Asian Journal
Of Traditional Medicines

Abstract: Parkinson’s disease (PD), as a common neurodegenerative disorder, has brought a heavy economic burden to healthcare system around the world. However, currently there is still lack of effective treatment for PD patients. In this study, we used a docking weighted network pharmacological approach to understand the therapeutic potentiality of C. pinnatifda against PD. Six compounds, namely huangnin A (SMO-13), leptolepisol D (SMO-12), 7',8'-threo-7R,8R-1-[4-[(2-hydroxy-2-(4-hydroxyl-3- methoxyphenyl)-1-(hydroxymethyl)ethoxy]-3-methoxyphenyl]-1,2,3-propanetriol (SMO-4), huangnin B (SMO-14), Crataegusnin A (SMO-1) and erythro-(7S,8R)-guaiacyl-glycerol-β-O-4'-dihydroconiferyl ether (SMO-26) were predicted to have potential binding therapeutics for PD target proteins, and Myeloperoxidase (5mfa), Alpha-synuclein (3q27), 5-hydroxytryptamine receptor 1B (4iar) and Glycogen synthase kinase-3 beta (1o6l) were found to be the most potential target proteins in terms of docking weighted network pharmacological analysis. We expect that our approach using docking weighted network pharmacological could be applied to predict the pharmacological effectiveness of C. pinnatifda against PD.

Key words: Parkinson’s disease, Crataegus pinnatifda, network pharmacology