摘要：
Tuberculosis, an infectious disease, causes considerable morbidity and mortality. Within the host immune system, transition metals play vital roles in combating Mycobacterium tuberculosis (MTB), acting as catalytic cofactors, mediating electron transport, and catalyzing antimicrobial radical formation. Both the host and MTB have developed mechanisms to maintain metal homeostasis. Flavonoids, important herbal materials with potent iron-chelating ability, have gained attention for their antitubercular and anti-inflammatory effects, making them a promising treatment option. This review explores how trace metals restrict MTB and the dynamic balance between pathogen and host, revealing innovative perspectives for therapeutic interventions.
Tianyi Zhao, Qingxuan Wu, Yihao Fan, Ru Li, Zifei Yang, Wenxin Li, Xiaoyun Zhao.
From natural medicines to metal weapons: therapeutic potential of flavonoid metabolites in regulating host-Mycobacterium tuberculosis metal interactions
[J]. 亚洲传统医药, 2025, 20(3): 140-155.
Tianyi Zhao, Qingxuan Wu, Yihao Fan, Ru Li, Zifei Yang, Wenxin Li, Xiaoyun Zhao.
From natural medicines to metal weapons: therapeutic potential of flavonoid metabolites in regulating host-Mycobacterium tuberculosis metal interactions
[J]. Asian Journal of Traditional Medicines, 2025, 20(3): 140-155.
