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    The mechanism analysis of KangBingDuKouFuYe in treating throat infection based on network pharmacology and molecular docking
    Ying Long# , Xinhui Yang# , Hongfei Lv, Zhenyu Liu, Tianjun Guo, Chaohui Yang, Hui Liu, Qijia Yang, Xin Wu
    Asian Journal of Traditional Medicines    2025, 20 (1): 1-13.  
    Abstract65)      PDF(pc) (14358KB)(27)       Save
    KangBingDuKouFuYe (KBDKFY) is widely used to treat inffuenza, upper respiratory tract infections, mumps and other diseases. Due to their diverse active ingredients, it is believed that they may have excellent anti-inflammatory, antibacterial and antiviral effects. Therefore, we believe they may have multiple therapeutic targets for throat inflammation caused by bacterial or viral infections. This study utilizes network pharmacology methods to analyze the therapeutic effects of KBDKFY on Bacterial Pharyngeal Tonsillitis and Viral Pharyngitis, aiming to identify its active ingredients, action targets and related pathways through molecular docking. Additionally, it determines the afffnity between the main active ingredient and the core target before conducting in vitro bacteriostatic tests. The analysis results show that KBDKFY contains multiple active ingredients and potential targets for treating Bacterial Pharyngeal Tonsillitis and Viral Pharyngitis. KEGG enrichment analysis indicates that KBDKFY may have therapeutic effects on these conditions through pathways such as pathways in cancer, Kaposi sarcoma-associated herpesvirus infection, PI3K-Akt signaling pathway, and others. This provides a theoretical basis for further exploring pharmacological effects and clinical applications of KBDKFY.
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    Chemical composition and biological activities of Lysimachia capillipes Hemsl
    Ran Guo, Ruoming Li, Xiaomeng Zhang, Wenhan Wang, Yao Zhao, Yu Chen
    Asian Journal of Traditional Medicines    2025, 20 (1): 14-29.  
    Abstract30)      PDF(pc) (5618KB)(24)       Save
    Lysimachia capillipes (L. capillipes) Hemsl, belong to primulaceae pearl vegetables genus, is a treasure in traditional Chinese medicine. It has the effects of invigorating qi and tonifying deffciency, dispelling wind and activating blood, awakening the brain, relieving cough and regulating menstruation. With the development of modern medicine, the active components and therapeutic mechanisms of L. capillipes Hemsl have been gradually revealed. The present report systematically reviews the chemical composition and biological activities of L. capillipes Hemsl, to provide scientiffc basis and reference for detailed research on L. capillipes Hemsl.
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    Research progress of different kinds of traditional Chinese medicine in the treatment of type 2 diabetes
    Yuzheng Xiang, Xiaomeng Zhang, Ruoming Li, Wenhan Wang, Yao Zhao, Yu Chen
    Asian Journal of Traditional Medicines    2025, 20 (1): 30-42.  
    Abstract28)      PDF(pc) (17418KB)(18)       Save
    type 2 diabetes; traditional Chinese medicine; research progress
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    Analysis of plant resources and diversity in some areas of Inner Mongolia, China
    Terigen Bao, Minli, Jingming Jia , Anhua Wang
    Asian Journal of Traditional Medicines    2024, 19 (6): 321-333.  
    Abstract39)      PDF(pc) (390KB)(30)       Save
    Inner Mongolia Autonomous Region is located in the north of China. The vast area and complex terrain of this region make it rich in plant resources. The 11th Shenyang Pharmaceutical University Chinese Medicine Resources Scientific Expedition Team investigated the plant resources and diversity in some areas of Inner Mongolia through field investigation, literature review and specimen identification. From July to August, 2017, 215 species of vascular plants belonging to 59 families and 160 genera were collected. The dominant families are RanunculaceaeLamiaceaeRosaceaeFabaceae and Asteraceae, with 11, 12, 15, 19, and 37 species, respectively. There are 55 families, 132 genera and 163 species of medical plant recources in some areas of Inner Mongolia. 27 vascular plants are Mongolian Medicine. In a word, our research has updated the plant recources and diversity in all areas of Inner Mongolia. Furthermore, this study provides practical and meaningful suggestions for strengthening the protection and utilization of plant resources in some areas of Inner Mongolia, which is of great significance for maintaining local plant diversity.
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    Review on Croton crassifolius: From botanical characteristics to biotransformation and better utilization
    Guoyu Wang, Wenhan Wang, Xiaomeng Zhang, Yunpeng Yang, Yibo Wang, Yao Zhao , Yu Chen
    Asian Journal of Traditional Medicines    2024, 19 (6): 334-341.  
    Abstract27)      PDF(pc) (6252KB)(20)       Save
    Croton crassifolius (C. crassifolius) is a kind of traditional Chinese medicine, with a history hundreds of years in China. By consulting Sciencedirect databases and Web of Science databases, 68 related articles were found, 12 of which were related to chemical composition and pharmacological activity. It was used by the ancients as the medicine to treat stomach trouble, rheumatism, poliomyelitis and injuries, and it is the treasure of traditional Chinese medicine in China. With the development of  modern medicine, the active ingredients and therapeutic mechanism of C. crassifolius have been gradually revealed. In this study, the functions and applications of C. crassifolius were reviewed from the aspects of botany, traditional Chinese medicine therapy and biotransformation of substances, so as to better understand and use C. crassifolius and provide more effective drug choices for clinical treatment.
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    Chemical compositions and pharmacological activities of Xanthium strumarium
    Ruoming Li, Yunpeng Yang, Xiaomeng Zhang, Yibo Wang, Wenhan Wang, Yao Zhao , Yu Chen
    Asian Journal of Traditional Medicines    2024, 19 (6): 342-352.  
    Abstract32)      PDF(pc) (3742KB)(21)       Save
    Xanthium strumarium (X. strumarium) is a traditional Chinese medicine with a long history. In recent years, with the development of modern pharmacology and chemical analysis technology, research on X. strumarium has been deepend. This paper aims to systematically summarize the chemical compositions and pharmacological effects of X. strumarium, in order to provide theoretical basis and reference for further exploration in its clinical application and drug development.
