亚洲传统医药

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1. Study on the mechanism of Euphorbia fischeriana Steud.-Jujubae Fructus in the treatment of hepatocirrhosis based on network pharmacology

Yanqiong Luo, Bo Hong, Ronghong Liu, Yu Zou, Yujiao Hou, Wenjing Li

亚洲传统医药 2024, 19 (2): 51-65.

摘要（115）

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The active components, targets, and pathways of Euphorbia fischeriana Steud.-Jujubae Fructus in treating hepatocirrhosis and the mechanism of action were explored by means of network pharmacology. Firstly, the active components and related targets of Jujubae Fructus were screened by TCMSP database and standardized by Uniprot database. The compounds of Euphorbia fischeriana Steud. were obtained by searching the literature and finally screened by PubChem database, Swiss ADME, and SwissTargetPrediction. Hepatocirrhosis targets were obtained through Genecards database, PPI network analysis was conducted on common targets of Euphorbia fischeriana Steud.-Jujubae Fructus and hepatocirrhosis by using String database, GO enrichment analysis and KEGG pathway enrichment analysis was conducted through Metascape database by using intersection targets of Euphorbia fischeriana Steud.-Jujubae Fructus and hepatocirrhosis, and the results were drawn by using Weishengxin online drawing platform. Then, the network of drug-compound-target-pathway was constructed by the software of Cytoscape3.8.0. Finally, the above results were verified by molecular docking. 47 active compounds from Euphorbia fischeriana Steud.-Jujubae Fructus were screened out, which had 38 common targets, 162 intersection targets, and 340 signal pathways with hepatocirrhosis, mainly involving hepatitis C, JAK-STAT signal pathway and AGE-RAGE signal pathway. Targets, such as MAPK1, AKT1, TNF, JUN, IL6 and PTGS2, play important roles in the treatment. The findings suggested that the main active ingredients of Euphorbia fischeriana Steud.-Jujubae Fructus in treating hepatocirrhosis are quercetin, scopolamine, physcion, 7-deoxyrangduin, 17-Hydroxyjolkinolide A, etc. Molecular docking results showed that the main active components and core targets might have a good binding capacity. This study preliminarily explored the potential mechanism of Euphorbia fischeriana Steud.-Jujubae Fructus in treating hepatocirrhosis and provided a theoretical basis for the clinical application of Euphorbia fischeriana Steud.-Jujubae Fructus.

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2. UV, five wavelengths fusion and electrochemical fingerprints combined with antioxidant activity for quality control of antiviral mixture

Kaining Zhou, Zini Tang, Guoxiang Sun, Ping Guo, Lili Lan

亚洲传统医药 2024, 19 (3): 119-136.

摘要（87）

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Aiming to ensure the consistency of quality control of Traditional Chinese Medicines (TCMs), a combination method of high-erformance liquid chromatography (HPLC), ultraviolet (UV), electrochemical (EC) was developed in this study to comprehensively evaluate the quality of Antiviral Mixture (AM), and Comprehensive Linear Quantification Fingerprint Method (CLQFM) was used to process the data. Quantitative analysis of three active substances in TCM was conducted. A five-wavelength fusion fingerprint (FWFF) was developed, using second-order derivatives of UV spectral data to differentiate sample levels effectively. The combination of HPLC and UV spectrophotometry, along with electrochemical fingerprinting (ECFP), successfully evaluated total active substances. Ultimately, a multidimensional profiling analytical system for TCM was developed.

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3. Plant resources and diversity analysis of Sejila Mountain in southeast Tibet

Lianyu Tang, Dongdong Wang, Jingming Jia, Anhua Wang

亚洲传统医药 2024, 19 (3): 152-158.

