticides have many drawbacks such  as environmental pollution, health risks and disruption of ecological balance. Microbiocontrol has gradually appeared in public  view, and its application has become increasingly extensive. This paper reviews the disease-causing species of medicinal plants,  including fungal, bacterial, nematode, viral and parasitic pests, and reviews the diseases caused by microorganisms in traditional  Chinese medicine planting and their biological control by consulting Sciencedirect databases and Web of Science databases.  4667 related articles were found, of which 552 were related to microbiocontrol technology and cultivation of traditional Chinese  medicines. This review provides a reference for the green planting technology of traditional Chinese medicine.
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    The mechanism analysis of KangBingDuKouFuYe in treating throat infection based on network pharmacology and molecular docking
    Ying Long# , Xinhui Yang# , Hongfei Lv, Zhenyu Liu, Tianjun Guo, Chaohui Yang, Hui Liu, Qijia Yang, Xin Wu
    Asian Journal of Traditional Medicines    2025, 20 (1): 1-13.  
    Abstract153)      PDF(pc) (14358KB)(527)       Save
    KangBingDuKouFuYe (KBDKFY) is widely used to treat inffuenza, upper respiratory tract infections, mumps and other diseases. Due to their diverse active ingredients, it is believed that they may have excellent anti-inflammatory, antibacterial and antiviral effects. Therefore, we believe they may have multiple therapeutic targets for throat inflammation caused by bacterial or viral infections. This study utilizes network pharmacology methods to analyze the therapeutic effects of KBDKFY on Bacterial Pharyngeal Tonsillitis and Viral Pharyngitis, aiming to identify its active ingredients, action targets and related pathways through molecular docking. Additionally, it determines the afffnity between the main active ingredient and the core target before conducting in vitro bacteriostatic tests. The analysis results show that KBDKFY contains multiple active ingredients and potential targets for treating Bacterial Pharyngeal Tonsillitis and Viral Pharyngitis. KEGG enrichment analysis indicates that KBDKFY may have therapeutic effects on these conditions through pathways such as pathways in cancer, Kaposi sarcoma-associated herpesvirus infection, PI3K-Akt signaling pathway, and others. This provides a theoretical basis for further exploring pharmacological effects and clinical applications of KBDKFY.
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    Chemical composition and biological activities of Lysimachia capillipes Hemsl
    Ran Guo, Ruoming Li, Xiaomeng Zhang, Wenhan Wang, Yao Zhao, Yu Chen
    Asian Journal of Traditional Medicines    2025, 20 (1): 14-29.  
    Abstract122)      PDF(pc) (5618KB)(423)       Save
    Lysimachia capillipes (L. capillipes) Hemsl, belong to primulaceae pearl vegetables genus, is a treasure in traditional Chinese medicine. It has the effects of invigorating qi and tonifying deffciency, dispelling wind and activating blood, awakening the brain, relieving cough and regulating menstruation. With the development of modern medicine, the active components and therapeutic mechanisms of L. capillipes Hemsl have been gradually revealed. The present report systematically reviews the chemical composition and biological activities of L. capillipes Hemsl, to provide scientiffc basis and reference for detailed research on L. capillipes Hemsl.
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    Research progress of different kinds of traditional Chinese medicine in the treatment of type 2 diabetes
    Yuzheng Xiang, Xiaomeng Zhang, Ruoming Li, Wenhan Wang, Yao Zhao, Yu Chen
    Asian Journal of Traditional Medicines    2025, 20 (1): 30-42.  
    Abstract116)      PDF(pc) (17418KB)(1589)       Save
    type 2 diabetes; traditional Chinese medicine; research progress
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    Analysis of plant resources and diversity in some areas of Inner Mongolia, China
    Terigen Bao, Minli, Jingming Jia , Anhua Wang
    Asian Journal of Traditional Medicines    2024, 19 (6): 321-333.  
