亚洲传统医药

本期目录

2021年, 第16卷, 第1期　刊出日期：2021-02-20 上一期    下一期

Regular Article

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Network pharmacology-based study on compounds from Camptotheca acuminate inhibiting liver cancer cells Jingxian Ren, Zhuoyang Cheng, Xiaoxiao Huang, Shaojiang Song 2021 (1):  1-9.  摘要 ( 470 )   PDF(2386KB) ( 500 )   Camptotheca acuminate belongs to Nyssaceae family and has been used as traditional Chinese medicine for several years. A number of compounds with anti-tumor activities have been isolated from C. acuminate. However, the targets of some compounds have not been determined. In this study, network pharmacology methods were used to analyze 74 compounds from C. acuminate and 49 target proteins of liver cancer. The results showed that the target with the largest number of directed edges was Dihydroorotate Dehydrogenase (1d3g). The compound docked with 1d3g best was AL.23 (19-O-methyangustoline). The results of this study provide further insight into the role of network pharmacology as an effective tool to illuminate the research on liver cancer. 相关文章 | 计量指标

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Study on the mechanism of Wikstroemia indica in the treatment of inflammatory diseases based on network pharmacology Jiayi Li, Zisong Bai, Tingting Guo, Heng Zhang, Gang Chen, Di Zhou, Ning Li 2021 (1):  10-23.  摘要 ( 391 )   PDF(3940KB) ( 417 )   Wiksroemia indica belongs to the family of Thymelaeaceae. As a material of Traditional Chinese Medicine, it is mainly used to treat inflammation-related diseases. However, due to its complex composition, the scientific basis for its traditional application is still insufficient and the mechanism of action is still unclear. At present, most studies on its anti-inflammatory effect focus on a certain component and its different solvent fractions. There are few reports about the synergistic mechanism of the constituents from W. indica for the treatment of inflammatory diseases. Therefore, the present study aimed to uncover its potential mechanism from a holistic perspective using the network pharmacology approach. Firstly, compounds in W. indica and genes associated with inflammatory diseases were obtained. Then, the active compounds were screened out and their targets were predicted. After that, the key targets for W. indica to treat inflammatory diseases were screened out. Finally, the protein-protein interaction (PPI), Gene ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analyses of key targets were performed to further study the mechanism of W. indica in the treatment of inflammatory diseases. The results showed that the active constituents of W. indica might play an anti-inflammatory role through the key targets CYP19A1 and CYP1B1, which clarified the primary mechanism for the treatment of inflammatory diseases and provided a scientific basis for further study of this herb. 相关文章 | 计量指标

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Isolation and identification of chemical constituents of Pithecellobium clypearia (Jack.) Benth Wanyi Shi, Yuxi Wang, Xiaoxiao Huang 2021 (1):  24-31.  摘要 ( 496 )   PDF(859KB) ( 421 )   The twigs and leaves of Pithecellobium clypearia (Jack.) Benth are used as common Chinese traditional herbal medicine to treat upper respiratory tract infection, acute gastroenteritis and bacterial dysentery. The study isolated nine compounds from the EtOAc extract, all of which were obtained from Pithecellobium Mart. for the first time. Based on 1 H-NMR and 13C-NMR data, the structures of these compounds, including two ladiosiplodins and two dihydroisocoumarins, were elucidated. 相关文章 | 计量指标

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SARS-CoV-2: structure, host, virus source and pathogenesis Mingxue Li, Yueying Yang, Yang Liu, Mengzhu Zheng, Dejuan Sun, Hua Li, Lixia Chen 2021 (1):  32-52.  摘要 ( 566 )   PDF(859KB) ( 526 )   Cancer is a serious threat to human life and a big problem in clinical treatment. Some natural active substances extracted from Traditional Chinese Medicine can effectively inhibit the growth of cancer cells, which is a new direction for finding more effective anticancer drugs. Osthole is a natural coumarin compound extracted from Traditional Chinese Medicines such as Cnidium monnieri, Angelica pubescens and Peucedanum praeruptorum Dunn. It has significant inhibitory activity against a variety of cancers. This paper summarizes the anticancer effects and molecular mechanisms of osthole in the treatment of cancers in recent years in order to provide references for further research. 相关文章 | 计量指标

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Research progress on anticancer effects and molecular mechanisms of osthole Jiayi Bi, Zixuan Gao, Guogang Zhang, Yu Chen 2021 (1):  53-62.  摘要 ( 494 )   PDF(970KB) ( 351 )   Cancer is a serious threat to human life and a big problem in clinical treatment. Some natural active substances extracted from Traditional Chinese Medicine can effectively inhibit the growth of cancer cells, which is a new direction for finding more effective anticancer drugs. Osthole is a natural coumarin compound extracted from Traditional Chinese Medicines such as Cnidium monnieri, Angelica pubescens and Peucedanum praeruptorum Dunn. It has significant inhibitory activity against a variety of cancers. This paper summarizes the anticancer effects and molecular mechanisms of osthole in the treatment of cancers in recent years in order to provide references for further research. 相关文章 | 计量指标