摘要（78）

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Sejila Mountain is located in Linzhi City, southeast Tibet. The terrain is high, and the climate is cold and dry. The special ecological environment determines the richness and diversity of plant resources. In this study, the plant resources and diversity of Sejila Mountain were studied through field investigation, literature review and specimen identification. 282 plant species belonging to 199 genera and 81 families were collected from July to August in 2021. The dominant families are Asteraceae, Ranunculaceae and Rosaceae. In terms of life form, perennial herbs are the main form, accounting for 58.16% of the total. 178 species of medicinal plants were collected, including 33 species of Tibetan medicine. In terms of medicinal parts, the whole grass is mainly used as medicine, followed by roots and rhizomes. In conclusion, our study has updated the plant resources and diversity of Sejila Mountain. Based on the investigation and research, some suggestions were put forward to strengthen the protection and utilization of the plant resources in Sejila Mountain.

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4. Analysis of vascular plant resources and diversity in Fanjing Mountain, Guizhou Province

Hu Chen, Guoqing Long, Anhua Wang, Jingming Jia

亚洲传统医药 2024, 19 (3): 137-151.

摘要（75）

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Fanjing Mountain Nature Reserve is located at the junction of Jiangkou, Yinjiang and Songtao counties in the Tongren region of Guizhou Province. Because of the topography and humid climate of the central subtropical monsoonal mountains, the plant species in this area are rich and diverse. The vascular plant resources and diversity of Fanjing Mountain Nature Reserve in Guizhou Province were studied through field survey, literature review and specimen identification. The results show that there are 284 species of vascular plants in the region, belonging to 205 genera in 93 families, mainly angiosperms. Liliaceae, Asteraceae, Polygonaceae, Leguminosae, Ranunculaceae and Polygonum have the most species, followed by Sedum, Dioscorea, Actinidia Lindl and Thalictrum. In terms of life types, perennial herbs are the most dominant, accounting for 68.47% of the total number of species, and annual (or biennial) herbs, shrubs and vine types also present. There are 222 species identified as medicinal vascular plants, accounting for 78.2% of the total number of species. The medicinal parts are primarily found in the whole herb category, followed by the root and rhizome category.

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5. Comprehensive analysis of phenolic composition and antioxidant mechanisms in Gymnema sylvestre extracts using LC-MS and column chromatography

Shengjie Hao, Yuxin Du, Jianglong He, Qian Li, Guilin Chen

亚洲传统医药 2024, 19 (4): 211-222.

摘要（75）

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Recent studies have highlighted the potential of plant extracts as therapeutic agents for managing oxidative stress and related disorders. This study aims to elucidate the phenolic composition and antioxidant properties of Gymnema sylvestre extracts. Ethanolic reflux extraction followed by column chromatography was employed to isolate phenolic compounds. The total phenolic and flavonoid contents were quantified using the Folin–Ciocalteu and aluminum chloride colorimetric methods, respectively. Antioxidant activities were assessed by DPPH, ABTS scavenging assays and the ferric reducing antioxidant power (FRAP) assay. High-Performance Liquid Chromatography (HPLC) with a C18 column and Thermo TSQ Quantum Access Max (LC-MS) were used to determine the levels of gymnemic acid and identify other potential phenolic compounds. The analysis revealed significant antioxidant activities in the fractions. Fraction A showed the highest DPPH and ABTS scavenging activities, and Fraction C demonstrated the highest ferric reducing power. LC-MS analysis identified several phenolic compounds, indicating that these are major contributors to the antioxidant efficacy of the extract. This study provides a detailed phenolic profile and confirms the strong antioxidant potential of Gymnema sylvestre leaf extract, supporting its therapeutic use and further investigation.

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6. Chemical constituents and pharmacological effects of Croton crassifolius#br# #br#

Luyan Yang, Yibo Wang, Xinyao Wang, Xiaoxia Xu , Yunpeng Yang, Meng Zhang, Yu Chen

亚洲传统医药 2024, 19 (2): 99-114.

摘要（73）

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Croton crassifolius (CC) is a kind of traditional Chinese medicine rich in terpenoids, with among which diterpene species are the most. CC had biological activities in the treatment of cancer, inflammation, ulcerative colitis, osteoporosis and Alzheimer’s disease. This study reviews the chemical compositions and pharmacological activities of CC to provide reference for further research.