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    Quantitative analysis of Cefpodoxime Proxetil raw material and dry suspension using proton nuclear magnetic resonance
    Yufei Liu, Bin Li, Xinyu Tao, Dongyang Zhao, Xinyu Zhang, Yan Wu, Wenyi He, Chenggen Zhu, Xiangju Jin, Hongyue Liu, Xin Di, Ye Tian, Yanan Wang
    Asian Journal of Traditional Medicines    2024, 19 (6): 305-320.  
    Abstract48)      PDF(pc) (4367KB)(41)       Save
    This study established a simple, rapid, and accurate nuclear magnetic resonance (NMR) quantitative method to determine the cefpodoxime proxetil content in raw materials and dry suspensions, and evaluated the uncertainty. The relative content of cefpodoxime proxetil iso-A and iso-B was also analyzed based on 1 H NMR. In this study, an internal standard method was used, with DMSO-d 6 as the solvent and maleic acid and 1,3,5-trimethylbenzene as internal standards, to calculate the concentration of the samples. Quantitative analysis was performed using both the traditional quantitative NMR (traditional qNMR) and the quantitative Global Spectral Deconvolution (qGSD) method. The linearity range, quantitation limit, precision, robustness, and accuracy of these quantitative analysis methods were validated. The results indicated that both internal standards and integration methods met the requirements of the “9101 Guidelines for Analytical Method Validation” in the 2020 edition of the Chinese Pharmacopoeia. Compared to the traditional qNMR, qGSD has unique advantages in accurate quantitative analysis in complex systems. By using the combined HPLC-SPE-NMR technique, cefpodoxime proxetil iso-A and iso-B were enriched and analyzed, and their NMR data were accurately assigned. The quantitative analysis results were in line with the requirements of the Chinese Pharmacopoeia.
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    Exploring the molecular mechanism of Corydalis yanhusuo against prostate cancer based on network pharmacology and molecular docking validation
    Ying Zhu#, Junwei Lu#, Jumin Xie
    Asian Journal of Traditional Medicines    2024, 19 (5): 241-265.  
    Abstract70)      PDF(pc) (17701KB)(43)       Save
    The molecular mechanism underlying Corydalis Yanhusuo’s therapeutic potential in prostate cancer (PCa) treatment was  elucidated using network pharmacology and molecular docking. Nineteen active ingredients, 399 drug targets, 1790 disease  targets and 143 intersection targets were identified. Ten core targets were screened from the protein-protein interaction network.  Enrichment analysis revealed 133 GO terms and 114 KEGG pathways. Corydalis Yanhusuo may potentially treat prostate cancer  through pathways such as the Rap1 signaling pathway, phospholipase D signaling pathway, Ras signaling pathway, VEGF  signaling pathway and JAK-STAT signaling pathway. Significant differences in expression were observed for EGFR, PDGFRA,  PIK3CA, PIK3CD, PIK3CG and PIK3R1. Molecular docking and dynamics simulation analysis showed low binding energy  between active components and the six core genes of Corydalis Yanhusuo, indicating a favorable docking effect. This study shows  that Corydalis Yanhusuo exhibits promise in prostate cancer treatment through a synergistic “multi-component-multi-targetmulti-pathway” effect.
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    Analysis of vascular plant resources and diversity in Liupan Mountains of Ningxia Province, China
    Dongdong Wang, Minli Ruan, Jingming Jia, Anhua Wang
    Asian Journal of Traditional Medicines    2024, 19 (5): 266-274.  
    Abstract57)      PDF(pc) (371KB)(23)       Save
    Liupan Mountains are situated in the south of Ningxia Hui Autonomous Region and east of Gansu Province. This area is rich in  forests and vegetation. After field investigation, literature review and specimen identification, the plant resources and diversity  of Liupan Mountains were studied by the 4th Shenyang Pharmaceutical University Chinese Medicine Resources Scientific  Expedition Team. There were 161 species of vascular plants belonging to 60 families and 119 genera collected from July to August  2010 in this area. Among them, the dominant families are Campanulaceae, Ranunculaceae, Orobanchaceae, Asparagaceae,  Fabaceae, Rosaceae and Asteraceae, with 6, 7, 8, 8, 10, 10, and 22 species, respectively. Although representing only 11.7% of the  total number of families, these families had a species occupancy rate of over 44.1%. At the genus level, Pedicularis is the most  dominant genus with 6 species, while 92 genera contain only 1 species, accounting for 77.3% of the total number of genera. In a  word, our research has updated the plant resources and diversity in Liupan Mountains. Furthermore, by providing practical and  meaningful suggestions for strengthening the protection and utilization of plant resources in Liupan Mountains, our research is  of great significance for maintaining the diverse ecosystem in this area.
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    A review: Research progress on multi-target neuroprotective effects of n-butylphthalide  extracted from Apium graveolens seeds
    Jiahui Huo, Jingxian Ren, Xiaoxiao Huang, Xiaoliang Wang
    Asian Journal of Traditional Medicines    2024, 19 (5): 275-284.  
    Abstract0)      PDF(pc) (5286KB)(0)       Save
    Apium graveolens, an annual herb belonging to the family of Apiaceae, is widely distributed in North and South America,  Southern Europe, Africa and Asia. Apium graveolens seeds have a rich history in traditional Chinese medicine for treating  hypertension, headaches, vertigo and epilepsy. N-butylphthalide, originally extracted from Apium graveolens seeds, represents  a first-in-class drug developed independently in China. Its broad pharmacological activities on nervous system disorders have  garnered significant attention from researchers globally. This review focuses on the pharmacological research of n-butylphthalide  on central nervous system diseases, including ischemic stroke, Alzheimer’s disease, Parkinson’s disease and amyotrophic lateral  sclerosis. The purpose is to pave the way for future study on the mechanistic targets of n-butylphthalide.
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    Chemical composition and pharmacological activities of the Phellodendron chinense Schneid
    Yi′an Shi, Yunpeng Yang, Wenhan Wang, Yibo Wang, Yao Zhao, Yu Chen
    Asian Journal of Traditional Medicines    2024, 19 (5): 285-298.  
