Asian Journal
Of Traditional Medicines

Abstract: 2-Oxoglutarate (2OG)-dependent dioxygenases (2-ODDs) are omnipresent iron-containing non-heme enzymes that catalyze various oxidation-reduction reactions in plant growth and development, nucleic acid modification and secondary metabolism. We systematically summarized recent research on the oxidative modifications of plant 2-ODDs and related enzymes, their vital importance in the biosynthesis of plant special metabolites, and their catalytic specificity/flexibility, and discussed the potential of 2-ODD as a new approach for the identification of pivotal genes and the elucidation of biosynthetic pathway.

Key words: 2-oxoglutarate-dependent dioxygenase, secondary metabolism, flavonoid, terpenoid, biosynthesis