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7.

Exploring the molecular mechanism of Corydalis yanhusuo against prostate cancer based on network pharmacology and molecular docking validation

Ying Zhu#, Junwei Lu#, Jumin Xie

亚洲传统医药 2024, 19 (5): 241-265.

摘要（72）

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The molecular mechanism underlying Corydalis Yanhusuo’s therapeutic potential in prostate cancer (PCa) treatment was elucidated using network pharmacology and molecular docking. Nineteen active ingredients, 399 drug targets, 1790 disease targets and 143 intersection targets were identified. Ten core targets were screened from the protein-protein interaction network. Enrichment analysis revealed 133 GO terms and 114 KEGG pathways. Corydalis Yanhusuo may potentially treat prostate cancer through pathways such as the Rap1 signaling pathway, phospholipase D signaling pathway, Ras signaling pathway, VEGF signaling pathway and JAK-STAT signaling pathway. Significant differences in expression were observed for EGFR, PDGFRA, PIK3CA, PIK3CD, PIK3CG and PIK3R1. Molecular docking and dynamics simulation analysis showed low binding energy between active components and the six core genes of Corydalis Yanhusuo, indicating a favorable docking effect. This study shows that Corydalis Yanhusuo exhibits promise in prostate cancer treatment through a synergistic “multi-component-multi-targetmulti-pathway” effect.

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8. Chemical composition and pharmacological activities ofAtractylodes lancea: A review

Shuo Wang, Yunpeng Yang, Yibo Wang, Wenhan Wang, Meng Zhang, Yu Chen

亚洲传统医药 2024, 19 (3): 159-171.

摘要（68）

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Atractylodes lancea (called Cangzhu in China) is a medicinal plant that has long been used as tonic agent in various ethno-medical systems in East Asia, especially in China, for the treatment of gastrointestinal dysfunction, cancer, osteoporosis, obesity and fetal irritability. We used the TCMSP database to search for the main active ingredients and traditional Chinese medicine targets of Atractylodes macrocephala. There are a total of 38 related articles, of which 27 are closely related to chemical composition and activity. This study reviews the chemical components and pharmacological effects of A. lancea, aiming to provide reference for its further research and development.

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9.

The mechanism analysis of KangBingDuKouFuYe in treating throat infection based on network pharmacology and molecular docking

Ying Long# , Xinhui Yang# , Hongfei Lv, Zhenyu Liu, Tianjun Guo, Chaohui Yang, Hui Liu, Qijia Yang, Xin Wu

亚洲传统医药 2025, 20 (1): 1-13.

摘要（66）

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KangBingDuKouFuYe (KBDKFY) is widely used to treat inffuenza, upper respiratory tract infections, mumps and other diseases. Due to their diverse active ingredients, it is believed that they may have excellent anti-inflammatory, antibacterial and antiviral effects. Therefore, we believe they may have multiple therapeutic targets for throat inflammation caused by bacterial or viral infections. This study utilizes network pharmacology methods to analyze the therapeutic effects of KBDKFY on Bacterial Pharyngeal Tonsillitis and Viral Pharyngitis, aiming to identify its active ingredients, action targets and related pathways through molecular docking. Additionally, it determines the afffnity between the main active ingredient and the core target before conducting in vitro bacteriostatic tests. The analysis results show that KBDKFY contains multiple active ingredients and potential targets for treating Bacterial Pharyngeal Tonsillitis and Viral Pharyngitis. KEGG enrichment analysis indicates that KBDKFY may have therapeutic effects on these conditions through pathways such as pathways in cancer, Kaposi sarcoma-associated herpesvirus infection, PI3K-Akt signaling pathway, and others. This provides a theoretical basis for further exploring pharmacological effects and clinical applications of KBDKFY.

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10. Analysis of plant resources and diversity in the southeast area of Taihang Mountains#br# #br#

Junpeng Lin, Jingming Jia, Anhua Wang

亚洲传统医药 2024, 19 (2): 88-98.

