Asian Journal
Of Traditional Medicines

Abstract: Six oleanolic acid saponins were isolated from Monoammonium glycyrrhinate (MAG). Their structures were elucidated via spectroscopic data analyses, including 13C NMR and HRESIMS. The assay concerning the inhibition of NO inhibition induced by lipopolysaccharide in RAW 264.7 cells was conducted to evaluate their anti-inflammatory activity of the isolated triterpenoid saponins. The results revealed that compound 4 exhibited weak inhibitory activity on the production of NO with the inhibition rate 12.04% at 100 μM compared with the positive control drug, minocycline, the inhibition rate of which was 35.39% at 100 μM.

Key words: Licorice, Monoammonium glycyrrhinate, oleanolic acid saponins, NO inhibition, anti-inflammatory