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本期目录

    2024年, 第19卷, 第5期 刊出日期:2024-10-28 上一期    下一期
    Exploring the molecular mechanism of Corydalis yanhusuo against prostate cancer based on network pharmacology and molecular docking validation
    Ying Zhu#, Junwei Lu#, Jumin Xie
    2024 (5):  241-265. 
    摘要 ( 78 )   PDF(17701KB) ( 46 )  
    The molecular mechanism underlying Corydalis Yanhusuo’s therapeutic potential in prostate cancer (PCa) treatment was  elucidated using network pharmacology and molecular docking. Nineteen active ingredients, 399 drug targets, 1790 disease  targets and 143 intersection targets were identified. Ten core targets were screened from the protein-protein interaction network.  Enrichment analysis revealed 133 GO terms and 114 KEGG pathways. Corydalis Yanhusuo may potentially treat prostate cancer  through pathways such as the Rap1 signaling pathway, phospholipase D signaling pathway, Ras signaling pathway, VEGF  signaling pathway and JAK-STAT signaling pathway. Significant differences in expression were observed for EGFR, PDGFRA,  PIK3CA, PIK3CD, PIK3CG and PIK3R1. Molecular docking and dynamics simulation analysis showed low binding energy  between active components and the six core genes of Corydalis Yanhusuo, indicating a favorable docking effect. This study shows  that Corydalis Yanhusuo exhibits promise in prostate cancer treatment through a synergistic “multi-component-multi-targetmulti-pathway” effect.
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    Analysis of vascular plant resources and diversity in Liupan Mountains of Ningxia Province, China
    Dongdong Wang, Minli Ruan, Jingming Jia, Anhua Wang
    2024 (5):  266-274. 
    摘要 ( 65 )   PDF(371KB) ( 26 )  
    Liupan Mountains are situated in the south of Ningxia Hui Autonomous Region and east of Gansu Province. This area is rich in  forests and vegetation. After field investigation, literature review and specimen identification, the plant resources and diversity  of Liupan Mountains were studied by the 4th Shenyang Pharmaceutical University Chinese Medicine Resources Scientific  Expedition Team. There were 161 species of vascular plants belonging to 60 families and 119 genera collected from July to August  2010 in this area. Among them, the dominant families are Campanulaceae, Ranunculaceae, Orobanchaceae, Asparagaceae,  Fabaceae, Rosaceae and Asteraceae, with 6, 7, 8, 8, 10, 10, and 22 species, respectively. Although representing only 11.7% of the  total number of families, these families had a species occupancy rate of over 44.1%. At the genus level, Pedicularis is the most  dominant genus with 6 species, while 92 genera contain only 1 species, accounting for 77.3% of the total number of genera. In a  word, our research has updated the plant resources and diversity in Liupan Mountains. Furthermore, by providing practical and  meaningful suggestions for strengthening the protection and utilization of plant resources in Liupan Mountains, our research is  of great significance for maintaining the diverse ecosystem in this area.
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    A review: Research progress on multi-target neuroprotective effects of n-butylphthalide  extracted from Apium graveolens seeds #br#
    Jiahui Huo, Jingxian Ren, Xiaoxiao Huang, Xiaoliang Wang
    2024 (5):  275-284. 
    摘要 ( 0 )   PDF(5286KB) ( 0 )  
    Apium graveolens, an annual herb belonging to the family of Apiaceae, is widely distributed in North and South America,  Southern Europe, Africa and Asia. Apium graveolens seeds have a rich history in traditional Chinese medicine for treating  hypertension, headaches, vertigo and epilepsy. N-butylphthalide, originally extracted from Apium graveolens seeds, represents  a first-in-class drug developed independently in China. Its broad pharmacological activities on nervous system disorders have  garnered significant attention from researchers globally. This review focuses on the pharmacological research of n-butylphthalide  on central nervous system diseases, including ischemic stroke, Alzheimer’s disease, Parkinson’s disease and amyotrophic lateral  sclerosis. The purpose is to pave the way for future study on the mechanistic targets of n-butylphthalide.
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    Chemical composition and pharmacological activities of the Phellodendron chinense Schneid
    Yi′an Shi, Yunpeng Yang, Wenhan Wang, Yibo Wang, Yao Zhao, Yu Chen
    2024 (5):  285-298. 
    摘要 ( 52 )   PDF(2443KB) ( 29 )  
    Phellodendron chinense Schneid (P. chinense), as a traditional Chinese medicine, is commonly used in clinical practice. It has the  effects of drying dampness, clearing heat, detoxifying, purging fire, and reducing swelling. Its main chemical components are  flavonoids and alkaloids, which have various pharmacological effects such as lowering blood sugar, lowering blood pressure and  immunosuppression. With the continuous development of modern science and technology, the research on P. chinense Schneid  has increased. This study reviews the chemical components and pharmacological effects of P. chinense Schneid, and provides  reference for its further research and development.
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