摘要（65）

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Taihang Mountains are situated between Shanxi Province and the North China Plain, spanning Beijing, Hebei, Shanxi, and Henan provinces and cities. The mountains extend from northeast to southwest for over 400 km, naturally deviding the second step from the third one in China. The southeastern area of Taihang Mountains specifically refers to Changzhi City and Jincheng Administrative Region of Shanxi Province. Given Shanxi Province’s robust development plans for the southeast area of Taihang Mountains, the medicinal plant resources in this area will be affected. Therefore, it is imperative and urgent to conduct a comprehensive investigation and study on the medicinal plant resources in the southeast area of Taihang Mountains. By means of field investigation, literature review, and specimen identification, the plant resources and diversity of two counties in the southeast of Taihang Mountains were evaluated. The findings revealed 234 plants species across 172 genera in 70 families, primarily comprising angiosperms. The families with more species included Compositae, Leguminosae, Rosaceae, Labiatae, Ranunculaceae. Among the genera, those with more species were Cynanchum, Selaginella, Clematis, Thalictrum, and Rhamnus. A total of 114 medicinal plants were identified, constituting 48.72% of the total. Regarding medicinal parts, the concentration is in roots and rhizomes, followed by whole plants and fruits. On the basis of investigation and study, some suggestions on the development, utilization, and protection of medicinal plant resources in southeast Taihang Mountains were made. These suggestions provide valuable insights for the study on medicinal plant resources and vegetation in the southeast of Taihang Mountains, serving as a scientific basis for the protection and sustainable utilization of wild medicinal plant resources.

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11. Chemical composition and biological activity of Houttuynia cordata

Yibo Wang, Yunpeng Yang, Xinyao Wang, Wenhan Wang, Luming Pan, Yu Chen

亚洲传统医药 2024, 19 (4): 223-234.

摘要（62）

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Houttuynia cordata is an important traditional Chinese medicine. It is widely used for clearing heat and detoxification, reducing swelling and treating sores, diuresis and dehumidification. It is also used to treat lung carbuncles, ulcers, hemorrhoids, rectal bleeding, spleen and stomach heat, which are caused by excess heat, heat toxicity, dampness, and disease heat. Modern pharmacological experiments have shown that H. cordata has antibacterial, antiviral, immune enhancing, diuretic and other effects. This article reviews the chemical components and biological activities of H. cordata to provide reference for clinical application.

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12.

Analysis of vascular plant resources and diversity in Liupan Mountains of Ningxia Province, China

Dongdong Wang, Minli Ruan, Jingming Jia, Anhua Wang

亚洲传统医药 2024, 19 (5): 266-274.

摘要（59）

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Liupan Mountains are situated in the south of Ningxia Hui Autonomous Region and east of Gansu Province. This area is rich in forests and vegetation. After field investigation, literature review and specimen identification, the plant resources and diversity of Liupan Mountains were studied by the 4th Shenyang Pharmaceutical University Chinese Medicine Resources Scientific Expedition Team. There were 161 species of vascular plants belonging to 60 families and 119 genera collected from July to August 2010 in this area. Among them, the dominant families are Campanulaceae, Ranunculaceae, Orobanchaceae, Asparagaceae, Fabaceae, Rosaceae and Asteraceae, with 6, 7, 8, 8, 10, 10, and 22 species, respectively. Although representing only 11.7% of the total number of families, these families had a species occupancy rate of over 44.1%. At the genus level, Pedicularis is the most dominant genus with 6 species, while 92 genera contain only 1 species, accounting for 77.3% of the total number of genera. In a word, our research has updated the plant resources and diversity in Liupan Mountains. Furthermore, by providing practical and meaningful suggestions for strengthening the protection and utilization of plant resources in Liupan Mountains, our research is of great significance for maintaining the diverse ecosystem in this area.

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13. Analysis of wild medicinal vascular plant resources and diversity in Dabie Mountains, Anhui Province

Qing Wang, Minli Ruan, Anhua Wang, Jingming Jia

亚洲传统医药 2024, 19 (4): 192-210.

