Asian Journal
Of Traditional Medicines

Thrombosis is a leading cause of mortality and morbidity in patients suffering from polycythemia vera (PV). Drug pair Salviae  Miltiorrhizae Radix et Rhizoma (Danshen, DS) and Notoginseng Radix et Rhizoma (Sanqi, SQ) is common traditional Chinese  medicine (TCM) used in clinical practice to promote blood circulation and eliminate blood stasis. In this study, network  pharmacology and molecular docking were used to analyze the potentially active ingredients and underlying mechanisms of drug  pair DS-SQ against thrombosis after PV. These results show that 54 targets are related to both disease and the drug pair. Nineteen  core targets, including IL-6 and AKT1, were screened. Luteolin and tanshinone IIa from DS as well as quercetin from SQ might  be the major substances in the treatment of thrombosis after PV. KEGG enrichment analysis demonstrated that the lipid and  atherosclerosis signaling pathway might play a significant role. These results provide valuable insights and a reference for the use of  drug pair DS-SQ in management of thrombosis after PV and lay a foundation for further exploration of pharmacological effects.

"> thrombosis, polycythemia vera, Salviae Miltiorrhizae Radix et Rhizoma, Notoginseng Radix et Rhizoma, network  , pharmacology, mechanism