Asian Journal
Of Traditional Medicines

Tuberculosis, an infectious disease, causes considerable morbidity and mortality. Within the host immune system, transition  metals play vital roles in combating Mycobacterium tuberculosis (MTB), acting as catalytic cofactors, mediating electron  transport, and catalyzing antimicrobial radical formation. Both the host and MTB have developed mechanisms to maintain  metal homeostasis. Flavonoids, important herbal materials with potent iron-chelating ability, have gained attention for their  antitubercular and anti-inflammatory effects, making them a promising treatment option. This review explores how trace  metals restrict MTB and the dynamic balance between pathogen and host, revealing innovative perspectives for therapeutic  interventions.