    Abstract117)      PDF(pc) (390KB)(441)       Save
    Inner Mongolia Autonomous Region is located in the north of China. The vast area and complex terrain of this region make it rich in plant resources. The 11th Shenyang Pharmaceutical University Chinese Medicine Resources Scientific Expedition Team investigated the plant resources and diversity in some areas of Inner Mongolia through field investigation, literature review and specimen identification. From July to August, 2017, 215 species of vascular plants belonging to 59 families and 160 genera were collected. The dominant families are RanunculaceaeLamiaceaeRosaceaeFabaceae and Asteraceae, with 11, 12, 15, 19, and 37 species, respectively. There are 55 families, 132 genera and 163 species of medical plant recources in some areas of Inner Mongolia. 27 vascular plants are Mongolian Medicine. In a word, our research has updated the plant recources and diversity in all areas of Inner Mongolia. Furthermore, this study provides practical and meaningful suggestions for strengthening the protection and utilization of plant resources in some areas of Inner Mongolia, which is of great significance for maintaining local plant diversity.
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    Review on Croton crassifolius: From botanical characteristics to biotransformation and better utilization
    Guoyu Wang, Wenhan Wang, Xiaomeng Zhang, Yunpeng Yang, Yibo Wang, Yao Zhao , Yu Chen
    Asian Journal of Traditional Medicines    2024, 19 (6): 334-341.  
    Abstract107)      PDF(pc) (6252KB)(421)       Save
    Croton crassifolius (C. crassifolius) is a kind of traditional Chinese medicine, with a history hundreds of years in China. By consulting Sciencedirect databases and Web of Science databases, 68 related articles were found, 12 of which were related to chemical composition and pharmacological activity. It was used by the ancients as the medicine to treat stomach trouble, rheumatism, poliomyelitis and injuries, and it is the treasure of traditional Chinese medicine in China. With the development of  modern medicine, the active ingredients and therapeutic mechanism of C. crassifolius have been gradually revealed. In this study, the functions and applications of C. crassifolius were reviewed from the aspects of botany, traditional Chinese medicine therapy and biotransformation of substances, so as to better understand and use C. crassifolius and provide more effective drug choices for clinical treatment.
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    Chemical compositions and pharmacological activities of Xanthium strumarium
    Ruoming Li, Yunpeng Yang, Xiaomeng Zhang, Yibo Wang, Wenhan Wang, Yao Zhao , Yu Chen
    Asian Journal of Traditional Medicines    2024, 19 (6): 342-352.  
    Abstract118)      PDF(pc) (3742KB)(1811)       Save
    Xanthium strumarium (X. strumarium) is a traditional Chinese medicine with a long history. In recent years, with the development of modern pharmacology and chemical analysis technology, research on X. strumarium has been deepend. This paper aims to systematically summarize the chemical compositions and pharmacological effects of X. strumarium, in order to provide theoretical basis and reference for further exploration in its clinical application and drug development.
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    Quantitative analysis of Cefpodoxime Proxetil raw material and dry suspension using proton nuclear magnetic resonance
    Yufei Liu, Bin Li, Xinyu Tao, Dongyang Zhao, Xinyu Zhang, Yan Wu, Wenyi He, Chenggen Zhu, Xiangju Jin, Hongyue Liu, Xin Di, Ye Tian, Yanan Wang
    Asian Journal of Traditional Medicines    2024, 19 (6): 305-320.  
    Abstract154)      PDF(pc) (4367KB)(133)       Save
    This study established a simple, rapid, and accurate nuclear magnetic resonance (NMR) quantitative method to determine the cefpodoxime proxetil content in raw materials and dry suspensions, and evaluated the uncertainty. The relative content of cefpodoxime proxetil iso-A and iso-B was also analyzed based on 1 H NMR. In this study, an internal standard method was used, with DMSO-d 6 as the solvent and maleic acid and 1,3,5-trimethylbenzene as internal standards, to calculate the concentration of the samples. Quantitative analysis was performed using both the traditional quantitative NMR (traditional qNMR) and the quantitative Global Spectral Deconvolution (qGSD) method. The linearity range, quantitation limit, precision, robustness, and accuracy of these quantitative analysis methods were validated. The results indicated that both internal standards and integration methods met the requirements of the “9101 Guidelines for Analytical Method Validation” in the 2020 edition of the Chinese Pharmacopoeia. Compared to the traditional qNMR, qGSD has unique advantages in accurate quantitative analysis in complex systems. By using the combined HPLC-SPE-NMR technique, cefpodoxime proxetil iso-A and iso-B were enriched and analyzed, and their NMR data were accurately assigned. The quantitative analysis results were in line with the requirements of the Chinese Pharmacopoeia.