    Abstract44)      PDF(pc) (2443KB)(27)       Save
    Phellodendron chinense Schneid (P. chinense), as a traditional Chinese medicine, is commonly used in clinical practice. It has the  effects of drying dampness, clearing heat, detoxifying, purging fire, and reducing swelling. Its main chemical components are  flavonoids and alkaloids, which have various pharmacological effects such as lowering blood sugar, lowering blood pressure and  immunosuppression. With the continuous development of modern science and technology, the research on P. chinense Schneid  has increased. This study reviews the chemical components and pharmacological effects of P. chinense Schneid, and provides  reference for its further research and development.
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    Analysis of wild medicinal vascular plant resources and diversity in Dabie Mountains, Anhui Province
    Qing Wang, Minli Ruan, Anhua Wang, Jingming Jia
    Asian Journal of Traditional Medicines    2024, 19 (4): 192-210.  
    Abstract57)      PDF(pc) (887KB)(62)       Save
    Dabie Mountains are located at the junction of Anhui, Henan and Hubei provinces in the East of China. With its varied altitude,  climate, and soil texture, Dabie Mountains are extremely rich in wild plant resources. The 12th Traditional Chinese Medicine  (TCM) Resources Scientific Expedition Team of Shenyang Pharmaceutical University conducted a study on wild vascular plants  resources, especially medicinal vascular plants, through field investigation, literature review and specimen identification. There  were 472 species of vascular plants belonging to 347 genera and 125 families collected during July 2018 in this area, of which 424  species were medicinal vascular plants, accounting for 89.83% of the total. From the perspective of medicinal parts, most of the  medicinal plants there have values in their roots and rhizomes, as well as the whole plants. The efficacy and characteristics of  these pharmaceutical dimensions were also summarized and analyzed in detail. Besides, among the wild vascular plants collected,  the most dominant families with the biggest numbers of species are Compositae, Lamiaceae, Liliaceae, Rosaceae, Leguminosae,  Ranunculaceae, Saxifragaceae and Polygonaceae, and the dominant genus are Viola and Sedum. In terms of life form, perennial  herbs are dominant, accounting for 55.72% of the total species, followed by some annual (or biennial) herbs, shrubs and lianas.  Finally, recommendations are put forward for strengthening the protection and utilization of wild medicinal plant resources in Dabie Mountains.
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    Comprehensive analysis of phenolic composition and antioxidant mechanisms in Gymnema sylvestre extracts using LC-MS and column chromatography
    Shengjie Hao, Yuxin Du, Jianglong He, Qian Li, Guilin Chen
    Asian Journal of Traditional Medicines    2024, 19 (4): 211-222.  
    Abstract74)      PDF(pc) (2668KB)(273)       Save
    Recent studies have highlighted the potential of plant extracts as therapeutic agents for managing oxidative stress and related  disorders. This study aims to elucidate the phenolic composition and antioxidant properties of Gymnema sylvestre extracts.  Ethanolic reflux extraction followed by column chromatography was employed to isolate phenolic compounds. The total phenolic  and flavonoid contents were quantified using the Folin–Ciocalteu and aluminum chloride colorimetric methods, respectively.  Antioxidant activities were assessed by DPPH, ABTS scavenging assays and the ferric reducing antioxidant power (FRAP) assay.  High-Performance Liquid Chromatography (HPLC) with a C18 column and Thermo TSQ Quantum Access Max (LC-MS) were  used to determine the levels of gymnemic acid and identify other potential phenolic compounds. The analysis revealed significant  antioxidant activities in the fractions. Fraction A showed the highest DPPH and ABTS scavenging activities, and Fraction C  demonstrated the highest ferric reducing power. LC-MS analysis identified several phenolic compounds, indicating that these  are major contributors to the antioxidant efficacy of the extract. This study provides a detailed phenolic profile and confirms the  strong antioxidant potential of Gymnema sylvestre leaf extract, supporting its therapeutic use and further investigation.
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    Chemical composition and biological activity of Houttuynia cordata
    Yibo Wang, Yunpeng Yang, Xinyao Wang, Wenhan Wang, Luming Pan, Yu Chen
    Asian Journal of Traditional Medicines    2024, 19 (4): 223-234.  
    Abstract59)      PDF(pc) (6214KB)(50)       Save
    Houttuynia cordata is an important traditional Chinese medicine. It is widely used for clearing heat and detoxification, reducing  swelling and treating sores, diuresis and dehumidification. It is also used to treat lung carbuncles, ulcers, hemorrhoids,  rectal bleeding, spleen and stomach heat, which are caused by excess heat, heat toxicity, dampness, and disease heat. Modern  pharmacological experiments have shown that H. cordata has antibacterial, antiviral, immune enhancing, diuretic and other  effects. This article reviews the chemical components and biological activities of H. cordata to provide reference for clinical  application.
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    Network pharmacology to decipher the mechanism of Danggui  Longhui Wan against chronic myeloid leukemia
    Xuehan Ma, Qiulin Yan, Shaojiang Song, Guodong Yao
    Asian Journal of Traditional Medicines    2024, 19 (4): 177-191.  
    Abstract55)      PDF(pc) (92055KB)(32)       Save
    Chronic myeloid leukemia (CML) is a hematopoietic myeloproliferative disorder. The Chinese prescription Danggui Longhui  Wan (DGLHW) has been utilized in CML treatment, but its underlying mechanisms remain unclear. In this study, we gathered 794 constituents, 1249 drug targets, 1654 disease genes and 129 intersection genes. GO and KEGG were used to analyze the  function of these genes. Compatibility of prescription study showed that monarch drug, minister drug, assistant and guide drug  played a synergistic role in the treatment of CML. In addition, we obtained 20 hub genes and 12 key components. Molecular  docking indicated that the main compounds and core proteins had good binding ability. The results of this study also showed that  DGLHW might play a role in the treatment of CML by affecting MAPK, PI3K/AKT, FoxO and p53 signaling pathways.
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    Study on the mechanism of Euphorbia fischeriana Steud.-Jujubae Fructus in the treatment of hepatocirrhosis based on network pharmacology
    Yanqiong Luo, Bo Hong, Ronghong Liu, Yu Zou, Yujiao Hou, Wenjing Li
    Asian Journal of Traditional Medicines    2024, 19 (2): 51-65.  