摘要（59）

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Dabie Mountains are located at the junction of Anhui, Henan and Hubei provinces in the East of China. With its varied altitude, climate, and soil texture, Dabie Mountains are extremely rich in wild plant resources. The 12th Traditional Chinese Medicine (TCM) Resources Scientific Expedition Team of Shenyang Pharmaceutical University conducted a study on wild vascular plants resources, especially medicinal vascular plants, through field investigation, literature review and specimen identification. There were 472 species of vascular plants belonging to 347 genera and 125 families collected during July 2018 in this area, of which 424 species were medicinal vascular plants, accounting for 89.83% of the total. From the perspective of medicinal parts, most of the medicinal plants there have values in their roots and rhizomes, as well as the whole plants. The efficacy and characteristics of these pharmaceutical dimensions were also summarized and analyzed in detail. Besides, among the wild vascular plants collected, the most dominant families with the biggest numbers of species are Compositae, Lamiaceae, Liliaceae, Rosaceae, Leguminosae, Ranunculaceae, Saxifragaceae and Polygonaceae, and the dominant genus are Viola and Sedum. In terms of life form, perennial herbs are dominant, accounting for 55.72% of the total species, followed by some annual (or biennial) herbs, shrubs and lianas. Finally, recommendations are put forward for strengthening the protection and utilization of wild medicinal plant resources in Dabie Mountains.

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14. Analysis of plant resources and diversity in Shennongjia Area of Hubei Province, China#br# #br#

Terigen Bao , Min Li , Jingming Jia, Anhua Wang

亚洲传统医药 2024, 19 (2): 66-87.

摘要（58）

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Shennongjia Area is located in northwest of Hubei Province with Shennongding, the highest peak (3105.4 m above sea level) in central China. The unique geographical location and complex terrain of this region make it rich in plant resources. After field investigation, literature review, and specimen identification, the 7th Shenyang Pharmaceutical University Chinese Medicine Resources Scientific Expedition Team studied the plant resources and diversity of Shennongjia Area. 454 species of vascular plants belonging to 106 families and 275 genera were collected from July to August in 2013. The dominant families are Lamiaceae, Ranunculaceae, Rosaceae, and Asteraceae, with 20, 21, 37 and 48 species respectively. At the genus level, Rubus is the dominant one with 11 species. 3 species of national first-class protective plants, 13 species of “Huan yang yao” and 36 species of “Qi yao” were collected. In all, our research has updated the plant recources and diversity in Shennongjia Area. Furthermore, by putting forward practical and meaningful suggestions on strengthening the protection and utilization of plant resources in Shennongjia Area, our research will help to protect the diverse ecosystem there.

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15. Network pharmacology to decipher the mechanism of Danggui Longhui Wan against chronic myeloid leukemia

Xuehan Ma, Qiulin Yan, Shaojiang Song, Guodong Yao

亚洲传统医药 2024, 19 (4): 177-191.

摘要（57）

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Chronic myeloid leukemia (CML) is a hematopoietic myeloproliferative disorder. The Chinese prescription Danggui Longhui Wan (DGLHW) has been utilized in CML treatment, but its underlying mechanisms remain unclear. In this study, we gathered 794 constituents, 1249 drug targets, 1654 disease genes and 129 intersection genes. GO and KEGG were used to analyze the function of these genes. Compatibility of prescription study showed that monarch drug, minister drug, assistant and guide drug played a synergistic role in the treatment of CML. In addition, we obtained 20 hub genes and 12 key components. Molecular docking indicated that the main compounds and core proteins had good binding ability. The results of this study also showed that DGLHW might play a role in the treatment of CML by affecting MAPK, PI3K/AKT, FoxO and p53 signaling pathways.

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16.