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    Exploring the molecular mechanism of Corydalis yanhusuo against prostate cancer based on network pharmacology and molecular docking validation
    Ying Zhu#, Junwei Lu#, Jumin Xie
    Asian Journal of Traditional Medicines    2024, 19 (5): 241-265.  
    Abstract134)      PDF(pc) (17701KB)(132)       Save
    The molecular mechanism underlying Corydalis Yanhusuo’s therapeutic potential in prostate cancer (PCa) treatment was  elucidated using network pharmacology and molecular docking. Nineteen active ingredients, 399 drug targets, 1790 disease  targets and 143 intersection targets were identified. Ten core targets were screened from the protein-protein interaction network.  Enrichment analysis revealed 133 GO terms and 114 KEGG pathways. Corydalis Yanhusuo may potentially treat prostate cancer  through pathways such as the Rap1 signaling pathway, phospholipase D signaling pathway, Ras signaling pathway, VEGF  signaling pathway and JAK-STAT signaling pathway. Significant differences in expression were observed for EGFR, PDGFRA,  PIK3CA, PIK3CD, PIK3CG and PIK3R1. Molecular docking and dynamics simulation analysis showed low binding energy  between active components and the six core genes of Corydalis Yanhusuo, indicating a favorable docking effect. This study shows  that Corydalis Yanhusuo exhibits promise in prostate cancer treatment through a synergistic “multi-component-multi-targetmulti-pathway” effect.
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    Analysis of vascular plant resources and diversity in Liupan Mountains of Ningxia Province, China
    Dongdong Wang, Minli Ruan, Jingming Jia, Anhua Wang
    Asian Journal of Traditional Medicines    2024, 19 (5): 266-274.  
    Abstract116)      PDF(pc) (371KB)(116)       Save
    Liupan Mountains are situated in the south of Ningxia Hui Autonomous Region and east of Gansu Province. This area is rich in  forests and vegetation. After field investigation, literature review and specimen identification, the plant resources and diversity  of Liupan Mountains were studied by the 4th Shenyang Pharmaceutical University Chinese Medicine Resources Scientific  Expedition Team. There were 161 species of vascular plants belonging to 60 families and 119 genera collected from July to August  2010 in this area. Among them, the dominant families are Campanulaceae, Ranunculaceae, Orobanchaceae, Asparagaceae,  Fabaceae, Rosaceae and Asteraceae, with 6, 7, 8, 8, 10, 10, and 22 species, respectively. Although representing only 11.7% of the  total number of families, these families had a species occupancy rate of over 44.1%. At the genus level, Pedicularis is the most  dominant genus with 6 species, while 92 genera contain only 1 species, accounting for 77.3% of the total number of genera. In a  word, our research has updated the plant resources and diversity in Liupan Mountains. Furthermore, by providing practical and  meaningful suggestions for strengthening the protection and utilization of plant resources in Liupan Mountains, our research is  of great significance for maintaining the diverse ecosystem in this area.
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    A review: Research progress on multi-target neuroprotective effects of n-butylphthalide  extracted from Apium graveolens seeds
    Jiahui Huo, Jingxian Ren, Xiaoxiao Huang, Xiaoliang Wang
    Asian Journal of Traditional Medicines    2024, 19 (5): 275-284.  
    Abstract19)      PDF(pc) (5286KB)(20)       Save
    Apium graveolens, an annual herb belonging to the family of Apiaceae, is widely distributed in North and South America,  Southern Europe, Africa and Asia. Apium graveolens seeds have a rich history in traditional Chinese medicine for treating  hypertension, headaches, vertigo and epilepsy. N-butylphthalide, originally extracted from Apium graveolens seeds, represents  a first-in-class drug developed independently in China. Its broad pharmacological activities on nervous system disorders have  garnered significant attention from researchers globally. This review focuses on the pharmacological research of n-butylphthalide  on central nervous system diseases, including ischemic stroke, Alzheimer’s disease, Parkinson’s disease and amyotrophic lateral  sclerosis. The purpose is to pave the way for future study on the mechanistic targets of n-butylphthalide.
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    Chemical composition and pharmacological activities of the Phellodendron chinense Schneid
    Yi′an Shi, Yunpeng Yang, Wenhan Wang, Yibo Wang, Yao Zhao, Yu Chen
    Asian Journal of Traditional Medicines    2024, 19 (5): 285-298.  
