Protective effect of the roots of Capparis sepiaria Linn. (Himsra) on carbon tetrachloride-induced hepatotoxicity

›› 2012, Vol. 7 ›› Issue (1): 18-28.

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Protective effect of the roots of Capparis sepiaria Linn. (Himsra) on carbon tetrachloride-induced hepatotoxicity

Varadharajan Madhavan ¹; Anita Murali ²*; Sunkam Yoganarsimhan ¹; Ajay Shankar Pandey ¹

1. Department of Pharmacognosy, M S Ramaiah College of Pharmacy, Bangalore 560054, India2. Department of Pharmacology, M S Ramaiah College of Pharmacy, Bangalore 560054, India

Received:2011-06-24 Revised:2012-01-01 Online:2012-02-20 Published:2012-02-20
Contact: Anita Murali

Abstract

Abstract: Capparis sepiaria L. is an important drug used in Ayurvedic medicine. In the present study extracts of the roots of C. sepiaria were evaluated for their hepatoprotective potential on carbon tetrachloride (CCl₄)-induced hepatotoxicity in albino Wistar rats. The extent of hepatoprotection was evaluated by estimating the serum levels of hepatic transaminases (SGPT and SGOT), alkaline phosphatase (ALP), total protein (TP), and bilirubin (total and direct). Aqueous and ethanol extracts significantly reduced the increased liver weight as well as the serum levels of SGPT, SGOT, ALP, and bilirubin and normalized the reduced serum protein levels in the treated rats as supported by histopathological studies. The extracts were also subjected to preliminary organic analysis and chromatographic studies including an HPTLC finger print profile. The results obtained indicate that the roots of C. sepiaria have a significant hepatoprotective effect on CCl₄-induced hepatotoxicity.

Key words: Capparis sepiaria, carbontetrachloride induced hepatotoxicity, histopathology, roots, HPTLC

Varadharajan Madhavan;Anita Murali *;Sunkam Yoganarsimhan;Ajay Shankar Pandey . Protective effect of the roots of Capparis sepiaria Linn. (Himsra) on carbon tetrachloride-induced hepatotoxicity[J]. , 2012, 7(1): 18-28.

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Protective effect of the roots of Capparis sepiaria Linn. (Himsra) on carbon tetrachloride-induced hepatotoxicity

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Asian Journal Of Traditional Medicines

Protective effect of the roots of Capparis sepiaria Linn. (Himsra) on carbon tetrachloride-induced hepatotoxicity

Knowledge

Abstract

Cite this article

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Related Articles 15

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Asian Journal
Of Traditional Medicines