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本期目录

    2024年, 第19卷, 第6期 刊出日期:2024-12-30 上一期    下一期
    Quantitative analysis of Cefpodoxime Proxetil raw material and dry suspension using proton nuclear magnetic resonance
    Yufei Liu, Bin Li, Xinyu Tao, Dongyang Zhao, Xinyu Zhang, Yan Wu, Wenyi He, Chenggen Zhu, Xiangju Jin, Hongyue Liu, Xin Di, Ye Tian, Yanan Wang
    2024 (6):  305-320. 
    摘要 ( 58 )   PDF(4367KB) ( 43 )  
    This study established a simple, rapid, and accurate nuclear magnetic resonance (NMR) quantitative method to determine the cefpodoxime proxetil content in raw materials and dry suspensions, and evaluated the uncertainty. The relative content of cefpodoxime proxetil iso-A and iso-B was also analyzed based on 1 H NMR. In this study, an internal standard method was used, with DMSO-d 6 as the solvent and maleic acid and 1,3,5-trimethylbenzene as internal standards, to calculate the concentration of the samples. Quantitative analysis was performed using both the traditional quantitative NMR (traditional qNMR) and the quantitative Global Spectral Deconvolution (qGSD) method. The linearity range, quantitation limit, precision, robustness, and accuracy of these quantitative analysis methods were validated. The results indicated that both internal standards and integration methods met the requirements of the “9101 Guidelines for Analytical Method Validation” in the 2020 edition of the Chinese Pharmacopoeia. Compared to the traditional qNMR, qGSD has unique advantages in accurate quantitative analysis in complex systems. By using the combined HPLC-SPE-NMR technique, cefpodoxime proxetil iso-A and iso-B were enriched and analyzed, and their NMR data were accurately assigned. The quantitative analysis results were in line with the requirements of the Chinese Pharmacopoeia.
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    Analysis of plant resources and diversity in some areas of Inner Mongolia, China
    Terigen Bao, Minli, Jingming Jia , Anhua Wang
    2024 (6):  321-333. 
    摘要 ( 46 )   PDF(390KB) ( 32 )  
    Inner Mongolia Autonomous Region is located in the north of China. The vast area and complex terrain of this region make it rich in plant resources. The 11th Shenyang Pharmaceutical University Chinese Medicine Resources Scientific Expedition Team investigated the plant resources and diversity in some areas of Inner Mongolia through field investigation, literature review and specimen identification. From July to August, 2017, 215 species of vascular plants belonging to 59 families and 160 genera were collected. The dominant families are Ranunculaceae, Lamiaceae, Rosaceae, Fabaceae and Asteraceae, with 11, 12, 15, 19, and 37 species, respectively. There are 55 families, 132 genera and 163 species of medical plant recources in some areas of Inner Mongolia. 27 vascular plants are Mongolian Medicine. In a word, our research has updated the plant recources and diversity in all areas of Inner Mongolia. Furthermore, this study provides practical and meaningful suggestions for strengthening the protection and utilization of plant resources in some areas of Inner Mongolia, which is of great significance for maintaining local plant diversity.
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    Review on Croton crassifolius: From botanical characteristics to biotransformation and better utilization
    Guoyu Wang, Wenhan Wang, Xiaomeng Zhang, Yunpeng Yang, Yibo Wang, Yao Zhao, Yu Chen
    2024 (6):  334-341. 
    摘要 ( 35 )   PDF(6252KB) ( 22 )  
    Croton crassifolius (C. crassifolius) is a kind of traditional Chinese medicine, with a history hundreds of years in China. By consulting Sciencedirect databases and Web of Science databases, 68 related articles were found, 12 of which were related to chemical composition and pharmacological activity. It was used by the ancients as the medicine to treat stomach trouble, rheumatism, poliomyelitis and injuries, and it is the treasure of traditional Chinese medicine in China. With the development of  modern medicine, the active ingredients and therapeutic mechanism of C. crassifolius have been gradually revealed. In this study, the functions and applications of C. crassifolius were reviewed from the aspects of botany, traditional Chinese medicine therapy and biotransformation of substances, so as to better understand and use C. crassifolius and provide more effective drug choices for clinical treatment.
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    Chemical compositions and pharmacological activities of Xanthium strumarium
    Ruoming Li, Yunpeng Yang, Xiaomeng Zhang, Yibo Wang, Wenhan Wang, Yao Zhao , Yu Chen
    2024 (6):  342-352. 
    摘要 ( 39 )   PDF(3742KB) ( 24 )  
    Xanthium strumarium (X. strumarium) is a traditional Chinese medicine with a long history. In recent years, with the development of modern pharmacology and chemical analysis technology, research on X. strumarium has been deepend. This paper aims to systematically summarize the chemical compositions and pharmacological effects of X. strumarium, in order to provide theoretical basis and reference for further exploration in its clinical application and drug development.
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