Quantitative analysis of Cefpodoxime Proxetil raw material and dry suspension using proton nuclear magnetic resonance

Yufei Liu, Bin Li, Xinyu Tao, Dongyang Zhao, Xinyu Zhang, Yan Wu, Wenyi He, Chenggen Zhu, Xiangju Jin, Hongyue Liu, Xin Di, Ye Tian, Yanan Wang

亚洲传统医药 2024, 19 (6): 305-320.

摘要（49）

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This study established a simple, rapid, and accurate nuclear magnetic resonance (NMR) quantitative method to determine the cefpodoxime proxetil content in raw materials and dry suspensions, and evaluated the uncertainty. The relative content of cefpodoxime proxetil iso-A and iso-B was also analyzed based on 1 H NMR. In this study, an internal standard method was used, with DMSO-d 6 as the solvent and maleic acid and 1,3,5-trimethylbenzene as internal standards, to calculate the concentration of the samples. Quantitative analysis was performed using both the traditional quantitative NMR (traditional qNMR) and the quantitative Global Spectral Deconvolution (qGSD) method. The linearity range, quantitation limit, precision, robustness, and accuracy of these quantitative analysis methods were validated. The results indicated that both internal standards and integration methods met the requirements of the “9101 Guidelines for Analytical Method Validation” in the 2020 edition of the Chinese Pharmacopoeia. Compared to the traditional qNMR, qGSD has unique advantages in accurate quantitative analysis in complex systems. By using the combined HPLC-SPE-NMR technique, cefpodoxime proxetil iso-A and iso-B were enriched and analyzed, and their NMR data were accurately assigned. The quantitative analysis results were in line with the requirements of the Chinese Pharmacopoeia.

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17. Chemical composition and pharmacological activities of the Phellodendron chinense Schneid

Yi′an Shi, Yunpeng Yang, Wenhan Wang, Yibo Wang, Yao Zhao, Yu Chen

亚洲传统医药 2024, 19 (5): 285-298.

摘要（45）

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Phellodendron chinense Schneid (P. chinense), as a traditional Chinese medicine, is commonly used in clinical practice. It has the effects of drying dampness, clearing heat, detoxifying, purging fire, and reducing swelling. Its main chemical components are flavonoids and alkaloids, which have various pharmacological effects such as lowering blood sugar, lowering blood pressure and immunosuppression. With the continuous development of modern science and technology, the research on P. chinense Schneid has increased. This study reviews the chemical components and pharmacological effects of P. chinense Schneid, and provides reference for its further research and development.

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18.

Analysis of plant resources and diversity in some areas of Inner Mongolia, China

Terigen Bao, Minli, Jingming Jia , Anhua Wang

亚洲传统医药 2024, 19 (6): 321-333.

摘要（41）

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Inner Mongolia Autonomous Region is located in the north of China. The vast area and complex terrain of this region make it rich in plant resources. The 11th Shenyang Pharmaceutical University Chinese Medicine Resources Scientific Expedition Team investigated the plant resources and diversity in some areas of Inner Mongolia through field investigation, literature review and specimen identification. From July to August, 2017, 215 species of vascular plants belonging to 59 families and 160 genera were collected. The dominant families are Ranunculaceae, Lamiaceae, Rosaceae, Fabaceae and Asteraceae, with 11, 12, 15, 19, and 37 species, respectively. There are 55 families, 132 genera and 163 species of medical plant recources in some areas of Inner Mongolia. 27 vascular plants are Mongolian Medicine. In a word, our research has updated the plant recources and diversity in all areas of Inner Mongolia. Furthermore, this study provides practical and meaningful suggestions for strengthening the protection and utilization of plant resources in some areas of Inner Mongolia, which is of great significance for maintaining local plant diversity.

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19.

Chemical compositions and pharmacological activities of Xanthium strumarium

Ruoming Li, Yunpeng Yang, Xiaomeng Zhang, Yibo Wang, Wenhan Wang, Yao Zhao , Yu Chen

亚洲传统医药 2024, 19 (6): 342-352.

