Isolation, structure elucidation and antioxidant activity of natural 
products from the root bark of Ailanthus altissima (Mill.) Swingle

Asian Journal of Traditional Medicines ›› 2020, Vol. 15 ›› Issue (5): 217-227.

Isolation, structure elucidation and antioxidant activity of natural products from the root bark of Ailanthus altissima (Mill.) Swingle

Ye Chang, Yuxi Wang, Xiaoxiao Huang*, Shaojiang Song*

Key Laboratory of Computational Chemistry-Based Natural Antitumor Drug Research & Development, Liaoning Province, School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, China

Received:2020-02-06 Revised:2020-06-30 Accepted:2020-06-30 Online:2020-10-20 Published:2020-10-30
Contact: School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, 103 Wenhua Rd., Shenyang 110016, China; Tel.:024-43520793; E-mail: xiaoxiao270@163.com (Xiaoxiao Huang); songsj99@163.com (Shaojiang Song). E-mail:xiaoxiao270@163.com;songsj99@163.com

Abstract

Abstract: Eight compounds (1-8) were isolated from Ailanthus altissima (Mill.) Swingle, including four lignans, three phenylpropanoids and a simple aromatic compound, their structures were identified by nuclear magnetic resonance spectra and mass spectrometry data. Among them, compounds 1, 3, 5 and 8 were first obtained from this genus. In addition, free radical scavenging ability of compounds 1-8 were evaluated using DPPH, ABTS, and FRAP assays and the results showed that compound 2 exhibited potent antioxidant activity in DPPH and ABTS radical scavenging assays and compound 7 showed the highest value of FRAP radical scavenging.

Key words: Ailanthus altissima (Mill.) Swingle, reactive oxygen species (ROS), free radical, antioxidant

Ye Chang, Yuxi Wang, Xiaoxiao Huang, Shaojiang Song. Isolation, structure elucidation and antioxidant activity of natural products from the root bark of Ailanthus altissima (Mill.) Swingle[J]. Asian Journal of Traditional Medicines, 2020, 15(5): 217-227.

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