Asian Journal
Of Traditional Medicines

Abstract: To observe the protective effect of ginsenoside Re against cerebral ischemia, mice were subjected to bilateral carotid artery and cranial
nerve ligation, and the cerebral index, the cerebral water content , the activities of cerebral SOD and the content of cerebral MDA were
determined at the same time. Hypoglucose and hypoxia injury models were used to determine the protective effect of ginsenoside Re on PC12
cells. Following pretreatment with ginsenoside Re ( 8，16，32 mg·kg-1 ) for 10 days in mice, the cerebral index, the cerebral water content
and cerebral MDA content were significantly reduced, and the activity of cerebral SOD was improved compared with the controls; the cell
survival rate was significantly improved and the LDH activity was markedly reduced with ginsenoside Re(10-8，10-7，10-6，10-5 mol·L-1 ) for
18 h in PC12 cells.

Key words: ginsenoside Re, SOD, MDA, PC12 cells, hypoglucose, hypoxia