亚洲传统医药

本期目录

2026年, 第21卷, 第3期　刊出日期：2026-09-30 上一期   

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Study and application of exosomes combined with Traditional Chinese Medicine in the treatment of diabetic-related diseases Hanyi Li, Chenxi Yin, Shiqi Tan, Dongsheng Zong, Yuting Li 2026 (3):  179-194.  摘要 ( 34 )   PDF(2009KB) ( 48 )   Exosomes are nanosized extracellular vesicles (30–150 nm) secreted by almost all cells, mediating intercellular communication by  delivering bioactive molecules such as proteins, nucleic acids, and lipids. In diabetic complications, they act as a “double-edged  sword”: pathologically, they propagate damaging signals that exacerbate disease progression, whereas therapeutic exosomes from specific sources exert multi-targeted therapeutic effects. Traditional Chinese Medicine (TCM), characterized by unique  holistic regulation, can modulate the secretion and cargo composition of exosomes in vivo, thereby offering a novel synergistic  strategy for the treatment of diabetic complications. This paper reviews the latest research progress on exosomes and exosome-TCM combination strategies in five diabetic complications, including diabetic nephropathy, diabetic encephalopathy, diabetes  complicated with cerebral infarction, diabetic wound healing, and diabetic retinopathy. This review analyzes their cell source  specificity and TCM-regulated mechanisms. It also discusses the potential of exosomes as early diagnostic biomarkers and as  engineered TCM-related delivery platforms. Current exosome research still faces challenges, such as heterogeneity control,  large-scale preparation, and clinical supervision. However, emerging technologies including genetic modification and artificial intelligence combined with personalized TCM regulation strategies are accelerating their clinical translation, providing a  systemic reference for the integrated research and clinical development of exosome-TCM in the field of diabetic complications. 相关文章 | 计量指标

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Applications of traditional Chinese medicine fermentation technology in clinical treatment Zixuan Che, Yao Zhao, Ran Guo, Jiankun Jin, Meng Zhang, Ying Li, Yu Chen 2026 (3):  195-205.  摘要 ( 27 )   PDF(1647KB) ( 11 )   Traditional Chinese medicine fermentation technology is rooted in ancient fermentation techniques and has been innovated  and developed by incorporating modern biotechnology. In recent years, this technology has shown broad application potential in clinical treatment. The article summarizes the application of fermented traditional Chinese medicine targets specific disease models in tumors, metabolic diseases and neurological disorders. It also analyzes the connection between fermented medicine and diseases through network pharmacology and clinical data. The possibility of personalized fermented traditional Chinese  medicine is discussed. 相关文章 | 计量指标

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The effects of bioactive natural products from Chinese medicinal herbs and compound prescriptions on type 2 diabetes: a review Yizhen Chen, Ruilin Sun, Yunkun Zhang, Lerong Li, Ruizi Ma, Shuhua Yang, Xin Wu 2026 (3):  206-230.  摘要 ( 29 )   PDF(29323KB) ( 24 )   Type 2 diabetes mellitus (T2DM) is a globally prevalent metabolic disease with a relatively high incidence rate in Asia. Its pathological mechanism involves multiple factors such as insulin resistance, β-cell dysfunction and disorders of glycolipid metabolism. In recent  years, Traditional Chinese Medicine (TCM) treatment has gradually become a research hotspot in T2DM due to its multi-target and multi-pathway synergistic mechanism. Compared with single-target chemical drugs such as metformin have a single target, multi-target and multi-pathway traditional Chinese medicine treatment has gradually shown unique advantages in the treatment of T2DM. This review summarizes the mechanisms of bioactive natural products present in Chinese medicinal herbs, including polysaccharides, flavonoids, alkaloids, terpenoids, and saponins, in the treatment of T2DM. These compounds are discussed as natural products or  phytochemicals associated with medicinal plants used in Chinese materia medica. In addition, representative traditional compound  prescriptions are further summarized from the perspective of multi-component and multi-target regulation. Furthermore, we adopted  the method of network toxicology and conducted relevant toxicity analysis taking Compound Liuwei Dihuang Pills as an example, suggesting that the toxicity of traditional Chinese medicine in the treatment of type II diabetes needs to be predicted in advance to avoid toxicity risks. 相关文章 | 计量指标

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Research progress on the antitumor activity and mechanisms of licochalcone Manxin Cao, Yujiao Liu, Sirui Wang, Zhishuo Tian, Zihao Qiu, Wei Tian 2026 (3):  231-243.  摘要 ( 23 )   Licochalcones are important active components derived from the traditional Chinese medicinal herb Glycyrrhiza. Numerous studies have demonstrated that these compounds exert pharmacological effects on tumor cells. This review mainly elaborates on the classification of licochalcones and their corresponding anti-tumor activities, and summarizes the major anti-tumor  mechanisms and key signaling pathways. It intuitively clarifies the effective pathways by which these compounds interfere with  the proliferation of tumor cells, and discusses the existing limitations in current research on licochalcones. The study aims to provide a solid theoretical basis for the development of highly efficient anti-tumor drugs. 相关文章 | 计量指标

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Review on the mechanism of regulating menstruation disorder by four components of Siwu decoction Zhenyu Liu, Wanyue Zhang, Zixuan Che, Ying Li, Meng Zhang, Yu Chen 2026 (3):  244-250.  摘要 ( 36 )   PDF(3499KB) ( 14 )   Irregular menstruation is a common gynecological problem that plagues many women, impacting not only the physical  health of women, but also their mental health and overall quality of life. While modern medicine offers various treatment options for irregular menstruation, their efficacy can be suboptimal in certain cases. In contrast, traditional Chinese medicine  provides distinct therapeutic advantages. Siwu decoction, a classic Chinese medicine prescription composed of Angelica sinensis, Ligusticum chuanxiong, Paeoniae Radix and Rehmannia glutinosa, is widely used in clinical settings and demonstrates  remarkable efficacy in treating menstrual disorders. In this paper, the mechanism of the four components of Siwu decoction in  the treatment of irregular menstruation was in depth studied, aiming to provide a theoretical basis for further development and  reference. At the same time, it also provides new ideas and methods for the application of traditional Chinese medicine in the treatment of modern gynecological diseases, which is helpful to promote the development of modernization of traditional Chinese medicine and provide safer and more effective treatment programs for patients with irregular menstruation. 相关文章 | 计量指标

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Research progress on the antidepressant effects of active components in traditional  Chinese medicine via neuroinflammation and related mechanisms: a review Yunkun Zhang, Shuhua Yang, Yizhen Chen, Lerong Li, Ruizi Ma, Xin Wu 2026 (3):  251-274.  摘要 ( 32 )   PDF(2346KB) ( 22 )   Depression is a psychiatric disorder characterized by persistent low mood and anhedonia as core symptoms. Its global prevalence continues to rise, imposing a substantial disease burden on society. The pathological mechanisms encompass multiple facets,  including neuroinflammation, impaired neuroplasticity and hyperactivation of the hypothalamic-pituitary-adrenal (HPA)  axis, and imbalance of monoamine neurotransmitters. Active ingredients derived from traditional Chinese medicine (TCM) demonstrate unique therapeutic value in antidepressant treatmentowing to their multi-target, multi-pathway integrative  modulatory advantages. This review systematically summarizes the molecular pathways underlying the antidepressant effects  of TCM active ingredients, with a focus on neuroinflammation intervention and other related mechanisms, and outlines the mechanisms of classical antidepressant TCM formulations, providing a theoretical basis for modern research on TCM-based antidepressant therapy. 相关文章 | 计量指标