    Abstract124)      PDF(pc) (2443KB)(40)       Save
    Phellodendron chinense Schneid (P. chinense), as a traditional Chinese medicine, is commonly used in clinical practice. It has the  effects of drying dampness, clearing heat, detoxifying, purging fire, and reducing swelling. Its main chemical components are  flavonoids and alkaloids, which have various pharmacological effects such as lowering blood sugar, lowering blood pressure and  immunosuppression. With the continuous development of modern science and technology, the research on P. chinense Schneid  has increased. This study reviews the chemical components and pharmacological effects of P. chinense Schneid, and provides  reference for its further research and development.
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    Analysis of wild medicinal vascular plant resources and diversity in Dabie Mountains, Anhui Province
    Qing Wang, Minli Ruan, Anhua Wang, Jingming Jia
    Asian Journal of Traditional Medicines    2024, 19 (4): 192-210.  
    Abstract124)      PDF(pc) (887KB)(160)       Save
    Dabie Mountains are located at the junction of Anhui, Henan and Hubei provinces in the East of China. With its varied altitude,  climate, and soil texture, Dabie Mountains are extremely rich in wild plant resources. The 12th Traditional Chinese Medicine  (TCM) Resources Scientific Expedition Team of Shenyang Pharmaceutical University conducted a study on wild vascular plants  resources, especially medicinal vascular plants, through field investigation, literature review and specimen identification. There  were 472 species of vascular plants belonging to 347 genera and 125 families collected during July 2018 in this area, of which 424  species were medicinal vascular plants, accounting for 89.83% of the total. From the perspective of medicinal parts, most of the  medicinal plants there have values in their roots and rhizomes, as well as the whole plants. The efficacy and characteristics of  these pharmaceutical dimensions were also summarized and analyzed in detail. Besides, among the wild vascular plants collected,  the most dominant families with the biggest numbers of species are Compositae, Lamiaceae, Liliaceae, Rosaceae, Leguminosae,  Ranunculaceae, Saxifragaceae and Polygonaceae, and the dominant genus are Viola and Sedum. In terms of life form, perennial  herbs are dominant, accounting for 55.72% of the total species, followed by some annual (or biennial) herbs, shrubs and lianas.  Finally, recommendations are put forward for strengthening the protection and utilization of wild medicinal plant resources in Dabie Mountains.
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    Comprehensive analysis of phenolic composition and antioxidant mechanisms in Gymnema sylvestre extracts using LC-MS and column chromatography
    Shengjie Hao, Yuxin Du, Jianglong He, Qian Li, Guilin Chen
    Asian Journal of Traditional Medicines    2024, 19 (4): 211-222.  
    Abstract153)      PDF(pc) (2668KB)(388)       Save
    Recent studies have highlighted the potential of plant extracts as therapeutic agents for managing oxidative stress and related  disorders. This study aims to elucidate the phenolic composition and antioxidant properties of Gymnema sylvestre extracts.  Ethanolic reflux extraction followed by column chromatography was employed to isolate phenolic compounds. The total phenolic  and flavonoid contents were quantified using the Folin–Ciocalteu and aluminum chloride colorimetric methods, respectively.  Antioxidant activities were assessed by DPPH, ABTS scavenging assays and the ferric reducing antioxidant power (FRAP) assay.  High-Performance Liquid Chromatography (HPLC) with a C18 column and Thermo TSQ Quantum Access Max (LC-MS) were  used to determine the levels of gymnemic acid and identify other potential phenolic compounds. The analysis revealed significant  antioxidant activities in the fractions. Fraction A showed the highest DPPH and ABTS scavenging activities, and Fraction C  demonstrated the highest ferric reducing power. LC-MS analysis identified several phenolic compounds, indicating that these  are major contributors to the antioxidant efficacy of the extract. This study provides a detailed phenolic profile and confirms the  strong antioxidant potential of Gymnema sylvestre leaf extract, supporting its therapeutic use and further investigation.
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    Chemical composition and biological activity of Houttuynia cordata
    Yibo Wang, Yunpeng Yang, Xinyao Wang, Wenhan Wang, Luming Pan, Yu Chen
    Asian Journal of Traditional Medicines    2024, 19 (4): 223-234.  