    Abstract113)      PDF(pc) (6070KB)(270)       Save
    The active components, targets, and pathways of Euphorbia fischeriana Steud.-Jujubae Fructus in treating hepatocirrhosis and the mechanism of action were explored by means of network pharmacology. Firstly, the active components and related targets of Jujubae Fructus were screened by TCMSP database and standardized by Uniprot database. The compounds of Euphorbia fischeriana Steud. were obtained by searching the literature and finally screened by PubChem database, Swiss ADME, and SwissTargetPrediction. Hepatocirrhosis targets were obtained through Genecards database, PPI network analysis was conducted on common targets of Euphorbia fischeriana Steud.-Jujubae Fructus and hepatocirrhosis by using String database, GO enrichment analysis and KEGG pathway enrichment analysis was conducted through Metascape database by using intersection targets of Euphorbia fischeriana Steud.-Jujubae Fructus and hepatocirrhosis, and the results were drawn by using Weishengxin online drawing platform. Then, the network of drug-compound-target-pathway was constructed by the software of Cytoscape3.8.0. Finally, the above results were verified by molecular docking. 47 active compounds from Euphorbia fischeriana Steud.-Jujubae Fructus were screened out, which had 38 common targets, 162 intersection targets, and 340 signal pathways with hepatocirrhosis, mainly involving hepatitis C, JAK-STAT signal pathway and AGE-RAGE signal pathway. Targets, such as MAPK1, AKT1, TNF, JUN, IL6 and PTGS2, play important roles in the treatment. The findings suggested that the main active ingredients of Euphorbia fischeriana Steud.-Jujubae Fructus in treating hepatocirrhosis are quercetin, scopolamine, physcion, 7-deoxyrangduin, 17-Hydroxyjolkinolide A, etc. Molecular docking results showed that the main active components and core targets might have a good binding capacity. This study preliminarily explored the potential mechanism of Euphorbia fischeriana Steud.-Jujubae Fructus in treating hepatocirrhosis and provided a theoretical basis for the clinical application of Euphorbia fischeriana Steud.-Jujubae Fructus.
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    Analysis of plant resources and diversity in Shennongjia Area of Hubei Province, China
    Terigen Bao , Min Li , Jingming Jia, Anhua Wang
    Asian Journal of Traditional Medicines    2024, 19 (2): 66-87.  
    Abstract56)      PDF(pc) (45732KB)(24)       Save
    Shennongjia Area is located in northwest of Hubei Province with Shennongding, the highest peak (3105.4 m above sea level) in central China. The unique geographical location and complex terrain of this region make it rich in plant resources. After field investigation, literature review, and specimen identification, the 7th Shenyang Pharmaceutical University Chinese Medicine Resources Scientific Expedition Team studied the plant resources and diversity of Shennongjia Area. 454 species of vascular plants belonging to 106 families and 275 genera were collected from July to August in 2013. The dominant families are Lamiaceae, Ranunculaceae, Rosaceae, and Asteraceae, with 20, 21, 37 and 48 species respectively. At the genus level, Rubus is the dominant one with 11 species. 3 species of national first-class protective plants, 13 species of “Huan yang yao” and 36 species of “Qi yao” were collected. In all, our research has updated the plant recources and diversity in Shennongjia Area. Furthermore, by putting forward practical and meaningful suggestions on strengthening the protection and utilization of plant resources in Shennongjia Area, our research will help to protect the diverse ecosystem there.
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    Analysis of plant resources and diversity in the southeast area of Taihang Mountains
    Junpeng Lin, Jingming Jia, Anhua Wang
    Asian Journal of Traditional Medicines    2024, 19 (2): 88-98.  
    Abstract63)      PDF(pc) (941KB)(94)       Save
    Taihang Mountains are situated between Shanxi Province and the North China Plain, spanning Beijing, Hebei, Shanxi, and Henan provinces and cities. The mountains extend from northeast to southwest for over 400 km, naturally deviding the second step from the third one in China. The southeastern area of Taihang Mountains specifically refers to Changzhi City and Jincheng Administrative Region of Shanxi Province. Given Shanxi Province’s robust development plans for the southeast area of Taihang Mountains, the medicinal plant resources in this area will be affected. Therefore, it is imperative and urgent to conduct a comprehensive investigation and study on the medicinal plant resources in the southeast area of Taihang Mountains. By means of field investigation, literature review, and specimen identification, the plant resources and diversity of two counties in the southeast of Taihang Mountains were evaluated. The findings revealed 234 plants species across 172 genera in 70 families, primarily comprising angiosperms. The families with more species included Compositae, Leguminosae, Rosaceae, Labiatae, Ranunculaceae. Among the genera, those with more species were Cynanchum, Selaginella, Clematis, Thalictrum, and Rhamnus. A total of 114 medicinal plants were identified, constituting 48.72% of the total. Regarding medicinal parts, the concentration is in roots and rhizomes, followed by whole plants and fruits. On the basis of investigation and study, some suggestions on the development, utilization, and protection of medicinal plant resources in southeast Taihang Mountains were made. These suggestions provide valuable insights for the study on medicinal plant resources and vegetation in the southeast of Taihang Mountains, serving as a scientific basis for the protection and sustainable utilization of wild medicinal plant resources.
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    Chemical constituents and pharmacological effects of Croton crassifolius
    Luyan Yang, Yibo Wang, Xinyao Wang, Xiaoxia Xu , Yunpeng Yang, Meng Zhang, Yu Chen
    Asian Journal of Traditional Medicines    2024, 19 (2): 99-114.  
    Abstract72)      PDF(pc) (970KB)(73)       Save
    Croton crassifolius (CC) is a kind of traditional Chinese medicine rich in terpenoids, with among which diterpene species are the most. CC had biological activities in the treatment of cancer, inflammation, ulcerative colitis, osteoporosis and Alzheimer’s disease. This study reviews the chemical compositions and pharmacological activities of CC to provide reference for further research.
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    Protective effect of BlingLife®-berry extract on blue light-induced eye damage and its mechanism
    Jiaxiang Ding, Chenfeng Shou, Kexin Xie
    Asian Journal of Traditional Medicines    2024, 19 (1): 1-9.  
