›› 2009, Vol. 4 ›› Issue (1): 7-13.
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Yi-nan Chen; Liang Wang; Jie Ren; Yanqiu Liu;Song You *
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Abstract: Spirostanol glycosides (SGs) are natural products that exhibit antifungal, antirheumatic and cytotoxic properties. Biotransformation studies showed that furostanol glycosides (FGs) can be transformed to SGs, a process which is catalyzed by recombinant F-26-O-β-glucosidase (F26G) in vitro. The selectivity of F26G depends on the structures of the substrates. The transformation mechanism involves the hydrolysis of glucose at C-26 and the cyclization of the F ring.
Key words: spirostanol glycosides, furostanol glycosides, biotransformation, F26G, selectivity
Yi-nan Chen;Liang Wang;Jie Ren;Yanqiu Liu;Song You * . The selective biotransformation of furostanol glycosides and their analogs by recombined F-26-O-β-glucosidase [J]. , 2009, 4(1): 7-13.
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