    Abstract181)      PDF(pc) (6214KB)(134)       Save
    Houttuynia cordata is an important traditional Chinese medicine. It is widely used for clearing heat and detoxification, reducing  swelling and treating sores, diuresis and dehumidification. It is also used to treat lung carbuncles, ulcers, hemorrhoids,  rectal bleeding, spleen and stomach heat, which are caused by excess heat, heat toxicity, dampness, and disease heat. Modern  pharmacological experiments have shown that H. cordata has antibacterial, antiviral, immune enhancing, diuretic and other  effects. This article reviews the chemical components and biological activities of H. cordata to provide reference for clinical  application.
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    Network pharmacology to decipher the mechanism of Danggui  Longhui Wan against chronic myeloid leukemia
    Xuehan Ma, Qiulin Yan, Shaojiang Song, Guodong Yao
    Asian Journal of Traditional Medicines    2024, 19 (4): 177-191.  
    Abstract129)      PDF(pc) (92055KB)(40)       Save
    Chronic myeloid leukemia (CML) is a hematopoietic myeloproliferative disorder. The Chinese prescription Danggui Longhui  Wan (DGLHW) has been utilized in CML treatment, but its underlying mechanisms remain unclear. In this study, we gathered 794 constituents, 1249 drug targets, 1654 disease genes and 129 intersection genes. GO and KEGG were used to analyze the  function of these genes. Compatibility of prescription study showed that monarch drug, minister drug, assistant and guide drug  played a synergistic role in the treatment of CML. In addition, we obtained 20 hub genes and 12 key components. Molecular  docking indicated that the main compounds and core proteins had good binding ability. The results of this study also showed that  DGLHW might play a role in the treatment of CML by affecting MAPK, PI3K/AKT, FoxO and p53 signaling pathways.
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    Study on the mechanism of Euphorbia fischeriana Steud.-Jujubae Fructus in the treatment of hepatocirrhosis based on network pharmacology
    Yanqiong Luo, Bo Hong, Ronghong Liu, Yu Zou, Yujiao Hou, Wenjing Li
    Asian Journal of Traditional Medicines    2024, 19 (2): 51-65.  
    Abstract178)      PDF(pc) (6070KB)(557)       Save
    The active components, targets, and pathways of Euphorbia fischeriana Steud.-Jujubae Fructus in treating hepatocirrhosis and the mechanism of action were explored by means of network pharmacology. Firstly, the active components and related targets of Jujubae Fructus were screened by TCMSP database and standardized by Uniprot database. The compounds of Euphorbia fischeriana Steud. were obtained by searching the literature and finally screened by PubChem database, Swiss ADME, and SwissTargetPrediction. Hepatocirrhosis targets were obtained through Genecards database, PPI network analysis was conducted on common targets of Euphorbia fischeriana Steud.-Jujubae Fructus and hepatocirrhosis by using String database, GO enrichment analysis and KEGG pathway enrichment analysis was conducted through Metascape database by using intersection targets of Euphorbia fischeriana Steud.-Jujubae Fructus and hepatocirrhosis, and the results were drawn by using Weishengxin online drawing platform. Then, the network of drug-compound-target-pathway was constructed by the software of Cytoscape3.8.0. Finally, the above results were verified by molecular docking. 47 active compounds from Euphorbia fischeriana Steud.-Jujubae Fructus were screened out, which had 38 common targets, 162 intersection targets, and 340 signal pathways with hepatocirrhosis, mainly involving hepatitis C, JAK-STAT signal pathway and AGE-RAGE signal pathway. Targets, such as MAPK1, AKT1, TNF, JUN, IL6 and PTGS2, play important roles in the treatment. The findings suggested that the main active ingredients of Euphorbia fischeriana Steud.-Jujubae Fructus in treating hepatocirrhosis are quercetin, scopolamine, physcion, 7-deoxyrangduin, 17-Hydroxyjolkinolide A, etc. Molecular docking results showed that the main active components and core targets might have a good binding capacity. This study preliminarily explored the potential mechanism of Euphorbia fischeriana Steud.-Jujubae Fructus in treating hepatocirrhosis and provided a theoretical basis for the clinical application of Euphorbia fischeriana Steud.-Jujubae Fructus.
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    Analysis of plant resources and diversity in Shennongjia Area of Hubei Province, China
    Terigen Bao , Min Li , Jingming Jia, Anhua Wang
    Asian Journal of Traditional Medicines    2024, 19 (2): 66-87.  