    Abstract213)      PDF(pc) (2200KB)(179)       Save
    This study aims to investigate the protective effects of BlingLife®-berry extract on the eyes. BlingLife®-berry extract is a mixture of high-quality natural berries, including blackcurrant, aromia, bilberry and maquiberry. The main active ingredient responsible for theeye-protective effects is anthocyanins. Anthocyanins are natural water-soluble pigments belonging to the flavonoid class, and theyhave multiple benefits, including improving vision, anti-inflammatory and antibacterial properties, and antioxidant effects. Dueto the dual benefits of anthocyanins in protecting vision and eliminating free radicals, this study explores the comprehensive eye protective effects of BlingLife®-berry extract in terms of combating blue light-induced eye damage and oxidative stress-inducedvisual fatigue. The results provide robust evidence for the in vivo effects and further technological
    applications of BlingLife®-berry extract.
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    Analysis of plant resources and diversity in Balluk Mountain, Xinjiang Uygur Autonomous Region
    Minli Ruan, Anhua Wang, Jingming Jia
    Asian Journal of Traditional Medicines    2024, 19 (1): 10-25.  
    Abstract94)      PDF(pc) (538KB)(136)       Save
    Balluk Mountain is located between the Tianshan Mountains and the Altai Mountains in Xinjiang Province. Influenced by the humid air and diverse landforms of Lake Alacuri, the unique climate of Mount Baluk nourishes excellent pastures and supports numerous wildlife, making it rich in plant resources. The 9th Shenyang Pharmaceutical University Chinese Medicine Resources Scientific Expedition Team conducted field investigations, literature reviews, and specimen identification to study the plant resources and diversity of Balluk Mountain in Xinjiang Province. A total of 235 species of medicinal plants belonging to 59 families and 159 genera were collected during the period from July to August 2015 in this area. The dominant families observed were Asteraceae, Caryophyllaceae, Lamiaceae, Ranunculaceae, Rosaceae and Umbelliferae, with 35, 11, 14, 12, 27, and
    13 species respectively. These families account for over 47.4% of the total species collected, though comprising only 10.2% of the total number of families. At the genus level, Artemisia was found to be the most dominant genus with eight species, contributing to 0.63% of the total genera, while representing 3.4% of the total species abundance. Overall, this study provides an updated analysis of the plant resources and diversity in Balluk Mountain. Several species have been identified to possess significant medicinal properties and hold potential for various research fields, including natural product chemistry and drug development. The study also offers practical and meaningful suggestions for strengthening the protection and utilization of plant resources in the area. By implementing these suggestions, we can better preserve the plant diversity in Balluk Mountain and ensure the sustainable use of these valuable resources.
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    Investigation and analysis of vascular plant resources and diversity in Wuyi Mountain, Fujian Province
    Peiying Chen, Ruru Xiong, Jun Yuan, Minglong Huang, Zhuo Tao, Bowen Zhang, Fanglin Luo, Lisha Liu, Qian Wang, You Zhou, Haofan Zhang, Zijie Wei, Jie Yang, Jiangang Chen, Kui Wu, Anhua Wang, Jingming Jia
    Asian Journal of Traditional Medicines    2024, 19 (1): 26-33.  
    Abstract100)      PDF(pc) (632KB)(81)       Save
    Wuyi Mountain, located in the north of Fujian Province, China, is renowned for its abundant medicinal plant resources. In July 2014, the 8th (second team) of Shenyang Pharmaceutical University’s Chinese Medicine Resources Scientific Expedition Team conducted field investigation in the area. Through specimen collection and extensive literature review, the team identified and analyzed 223 vascular plant species from 175 genera and 85 families. The most dominant families were Compositae and Rosaceae, and perennial herbs were the predominant species, accounting for 44.39% of the total species identified. Notably, we documented five precious and rare medicinal plants unique to Wuyi Mountain. This study updates the database of plant resources and diversity in the region, providing a valuable reference for future studies. Finally, we put forward some suggestions to enhance the conservation and sustainable utilization of Wuyi Mountain’s plant resources.
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    Chemical constituents and pharmacological effects of Lonicerae japonicae
    Yunpeng Yang# , Dan Tian# , Yibo Wang, Yi’an Shi, Yuntian Xing, Yu Chen
    Asian Journal of Traditional Medicines    2024, 19 (1): 34-45.  
    Abstract128)      PDF(pc) (1416KB)(129)       Save
    Lonicera japonica, also known as honeysuckle, is an evergreen shrub in the family of Syzygium. By consulting Sciencedirect databases and Web of Science databases, 79 related articles were found, of which 22 were related to chemical composition and pharmacological activity. These articles show that L. japonica has a wide range of pharmacological activities, including antiviral, anti-tumor, and antioxidant effects. These activities have important applications in the pharmaceutical, food, and fragrance industries. This review focuses on the chemical composition and pharmacological effects of L. japonicae, which is of great significance to the development of new drugs and therapeutic methods.
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    Analysis of wild vascular plant resources and diversity in Taibai Mountains of Qinling area, Shaanxi Province
    Bingjun Sun , Qing Wang , Minli Ruan, Anhua Wang, Jingming Jia
    Asian Journal of Traditional Medicines    2023, 18 (6): 253-270.  
    Abstract117)      PDF(pc) (4931KB)(92)       Save
    Taibai Mountains, located at the northern foot of the Qinling Mountains, are composed of the Yuan Taibai Mountain (also known as East Taibai Mountain), Aoshan Mountain (also known as West Taibai Mountain) and their connection part. With its complex geographical and climatic conditions, Taibai Mountains are extremely rich in wild plant resources. Based on field investigation, literature review and specimen identification, wild vascular plants resources and their diversity in Taibai Mountains were studied by the sixth Traditional Chinese Medicine (TCM) Resources Scientific Expedition Team of Shenyang Pharmaceutical University. 222 species of vascular plants belonging to 163 genera and 63 families were collected during July 2012 in this area, and most of the plants are angiosperms. The families with more species are Liliaceae, Ranunculaceae, Asteraceae, Rosaceae, and Saxifragaceae, and the dominant genus are Aconitum, Sedum, Eleutherococcus, Pedicularis, Polygonatum, and Patrinia. In terms of life form, perennial herbs are the main species, accounting for 72.97% of the total species, with others being some annual (or biennial) herbs, shrubs and lianas. Among all the collected vascular plants, 170 species of them are medicinal vascular plants, accounting for 76.58% of the total. Most of the medicinal parts are roots and rhizomes, followed by the whole plants. Finally, on the basis of investigation and study, some suggestions are put forward to strengthen the protection and utilization of plant resources in Taibai Mountains.
