Asian Journal
Of Traditional Medicines

Abstract: The present investigation is aimed to determine the optimal formulation and preparation technology of Mailiu tablet, which
is composed of Crataegi Fructus, Notoginseng Radix et Rhizoma and Ginkgo Folium. The optimal extraction of one of the
ingredients Crataegi Fructus extract (CFE) was performed by the total flavonoid content verifying. The optimal formulation and
preparation technology was determined as following: weight the CFE, NRE and GBE 200 g totally in proportion respectively,
mixed uniformly after adding corn starch 23 g and dextrin 11 g, prepared wet granules through stainless steel sieve of 16 meshes,
and dried the wet granules at 50°C. Then the dry granules were passed through 20 mesh screen and added CMS-Na 15 g and
magnesium stearate 1 g uniformly, followed by compressing into 1000 tablets with a single punch tablet press and coating in
opadry. The preparation technology was proved to be reasonable, feasible and stable according to the weight variation and
disintegrating time.

Key words: Mailiu tablet, hyperlipidemia, preparation technology, disintegrating time