摘要（33）

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Xanthium strumarium (X. strumarium) is a traditional Chinese medicine with a long history. In recent years, with the development of modern pharmacology and chemical analysis technology, research on X. strumarium has been deepend. This paper aims to systematically summarize the chemical compositions and pharmacological effects of X. strumarium, in order to provide theoretical basis and reference for further exploration in its clinical application and drug development.

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20. Chemical composition and biological activities of Lysimachia capillipes Hemsl

Ran Guo, Ruoming Li, Xiaomeng Zhang, Wenhan Wang, Yao Zhao, Yu Chen

亚洲传统医药 2025, 20 (1): 14-29.

摘要（31）

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Lysimachia capillipes (L. capillipes) Hemsl, belong to primulaceae pearl vegetables genus, is a treasure in traditional Chinese medicine. It has the effects of invigorating qi and tonifying deffciency, dispelling wind and activating blood, awakening the brain, relieving cough and regulating menstruation. With the development of modern medicine, the active components and therapeutic mechanisms of L. capillipes Hemsl have been gradually revealed. The present report systematically reviews the chemical composition and biological activities of L. capillipes Hemsl, to provide scientiffc basis and reference for detailed research on L. capillipes Hemsl.

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21.

Review on Croton crassifolius: From botanical characteristics to biotransformation and better utilization

Guoyu Wang, Wenhan Wang, Xiaomeng Zhang, Yunpeng Yang, Yibo Wang, Yao Zhao, Yu Chen

亚洲传统医药 2024, 19 (6): 334-341.

摘要（30）

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Croton crassifolius (C. crassifolius) is a kind of traditional Chinese medicine, with a history hundreds of years in China. By consulting Sciencedirect databases and Web of Science databases, 68 related articles were found, 12 of which were related to chemical composition and pharmacological activity. It was used by the ancients as the medicine to treat stomach trouble, rheumatism, poliomyelitis and injuries, and it is the treasure of traditional Chinese medicine in China. With the development of modern medicine, the active ingredients and therapeutic mechanism of C. crassifolius have been gradually revealed. In this study, the functions and applications of C. crassifolius were reviewed from the aspects of botany, traditional Chinese medicine therapy and biotransformation of substances, so as to better understand and use C. crassifolius and provide more effective drug choices for clinical treatment.

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22.

Research progress of different kinds of traditional Chinese medicine in the treatment of type 2 diabetes

Yuzheng Xiang, Xiaomeng Zhang, Ruoming Li, Wenhan Wang, Yao Zhao, Yu Chen

亚洲传统医药 2025, 20 (1): 30-42.

摘要（29）

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In recent years, diabetes has posed a serious threat to human health. Traditional Chinese medicine for lowering blood sugar has attracted much attention due to its unique advantages in the treatment of diabetes. This paper summarizes the research results on common traditional Chinese medicines for lowering blood sugar in recent years. These results lay a theoretical foundation for the future clinical development and use of hypoglycemic Chinese medicine, the improvement of the quality standards of hypoglycemic Chinese medicine, and the in-depth research on the mechanisms.

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23.

A review: Research progress on multi-target neuroprotective effects of n-butylphthalide extracted from Apium graveolens seeds #br#

Jiahui Huo, Jingxian Ren, Xiaoxiao Huang, Xiaoliang Wang

亚洲传统医药 2024, 19 (5): 275-284.

摘要（0）

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Apium graveolens, an annual herb belonging to the family of Apiaceae, is widely distributed in North and South America, Southern Europe, Africa and Asia. Apium graveolens seeds have a rich history in traditional Chinese medicine for treating hypertension, headaches, vertigo and epilepsy. N-butylphthalide, originally extracted from Apium graveolens seeds, represents a first-in-class drug developed independently in China. Its broad pharmacological activities on nervous system disorders have garnered significant attention from researchers globally. This review focuses on the pharmacological research of n-butylphthalide on central nervous system diseases, including ischemic stroke, Alzheimer’s disease, Parkinson’s disease and amyotrophic lateral sclerosis. The purpose is to pave the way for future study on the mechanistic targets of n-butylphthalide.

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