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    Analysis of vascular plant resources and diversity in Machin County, Qinghai Province
    Hu Chen, Dongdong Wang, Qing Wang, Anhua Wang, Jingming Jia
    Asian Journal of Traditional Medicines    2023, 18 (6): 271-279.  
    Abstract91)      PDF(pc) (1240KB)(98)       Save
    Machin County is situated in the Sanjiangyuan Nature Reserve in the southeastern part of Qinghai Province. Influenced by the special topography and climate of the Qinghai-Tibet Plateau, Machin County has complex and diverse plant species. The vascular plant resources and diversity in Machin County were studied through field survey, literature review and specimen identification. The results show that there are 47 families and 127 genera and 256 species of vascular plants in the region, basically angiosperms, including those containing more species of the family Asteraceae, Buttercup, Genus Ginseng, Leguminosae and Rosaceae, and those containing more species of the genus Artemisia, Artemisia, Aster and Donzonia. In terms of life type, perennial herbs are the most dominant ones, accounting for 77.34% of the total number of species, followed by some annual (or biennial) herbs and shrub types. There are 191 species of medicinal vascular plants, accounting for 74.61% of the total number of species, including 48 species of Tibetan medicine. In terms of the medicinal parts of these plants, whole herb category is the most common one, followed by the root and rhizome category. Based on the investigation and research, we have proposed the conservation and utilization of plant resources in Machin County, Qinghai Province.
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    Chemical composition and biological activities of volatile oil isolated from Curcumae rhizoma
    Wenhan Wang, Yibo Wang, Yuntian Xing, Xinyao Wang, Guanyi Zhao, Yu Chen
    Asian Journal of Traditional Medicines    2023, 18 (6): 280-288.  
    Abstract110)      PDF(pc) (1008KB)(88)       Save
    Curcumae rhizoma (C. rhizoma), the rhizome of Curcuma Longa L., Curcuma kwangsiensis L. and Curcuma wenyujin L. in the ginger family, is a treasure in traditional Chinese medicine. It has the effect of promoting qi and breaking blood, eliminating accumulation and relieving pain. With the development of modern medicine, the active ingredients and therapeutic mechanism of C. rhizoma have been gradually revealed. In this paper, the chemical composition and biological activities of volatile oil isolated from C. rhizoma are reviewed in detail, aiming to provide reference for further utilization of C. rhizoma volatile oil and provide more effective drug options for clinical treatment.

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    Computational investigation on the molecular structure and chemical reactivity of a traditional Chinese medicine extract MK-1 molecule
    Jian Zhang
    Asian Journal of Traditional Medicines    2023, 18 (5): 209-217.  
    Abstract113)      PDF(pc) (2925KB)(150)       Save
    MK-1 molecule (C 16 H 16 O 2 ), the simplest structure of vitamin K (VK) compound family, is an extract from traditional Chinese medicine Cymbopogon distans (Nees ex Steud.) Wats (Chinese name YunXiangCao), which has attracted a great deal of attention in recent years due to its antiasthmatic, antitussives and expectorant effects. To investigate the molecular structure and chemical reactivity of MK-1 molecule, computational investigations on six conformational minima structures were carried out at the MP2/6-311++G(2d,2p) level of theory. Several local reactivity descriptors including condensed Fukui function, average local ionization energy, and molecular electrostatic potential on each individual atom were determined to predict the intrinsic reactivity of MK-1 molecule.
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    Research progress on chemical constituents and pharmacological effects of medicinal plant Gynostemma pentaphyllum
    Yibo Wang, Yi’an Shi, Guanyi Zhao, Shuo Wang, Ying Li, Yu Chen
    Asian Journal of Traditional Medicines    2023, 18 (5): 218-235.  
    Abstract119)      PDF(pc) (4538KB)(188)       Save

    Gynostemma pentaphyllum (G. pentaphyllum) is a traditional medicinal plant with medicinal and economic value. With in-depth research on the chemical compositions and pharmacological effects, the applications of G. pentaphyllum have been expanded. G. pentaphyllum has the effects of clearing heat and detoxification, relieving cough and phlegm, nourishing heart, tranquilizing nerves, and can be used to treat gastroenteritis, tracheitis, pharyngitis, hyperlipidemia, and arteriosclerosis. It can also be used to alleviate symptoms such as migraines, insufficient sleep, and white hair. In recent years, G. pentaphyllum has also been used for clinical adjuvant treatment of various cancers. In this study, the chemical constituents and pharmacological effects on G. pentaphyllum in recent years were reviewed. This review could provide reference for further development and utilization of G. pentaphyllum.

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    Investigation on vascular plant resources and their diversity in Wuzhishan, China
    Peiying Chen, Minli Ruan, Anhua Wang, Jingming Jia
    Asian Journal of Traditional Medicines    2023, 18 (5): 236-245.  
    Abstract118)      PDF(pc) (1278KB)(132)       Save
    Wuzhishan, located in the central part of Hainan Island and characterized by undulating terrain and diverse vegetation, is rich in plants. In October 2020, field investigations were carried out by the 14th Shenyang Pharmaceutical University Chinese Medicine Resources Scientific Expedition Team. Through specimen collection and literature retrieval, the team collected and analyzed vascular plants, resulting in the identification of 455 species belonging to 328 genera in 145 families. The dominant families are Leguminosae, Malvaceae, Compositae, Rubiaceae, Lauraceae, Pteridaceae, and Polypodiaceae. The main dominant species were perennial herb, comprising 147 species, 32.31% of the total. From the 367 species of medicinal vascular plants, the team screened and recorded 20 species of Li medicine according to indications of the medicinal use and the part of the plant used. As a result, the dominant families of vascular plants were similar to medicinal vascular plants, which means vascular plants is an important medicinal resource in Wuzhishan. Based on the investigation and research, further suggestions were made to strengthen the conservation and utilization of plant resources in Wuzhishan.
