Uncovering the potential targets of Viburnum odoratissimum for
the treatment of related diseases

亚洲传统医药 ›› 2020, Vol. 15 ›› Issue (6): 328-359.

• Regular Article • 上一篇下一篇

Uncovering the potential targets of Viburnum odoratissimum for the treatment of related diseases

Xiaobian Xue 1, Guodong Yao 1,2*

1. Key Laboratory of Computational Chemistry-Based Natural Antitumor Drug Research & Development, Liaoning Province, School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, China; 2. Jiangsu Kanion Pharmaceutical Company Ltd., Lianyungang 222001, China

收稿日期:2020-07-19 接受日期:2020-09-22 出版日期:2020-12-20 发布日期:2020-12-23

Uncovering the potential targets of Viburnum odoratissimum for the treatment of related diseases

Xiaobian Xue 1, Guodong Yao 1,2*

1. Key Laboratory of Computational Chemistry-Based Natural Antitumor Drug Research & Development, Liaoning Province, School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, China; 2. Jiangsu Kanion Pharmaceutical Company Ltd., Lianyungang 222001, China

Received:2020-07-19 Accepted:2020-09-22 Online:2020-12-20 Published:2020-12-23
Contact: School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, 103 Wenhua Rd., Shenyang 110016, China; Tel.: +86-24-23986510; E-mail: guodong_yao@163.com. E-mail:guodong_yao@163.com

摘要/Abstract

摘要： Viburnum odoratissimum, a landscape plant, is rich in vibsane-type diterpenes, triterpenes, monoterpenoids, sesquiterpenoids, coumarins, and lignans and so on. In the present work, network analysis was carried out to predict the potential targets of V. odoratissimum and the treatment of related diseases. 13 main target proteins were predicted, as well as the diseases which might interact with the compounds from V. odoratissimum. The results showed that vibsane-type diterpenes and triterpenes had the potential to treat neoplasm-related and inflammation-related diseases, and the key target proteins were MDM2, NOS, AR, DNMT1, NR3C1, RARA and PTPN1. Among them, AR, NOS, DNMT1, NR3C1, DNMT1 and PTPN1 were also the crucial targets for triterpenes in the treatment of diabetes mellitus. Besides, ALOX15, PIPN1, TLR9, MIT, DNMT1, RAC1, RTGS2, RARA and ACHE were the potential targets for coumarins and lignan in the treatment of neoplasm-related diseases. Furthermore, ESR1, AR, NOS2, NR3C1 were the primary targets for monoterpenoids and sesquiterpenoids because of their potential neuroprotective effects. It is noteworthy that the study of the potential targets and related diseases can provide new insights for further development of V. odoratissimum.

关键词: Viburnum odoratissimum, target proteins, network, diseases

Abstract: Viburnum odoratissimum, a landscape plant, is rich in vibsane-type diterpenes, triterpenes, monoterpenoids, sesquiterpenoids, coumarins, and lignans and so on. In the present work, network analysis was carried out to predict the potential targets of V. odoratissimum and the treatment of related diseases. 13 main target proteins were predicted, as well as the diseases which might interact with the compounds from V. odoratissimum. The results showed that vibsane-type diterpenes and triterpenes had the potential to treat neoplasm-related and inflammation-related diseases, and the key target proteins were MDM2, NOS, AR, DNMT1, NR3C1, RARA and PTPN1. Among them, AR, NOS, DNMT1, NR3C1, DNMT1 and PTPN1 were also the crucial targets for triterpenes in the treatment of diabetes mellitus. Besides, ALOX15, PIPN1, TLR9, MIT, DNMT1, RAC1, RTGS2, RARA and ACHE were the potential targets for coumarins and lignan in the treatment of neoplasm-related diseases. Furthermore, ESR1, AR, NOS2, NR3C1 were the primary targets for monoterpenoids and sesquiterpenoids because of their potential neuroprotective effects. It is noteworthy that the study of the potential targets and related diseases can provide new insights for further development of V. odoratissimum.

Key words: Viburnum odoratissimum, target proteins, network, diseases

Xiaobian Xue, Guodong Yao. Uncovering the potential targets of Viburnum odoratissimum for the treatment of related diseases[J]. 亚洲传统医药, 2020, 15(6): 328-359.

Xiaobian Xue, Guodong Yao. Uncovering the potential targets of Viburnum odoratissimum for the treatment of related diseases[J]. Asian Journal of Traditional Medicines, 2020, 15(6): 328-359.

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Uncovering the potential targets of Viburnum odoratissimum for the treatment of related diseases

Uncovering the potential targets of Viburnum odoratissimum for the treatment of related diseases

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