    Abstract129)      PDF(pc) (45732KB)(27)       Save
    Shennongjia Area is located in northwest of Hubei Province with Shennongding, the highest peak (3105.4 m above sea level) in central China. The unique geographical location and complex terrain of this region make it rich in plant resources. After field investigation, literature review, and specimen identification, the 7th Shenyang Pharmaceutical University Chinese Medicine Resources Scientific Expedition Team studied the plant resources and diversity of Shennongjia Area. 454 species of vascular plants belonging to 106 families and 275 genera were collected from July to August in 2013. The dominant families are Lamiaceae, Ranunculaceae, Rosaceae, and Asteraceae, with 20, 21, 37 and 48 species respectively. At the genus level, Rubus is the dominant one with 11 species. 3 species of national first-class protective plants, 13 species of “Huan yang yao” and 36 species of “Qi yao” were collected. In all, our research has updated the plant recources and diversity in Shennongjia Area. Furthermore, by putting forward practical and meaningful suggestions on strengthening the protection and utilization of plant resources in Shennongjia Area, our research will help to protect the diverse ecosystem there.
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    Analysis of plant resources and diversity in the southeast area of Taihang Mountains
    Junpeng Lin, Jingming Jia, Anhua Wang
    Asian Journal of Traditional Medicines    2024, 19 (2): 88-98.  
    Abstract137)      PDF(pc) (941KB)(170)       Save
    Taihang Mountains are situated between Shanxi Province and the North China Plain, spanning Beijing, Hebei, Shanxi, and Henan provinces and cities. The mountains extend from northeast to southwest for over 400 km, naturally deviding the second step from the third one in China. The southeastern area of Taihang Mountains specifically refers to Changzhi City and Jincheng Administrative Region of Shanxi Province. Given Shanxi Province’s robust development plans for the southeast area of Taihang Mountains, the medicinal plant resources in this area will be affected. Therefore, it is imperative and urgent to conduct a comprehensive investigation and study on the medicinal plant resources in the southeast area of Taihang Mountains. By means of field investigation, literature review, and specimen identification, the plant resources and diversity of two counties in the southeast of Taihang Mountains were evaluated. The findings revealed 234 plants species across 172 genera in 70 families, primarily comprising angiosperms. The families with more species included Compositae, Leguminosae, Rosaceae, Labiatae, Ranunculaceae. Among the genera, those with more species were Cynanchum, Selaginella, Clematis, Thalictrum, and Rhamnus. A total of 114 medicinal plants were identified, constituting 48.72% of the total. Regarding medicinal parts, the concentration is in roots and rhizomes, followed by whole plants and fruits. On the basis of investigation and study, some suggestions on the development, utilization, and protection of medicinal plant resources in southeast Taihang Mountains were made. These suggestions provide valuable insights for the study on medicinal plant resources and vegetation in the southeast of Taihang Mountains, serving as a scientific basis for the protection and sustainable utilization of wild medicinal plant resources.
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    Chemical constituents and pharmacological effects of Croton crassifolius
    Luyan Yang, Yibo Wang, Xinyao Wang, Xiaoxia Xu , Yunpeng Yang, Meng Zhang, Yu Chen
    Asian Journal of Traditional Medicines    2024, 19 (2): 99-114.  
    Abstract152)      PDF(pc) (970KB)(128)       Save
    Croton crassifolius (CC) is a kind of traditional Chinese medicine rich in terpenoids, with among which diterpene species are the most. CC had biological activities in the treatment of cancer, inflammation, ulcerative colitis, osteoporosis and Alzheimer’s disease. This study reviews the chemical compositions and pharmacological activities of CC to provide reference for further research.
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    Protective effect of BlingLife®-berry extract on blue light-induced eye damage and its mechanism
    Jiaxiang Ding, Chenfeng Shou, Kexin Xie
    Asian Journal of Traditional Medicines    2024, 19 (1): 1-9.  
    Abstract334)      PDF(pc) (2200KB)(257)       Save
    This study aims to investigate the protective effects of BlingLife®-berry extract on the eyes. BlingLife®-berry extract is a mixture of high-quality natural berries, including blackcurrant, aromia, bilberry and maquiberry. The main active ingredient responsible for theeye-protective effects is anthocyanins. Anthocyanins are natural water-soluble pigments belonging to the flavonoid class, and theyhave multiple benefits, including improving vision, anti-inflammatory and antibacterial properties, and antioxidant effects. Dueto the dual benefits of anthocyanins in protecting vision and eliminating free radicals, this study explores the comprehensive eye protective effects of BlingLife®-berry extract in terms of combating blue light-induced eye damage and oxidative stress-inducedvisual fatigue. The results provide robust evidence for the in vivo effects and further technological
    applications of BlingLife®-berry extract.