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    Evaluation of the effect of shodhana (detoxification) process using chromatographic profiling (HPTLC, HPLC, LC-MS, and GC-MS) and estimation of the content of toxic colchicine in Gloriosa superba Linn. tubers
    Ajay Kumar Meena, Poorna Venktaraman, Mohit Motiwale, Ravindra Singh, Kusuma Ganji, N. Srikanth, K. S. Dhiman
    Asian Journal of Traditional Medicines    2023, 18 (4): 143-162.  
    Abstract188)      PDF(pc) (6977KB)(147)       Save
    Shodhana (purification/detoxification) is an important aspect of Ayurveda. It has been described in several important pieces of literature. In this study, we performed shodhana process on Langali (Gloriosa superba Linn.) tubers of family Liliaceae, a semi-woody herbaceous climber with significant therapeutic properties. We compared the unprocessed (before purification) and processed (after purification) samples based on the phytochemical, physicochemical, and chromatographic study, including HPTLC, HPLC, GC-MS and LC-MS. Significant changes were observed in profiling after the shodhana process. This plant contains colchicine, known for its toxic effects, particularly cardiotoxicity. Therefore, we quantified colchicine in the unprocessed and processed samples of Gloriosa superba Linn. tubers using HPLC method. Results showed that the percentage of colchicine was reduced by 13.67% in chloroform extract and 20.97% in ethanol extracts after the shodhana process.
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    Application of Caenorhabditis elegans in screening active ingredients of traditional Chinese medicine
    Ling Zhao, Mengyue Zhang, Yingying Wu, Rutian Jin, Lingxuan Li, Ying Long, Xin Wu
    Asian Journal of Traditional Medicines    2023, 18 (4): 163-172.  
    Abstract210)      PDF(pc) (1898KB)(662)       Save
    People continue to recognize the important role of Chinese medicine in the treatment of diseases, and there is an urgent need to clarify the mechanism of Chinese medicine. Because of the multi-target and multi-component characteristics of traditional Chinese medicine, it is difficult to elaborate from a single perspective. As a high-quality animal model, Caenorhabditis elegans with the characteristics of small size and fast reproduction, has been widely used in traditional Chinese medicine activity experiments. In this article, Caenorhabditis elegans, as model organisms used to screen the active components of traditional Chinese medicine were reviewed.
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    Chemical composition and biological activities of Portulaca oleracea
    Haonan Yu, Yi’an Shi, Yibo Wang, Yunpeng Yang, Ying Li, Yu Chen
    Asian Journal of Traditional Medicines    2023, 18 (4): 173-202.  
    Abstract225)      PDF(pc) (1051KB)(258)       Save
    Portulaca oleracea (P. oleracea) is a traditional Chinese herbal that has the effects of soothing the liver and clearing collaterals, strengthening the spleen and stomach, moistening the intestines and detoxifying. With the development of the pharmaceutical industry, the medicinal value of P. oleracea is becoming increasingly prominent. It is commonly used in clinical practice for clearing heat and detoxifying, inhibiting bacteria, preventing and treating diseases such as hypertension, coronary heart disease, and cerebral infarction, indicating its broad application prospects. This study reviews the chemical components and pharmacological activities of P. oleracea in recent decades.
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    Mechanism of Cinnamomum camphora essential oil for analgesia based on gas chromatography-mass spectrometry integrated network pharmacology
    Nianyun Yang
    Asian Journal of Traditional Medicines    2023, 18 (3): 87-97.  
    Abstract432)      PDF(pc) (4328KB)(240)       Save
    This study aims to explore the analgesic ingredients and mechanism of Cinnamomum camphora essential oil (CCEO). The constituents in CCEO were characterized qualitatively by gas chromatography-mass spectrometry. Targets related to active ingredients were collected by PubChem and Swiss Target Prediction. Targets related to pain were screened by TTD and OMIM database, and compound-target network was established by Cytoscape software. Gene ontology (GO) function and Kyoto encyclopedia of genes and genomes (KEGG) pathway enrichment analysis of targets were carried out by DAVID database. Protein-protein interaction (PPI) network was established and analyzed by STRING database. Molecular docking method was used to verify the interaction between main components and relevant core targets. A total of 13 compounds were identified in CCEO, and 58 related targets were predicted. GO function enrichment analysis revealed that the selected targets were mainly involved in biological processes such as chemical synaptic transmission and molecular function such as neurotransmitter receptor activity; 24 signal pathways were screened by KEGG pathway enrichment analysis, including neuroactive ligand-receptor interaction, retrograde endocannabinoid signaling and calcium signaling pathway. Docking results showed that the main constituents had certain affinities with the key targets. The active ingredients in CCEO regulated multiple signaling pathways to ameliorate pain through AR, ACHE, ESR1, GABRG2, PTGS2 and PPARγ.
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    The main chemical constituents from Piper amalago: A review of its phytochemistry
    Zhaojun Zhang, Zhikang Duan, Xiaoxiao Huang
    Asian Journal of Traditional Medicines    2023, 18 (3): 98-115.  
    Abstract299)      PDF(pc) (1591KB)(201)       Save
    Piper amalago (P. amalago) is a traditional medicine in Brazil for the treatment of leishmanial. Owing to its rare occurrence and potent pharmacological activities, efforts have been devoted to the identification of its diverse constituents, especially terpenoids. Researchers have found that the major constituents of P. amalago were amides, monoterpenes, norisoprenoids, sesquiterpenes, aliphatic hydrocarbons and aromatic hydrocarbons. The amides show anxiolytic, anti-inflammatory, antileishmanial and antinociceptive activity. This review summarizes the research progress of the structural diversity and pharmacological activities of P. amalago.
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    Chemical constituents and biological activities of Artemisiae argyi
    Zhinan Leng, Yi’an Shi, Shuo Wang, Yunpeng Yang, Ji Wu, Yu Chen
    Asian Journal of Traditional Medicines    2023, 18 (3): 116-136.  
