亚洲传统医药

本期目录

2021年, 第16卷, 第5期　刊出日期：2021-10-25 上一期    下一期

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Network pharmacology-based analysis on three amicoumacin-type isocoumarin compounds from an endophytic bacterium in Houttuynia cordata Yiyao Lu, Yinjie Xiong, Mengyue Zhang, Yingying Wu, Jingjing Xu, Linyu Zhang, Xin Wu 2021 (5):  255-268.  摘要 ( 447 )   PDF(4642KB) ( 333 )   Amicoumacin isocoumarin-type compounds are mainly derived from the secondary metabolites of Bacillus bacteria, and have potential biological activities such as antibacterial, anti-tumor, anti-inflammatory, and anti-ulcer. In our previous research, three amicoumacin-type isocoumarin compounds, Paenicoumacin A, Paenicoumacin B, and Paenicoumacin C (B and C are novel), were isolated from an endophytic bacterium in Houttuynia cordata. In this study, network pharmacology and bioinformatics techniques were used to analyze the potential activities of amicoumacin compounds in the treatment of liver cancer. These compounds were found to mainly regulate cellular oxidative stress, cancer process, nucleic acid metabolism, nutritional metabolism and other pathways. The findings provide useful information for subsequent experimental verification. 相关文章 | 计量指标

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Compounds from the flowers and fruits of Abelmoschus esculentus (L.) Moench Sihui Mi, Rui Guo, Chuang Xie, Xiaoxiao Huang 2021 (5):  269-275.  摘要 ( 379 )   PDF(871KB) ( 495 )   The Abelmoschus esculentus (L.) Moench was previously reported to have various phytochemicals. Chemical fractionation yielded from the ethanolic extract of the A. esculentus ten compounds, including four alkaloids (4-6, 8) and six phenolic acids (1-3, 7, 9-10). The structures of the compounds were elucidated through extensive spectra analyses and comparison of the experimental data with reported data. It is worth mentioning that compounds 1, 2 and 5-10 were isolated from Abelmoschus esculentus (L.) for the first time. 相关文章 | 计量指标

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A network pharmacology-based study on the anti-hepatoma effect of Phellodendri Chinensis Cortex Qiulin Yan, Guodong Yao 2021 (5):  276-293.  摘要 ( 395 )   PDF(6459KB) ( 414 )   Traditional Chinese medicine (TCM) Phellodendri Chinensis Cortex (PCC) has been used for the treatment of human hepatocellular carcinoma, but the underlying mechanisms are still unclear. In this study, 15 active compositions of PCC were obtained from Traditional Chinese Medicine Systems Pharmacology Database (TCMSP), and 505 putative identified targets of PCC were screened by Swiss Target Prediction server. Next, HCC data was downloaded from Drugbank and GeneCards databases. Furtherly, 45 common targets were revealed. The network diagrams of the active component-target network, protein protein interaction (PPI) network and active component-target-pathway network were constructed using Cytoscape software. The analysis of the network results showed that the active ingredients of PCC, such as berberine, obacunone, rutaecarpine, candletoxin A, palmatine, isocorypalmine, quercetin, and (S)-Canadine, had a good binding activity with more targets. Additionally, Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analyses revealed that common targets were significantly enriched in Ras signaling pathway, ErbB signaling pathway, and Mammalian target of rapamycin (mTOR) signaling pathway. Altogether, the multi-component, multi-target, and multi-pathway characteristics of PCC provided a reference for the in-depth study of the mechanism of PCC in the treatment of HCC. 相关文章 | 计量指标

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Research progress on the main chemical constituents and pharmacological effects of Piper betle L. Zhiyong Xu, Yufei Xi, Xiaoxiao Huang, Shaojiang Song 2021 (5):  294-308.  摘要 ( 426 )   PDF(2159KB) ( 591 )   The Piper betle, belonging to Piper genus of the Piperaceae family, is an evergreen and perennial creeper used in several traditional medicines. This plant has been known to possess antioxidant, antitumor, antibacterial, anti-inflammatory and antimalarial activities. A wide range of chemical compounds including alkaloids, simple phenylpropanoids, lignans, flavonoids, steroids, triterpenoids, sesquiterpenes, monoterpenes have been isolated from this plant. The present review summarized the information concerning phytochemistry and biological activity of P. betle, providing references for the future research of this plant. 相关文章 | 计量指标

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Research progress on chemical constituents in Sophora alopecuroides L. and their pharmacological activities Bohan Yang†, Jing Wang†, Xiaoxu Gao, Jingming Jia, Anhua Wang 2021 (5):  309-322.  摘要 ( 316 )   PDF(1645KB) ( 549 )   Sophora alopecuroides L., a perennial plant belonging to Leguminosae family, is used as medicinal materials to treat a variety of skin diseases. Its chemical components are complex and diverse, mainly including alkaloids and flavonoids. Modern pharma cological studies have found that the isolated compounds from S. alopecuroides have a variety of pharmacological activities. In particular, alkaloids represented by matrine, aloperine and oxymatrine have significant anti-inflammatory, anti-viral, anti-tumor, anti-bacterial and immunomodulatory activities. This paper summarized the chemical constituents and pharmacological activities of S. alopecuroides, aiming to provide the basis for further research. 相关文章 | 计量指标