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    Analysis of plant resources and diversity in Balluk Mountain, Xinjiang Uygur Autonomous Region
    Minli Ruan, Anhua Wang, Jingming Jia
    Asian Journal of Traditional Medicines    2024, 19 (1): 10-25.  
    Abstract167)      PDF(pc) (538KB)(643)       Save
    Balluk Mountain is located between the Tianshan Mountains and the Altai Mountains in Xinjiang Province. Influenced by the humid air and diverse landforms of Lake Alacuri, the unique climate of Mount Baluk nourishes excellent pastures and supports numerous wildlife, making it rich in plant resources. The 9th Shenyang Pharmaceutical University Chinese Medicine Resources Scientific Expedition Team conducted field investigations, literature reviews, and specimen identification to study the plant resources and diversity of Balluk Mountain in Xinjiang Province. A total of 235 species of medicinal plants belonging to 59 families and 159 genera were collected during the period from July to August 2015 in this area. The dominant families observed were Asteraceae, Caryophyllaceae, Lamiaceae, Ranunculaceae, Rosaceae and Umbelliferae, with 35, 11, 14, 12, 27, and
    13 species respectively. These families account for over 47.4% of the total species collected, though comprising only 10.2% of the total number of families. At the genus level, Artemisia was found to be the most dominant genus with eight species, contributing to 0.63% of the total genera, while representing 3.4% of the total species abundance. Overall, this study provides an updated analysis of the plant resources and diversity in Balluk Mountain. Several species have been identified to possess significant medicinal properties and hold potential for various research fields, including natural product chemistry and drug development. The study also offers practical and meaningful suggestions for strengthening the protection and utilization of plant resources in the area. By implementing these suggestions, we can better preserve the plant diversity in Balluk Mountain and ensure the sustainable use of these valuable resources.
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    Investigation and analysis of vascular plant resources and diversity in Wuyi Mountain, Fujian Province
    Peiying Chen, Ruru Xiong, Jun Yuan, Minglong Huang, Zhuo Tao, Bowen Zhang, Fanglin Luo, Lisha Liu, Qian Wang, You Zhou, Haofan Zhang, Zijie Wei, Jie Yang, Jiangang Chen, Kui Wu, Anhua Wang, Jingming Jia
    Asian Journal of Traditional Medicines    2024, 19 (1): 26-33.  
    Abstract185)      PDF(pc) (632KB)(566)       Save
    Wuyi Mountain, located in the north of Fujian Province, China, is renowned for its abundant medicinal plant resources. In July 2014, the 8th (second team) of Shenyang Pharmaceutical University’s Chinese Medicine Resources Scientific Expedition Team conducted field investigation in the area. Through specimen collection and extensive literature review, the team identified and analyzed 223 vascular plant species from 175 genera and 85 families. The most dominant families were Compositae and Rosaceae, and perennial herbs were the predominant species, accounting for 44.39% of the total species identified. Notably, we documented five precious and rare medicinal plants unique to Wuyi Mountain. This study updates the database of plant resources and diversity in the region, providing a valuable reference for future studies. Finally, we put forward some suggestions to enhance the conservation and sustainable utilization of Wuyi Mountain’s plant resources.
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    Chemical constituents and pharmacological effects of Lonicerae japonicae
    Yunpeng Yang# , Dan Tian# , Yibo Wang, Yi’an Shi, Yuntian Xing, Yu Chen
    Asian Journal of Traditional Medicines    2024, 19 (1): 34-45.  
    Abstract208)      PDF(pc) (1416KB)(197)       Save
    Lonicera japonica, also known as honeysuckle, is an evergreen shrub in the family of Syzygium. By consulting Sciencedirect databases and Web of Science databases, 79 related articles were found, of which 22 were related to chemical composition and pharmacological activity. These articles show that L. japonica has a wide range of pharmacological activities, including antiviral, anti-tumor, and antioxidant effects. These activities have important applications in the pharmaceutical, food, and fragrance industries. This review focuses on the chemical composition and pharmacological effects of L. japonicae, which is of great significance to the development of new drugs and therapeutic methods.