    Abstract358)      PDF(pc) (1172KB)(243)       Save
    Artemisiae argyi (A. argyi) is a traditional medical plant, with medicinal and economic value. It has been used to treat diseases for more than 2000 years, and its application has been expanded in recent years with the in-depth research on the chemical composition and pharmacology. It is mainly used clinically for the treatment of “cold pain in the abdomen, cold clotting in the menstrual channels, cold infertility in the uterus, fetal movement, vomiting blood, epistaxis, pus and blood dysentery, and external treatment of itchy skin” and other symptoms. This paper reviews the research on the biological activity and chemical composition of A. argyi by scholars in recent decades.
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    Predicting ADME/Tox properties of hydroxytyrosol in the leaves of Olea europaea L.
    Suzhen Jiang, Xinghua Liu, Hongjian Yu, Shihong Li, Jingming Jia, Anhua Wang
    Asian Journal of Traditional Medicines    2023, 18 (2): 45-53.  
    Abstract251)      PDF(pc) (1823KB)(222)       Save
    In order to study the possibility of hydroxytyrosol (HT) as a drug, we used SwissADME system to predict ADME of HT and pkCSM system to predict Tox of HT. The results show that hydroxytyrosol meets the Lipinski’s five principles of drug-like properties. With strong efficacy and pharmacological activity, HT has high drug-likeness degree. With good bioavailability, it can be easily absorbed by the gastrointestinal tract, though not absorbed by skin. Hydroxytyrosol has not only a strong potency and pharmacological activity, but also no liver toxicity and skin allergy. Tox data predicts that it has mutagenic potential, which may be the result of overreduction.
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    Study on the pharmacological activities and chemical structures of Viburnum dilatatum
    Zhiheng Gao, Yufei Xi, Man Wang, Xiaoxiao Huang, Shaojiang Song
    Asian Journal of Traditional Medicines    2023, 18 (2): 54-59.  
    Abstract190)      PDF(pc) (3063KB)(124)       Save
    Viburnum dilatatum (jiami in Chinese), belonging to the Caprifollaceae family, is widely distributed in Japan and China. Phytochemical investigations of Viburnum dilatatum (V. dilatatum) have resulted in the isolation of triterpenoids, phenolic glycosides essential oil, norisoprenoids, etc. Research results have shown that the chemical constituents of V. dilatatum possess various pharmacological activities, including antihyperglycemic, antioxidant activity and antiulcer effects. This study reviewed the chemical constituents and pharmacological activities of V. dilatatum to provide practical and useful information for further research and development of this plant.
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    Chemical compositions and biological activities of Flos lonicerae
    Yi’an Shi, Luming Pan, Luyan Yang, Jing Sun, Meng Zhang, Yu Chen
    Asian Journal of Traditional Medicines    2023, 18 (2): 60-68.  
    Abstract195)      PDF(pc) (906KB)(117)       Save
    Flos lonicerae is the dry flower bud of Lonicera japonica Thunb, and it is a very important Chinese herbal medicine in China. In ancient times, it was widely used to treat the exopathogenic wind-heat, epidemic febrile diseases, sores, carbuncles and some infectious diseases. Modern pharmacological research has indicated that it has anti-inflammatory, anti-bacterial, anti-viral and anti-oxidation activities. This paper reviews the chemical compositions and biological activities of Flos lonicerae in order to provide reference for its application in clinical practice in the future.
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    Chemical constituents and pharmacological activities of Salvia miltiorrhiza
    Man Wang, Jingxian Ren, Zhuoyang Cheng, Xiaoxiao Huang
    Asian Journal of Traditional Medicines    2023, 18 (2): 69-80.  
    Abstract215)      PDF(pc) (1305KB)(184)       Save
    Salvia miltiorrhiza Bunge (S. miltiorrhiza), a perennial plant of the genus Salvia, is widely used in traditional folklore medicine. Previous chemical research on this plant contains diterpenoid quinones, phenolic acids, polysaccharides and other compounds. The pharmacological investigation of S. miltiorrhiza has shown that it has various pharmacological activities, such as cardiovascular system protection, anti-inflammatory, anti-oxidant, anti-tumor, liver protection, and neuroprotection activities. This research tends to give an overview of the main chemical constituents and pharmacological effects of S. miltiorrhiza, aiming to reveal its potential value and provide reference for its further development.
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    Molecular mechanism study of Radix Pueraria for the treatment of glioma based on network pharmacology
    Li Ye, Jiaoyang Hou, Guodong Yao
    Asian Journal of Traditional Medicines    2023, 18 (1): 1-14.  
    Abstract235)      PDF(pc) (5717KB)(242)       Save
    Radix Pueraria (RP) has a long history of dual-use in medicine and food, and is well known as “Asian ginseng”. Recently, some studies about the effect of RP against glioma have been reported. However, little is elucidated about the molecular mechanism of interaction. This study used network pharmacology and molecular docking techniques to clarify the molecular mechanism of RP in the treatment of glioma. Traditional Chinese Medicine Systems Pharmacology Database and Analysis Platform (TCMSP) was applied to screen potential active ingredients of RP and their targets. Targets for glioma were obtained from Genecards, OMIM, and Therapeutic Target Database (TTD). The topological analysis of cross-target and core target interaction was conducted using protein-protein interaction analysis (PPI). With the application of bioinformatics, GO and KEGG enrichment analyses were further carried out. Molecular docking was used then to validate the binding affinity between active components and key targets. This study successfully identified 6 potential active ingredients, namely beta-sitosterol, daidzein, formononetin, genistein, ononin, and puerarin. The hub targets were AKT1, TP53, VEGRA, EGFR, and MAPK3. These targets were mainly involved in biological processes, such as RNA polymerase II-specific DNA-binding transcription factor binding, and positive regulation of cell migration in the membrane raft, and were regulated by PI3K-Akt pathway. Further study showed that almost all the compounds had good binding abilities with above-mentioned targets. In short, this study systematically revealed the anti-glioma mechanism of RP to provide reference for the treatment of glioma.
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