Comparison of the Effects of Long-term and Short-term Treatment of Powder from Soft-shell Turtle on Bone Loss and Reduction in Bone Strength in OVX Rats

›› 2006, Vol. 1 ›› Issue (1): 15-19.

Comparison of the Effects of Long-term and Short-term Treatment of Powder from Soft-shell Turtle on Bone Loss and Reduction in Bone Strength in OVX Rats

收稿日期:2006-01-01 修回日期:2006-01-01 出版日期:2006-02-15 发布日期:2006-02-15

Comparison of the Effects of Long-term and Short-term Treatment of Powder from Soft-shell Turtle on Bone Loss and Reduction in Bone Strength in OVX Rats

Jun Yin*¹; Zhihui Liu¹; Subehan²; Junya Ueda²; Katsumichi Matsushige²; and
Shigetoshi Kadota²

1 Shenyang Pharmaceutical University, 103 Wenhua Road, Shenyang, China, 2 Institute of Natural Medicine, Toyama Medical and Pharmaceutical University, 2630 Sugitani, Toyama 930-0194, Japan

Received:2006-01-01 Revised:2006-01-01 Online:2006-02-15 Published:2006-02-15
Contact: Jun Yin

摘要/Abstract

Abstract: The comparative effects of long-term and short-term treatment with the powder of soft-shell turtle
(Trionyx sinensis)( SST) on the proximal tibiae of ovariectomized (OVX) rats were investigated by scanning
bones using peripheral quantitative computed tomography (pQCT). Initially, oral administration of SST (100
and 500 mg/kg) 3 times weekly was carried out for 6 weeks without any effect on preventing bone loss except
for inhibiting the reduction in bone mineral density (BMD) in cancellous bone; then SST (100 and 200 mg/kg)
3 times weekly was administered for six months and in the high dose group, it prevented the reduction in bone
mineral content (BMC) in total bone, BMC and bone mineral density (BMD) in cortical bone and bone
strength indexes induced by OVX, in a dose-dependent manner without any side effects on the uterus.

Key words: Trionyx sinensis, antiosteoporotic activity, OVX, peripheral quantitative computed tomography.

. Comparison of the Effects of Long-term and Short-term Treatment of Powder from Soft-shell Turtle on Bone Loss and Reduction in Bone Strength in OVX Rats[J]. , 2006, 1(1): 15-19.

Jun Yin*;Zhihui Liu;Subehan;Junya Ueda;Katsumichi Matsushige;and Shigetoshi Kadota. Comparison of the Effects of Long-term and Short-term Treatment of Powder from Soft-shell Turtle on Bone Loss and Reduction in Bone Strength in OVX Rats[J]. , 2006, 1(1): 15-19.

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Comparison of the Effects of Long-term and Short-term Treatment of Powder from Soft-shell Turtle on Bone Loss and Reduction in Bone Strength in OVX Rats

Comparison of the Effects of Long-term and Short-term Treatment of Powder from Soft-shell Turtle on Bone Loss and Reduction in Bone Strength in OVX Rats

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