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    Analysis of wild vascular plant resources and diversity in Taibai Mountains of Qinling area, Shaanxi Province
    Bingjun Sun , Qing Wang , Minli Ruan, Anhua Wang, Jingming Jia
    Asian Journal of Traditional Medicines    2023, 18 (6): 253-270.  
    Abstract174)      PDF(pc) (4931KB)(847)       Save
    Taibai Mountains, located at the northern foot of the Qinling Mountains, are composed of the Yuan Taibai Mountain (also known as East Taibai Mountain), Aoshan Mountain (also known as West Taibai Mountain) and their connection part. With its complex geographical and climatic conditions, Taibai Mountains are extremely rich in wild plant resources. Based on field investigation, literature review and specimen identification, wild vascular plants resources and their diversity in Taibai Mountains were studied by the sixth Traditional Chinese Medicine (TCM) Resources Scientific Expedition Team of Shenyang Pharmaceutical University. 222 species of vascular plants belonging to 163 genera and 63 families were collected during July 2012 in this area, and most of the plants are angiosperms. The families with more species are Liliaceae, Ranunculaceae, Asteraceae, Rosaceae, and Saxifragaceae, and the dominant genus are Aconitum, Sedum, Eleutherococcus, Pedicularis, Polygonatum, and Patrinia. In terms of life form, perennial herbs are the main species, accounting for 72.97% of the total species, with others being some annual (or biennial) herbs, shrubs and lianas. Among all the collected vascular plants, 170 species of them are medicinal vascular plants, accounting for 76.58% of the total. Most of the medicinal parts are roots and rhizomes, followed by the whole plants. Finally, on the basis of investigation and study, some suggestions are put forward to strengthen the protection and utilization of plant resources in Taibai Mountains.
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    Analysis of vascular plant resources and diversity in Machin County, Qinghai Province
    Hu Chen, Dongdong Wang, Qing Wang, Anhua Wang, Jingming Jia
    Asian Journal of Traditional Medicines    2023, 18 (6): 271-279.  
    Abstract133)      PDF(pc) (1240KB)(260)       Save
    Machin County is situated in the Sanjiangyuan Nature Reserve in the southeastern part of Qinghai Province. Influenced by the special topography and climate of the Qinghai-Tibet Plateau, Machin County has complex and diverse plant species. The vascular plant resources and diversity in Machin County were studied through field survey, literature review and specimen identification. The results show that there are 47 families and 127 genera and 256 species of vascular plants in the region, basically angiosperms, including those containing more species of the family Asteraceae, Buttercup, Genus Ginseng, Leguminosae and Rosaceae, and those containing more species of the genus Artemisia, Artemisia, Aster and Donzonia. In terms of life type, perennial herbs are the most dominant ones, accounting for 77.34% of the total number of species, followed by some annual (or biennial) herbs and shrub types. There are 191 species of medicinal vascular plants, accounting for 74.61% of the total number of species, including 48 species of Tibetan medicine. In terms of the medicinal parts of these plants, whole herb category is the most common one, followed by the root and rhizome category. Based on the investigation and research, we have proposed the conservation and utilization of plant resources in Machin County, Qinghai Province.
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    Chemical composition and biological activities of volatile oil isolated from Curcumae rhizoma
    Wenhan Wang, Yibo Wang, Yuntian Xing, Xinyao Wang, Guanyi Zhao, Yu Chen
    Asian Journal of Traditional Medicines    2023, 18 (6): 280-288.  
    Abstract184)      PDF(pc) (1008KB)(146)       Save
    Curcumae rhizoma (C. rhizoma), the rhizome of Curcuma Longa L., Curcuma kwangsiensis L. and Curcuma wenyujin L. in the ginger family, is a treasure in traditional Chinese medicine. It has the effect of promoting qi and breaking blood, eliminating accumulation and relieving pain. With the development of modern medicine, the active ingredients and therapeutic mechanism of C. rhizoma have been gradually revealed. In this paper, the chemical composition and biological activities of volatile oil isolated from C. rhizoma are reviewed in detail, aiming to provide reference for further utilization of C. rhizoma volatile oil and provide more effective drug options for clinical treatment.

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