亚洲传统医药

本期目录

2022年, 第17卷, 第2期　刊出日期：2022-04-24 上一期    下一期

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Network pharmacology-based virtual screening of the active volatile oil ingredients of Litsea lancilimba Merr. and their potential targets for treating liver cancer Yijie Zhang, Ming Bai, Weiyu Zhou, Xiaoxiao Huang, Shaojiang Song 2022 (2):  47-50.  摘要 ( 281 )   PDF(1267KB) ( 373 )   Liver cancer remains the dominant cause of cancer-related death, despite the advent of targeted therapies and immunotherapies. Therefore, there is an urgent need to explore novel chemotherapeutic agents and effective strategies against the cancer. There are a lot of monoterpenes and sesquiterpenoids in L. lancilimba. It has been reported that monoterpenes and sesquiterpenoids have certain anti-tumor effects. Literature investigation has also shown that Litsea lancilimba Merr. has antibacterial and antiviral effects. In this experiment, we used network pharmacology to screen the active compounds from L. lancilimba and their potential targets for treating liver cancer. Four active volatile oil ingredients and four potential targets have been identified. Our results provide the lead compound from L. lancilimba in the treatment of liver cancerv. 相关文章 | 计量指标

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Molecular mechanism of Salvia miltiorrhiza Bunge and Carthamus tinctorius L. in the treatment of myocardial ischemia based on network pharmacology: a comparative study Ronghong Liu, Yanping Wang, Wenjing Li, Bo Hong 2022 (2):  51-64.  摘要 ( 0 )   PDF(7284KB) ( 0 )   Based on network pharmacology and molecular docking technology, the similarities and differences of anti-myocardial ischemia mechanism between Salvia miltiorrhiza Bunge (SM) and Carthamus tinctorius L. (CT) were studied. Firstly, based on the traditional Chinese medicine systems pharmacology (TCMSP), the related compounds of SM and CT were obtained, and the potential targets of these compounds were collected by the target fishing method. Genecards database was used to obtain targets related to myocardial ischemia. The cross targets of CT, SM, and myocardial ischemia were then selected, and the protein-protein interaction (PPI) network was constructed based on the STRING database. The cross targets were imported into the Metascape database for Gene Oncology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) analysis. Cytoscape software was used to build the topological network diagram of the drug-compound-target path. Finally, the binding ability of the active ingredient and the key target was verified by molecular docking. 65 active ingredients and 38 potential targets were screened from SM, and 22 active ingredients and 58 potential targets were excavated from CT. Important targets common to SM and CT were TNF, IL6, VEGFA, AKT1, etc. The common enrichment pathways involved are fluid shear stress and atherosclerosis, IL-17 signaling pathway, pathways in cancer, and toxoplasmosis. The findings suggested that the two traditional Chinese medicines exerted the effect of myocardial ischemia through the characteristics of multiple targets, multiple pathways, and multiple compounds. 相关文章 | 计量指标

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Research review on the chemical constituents and pharmacological effects of Viburnum opulus Defeng Liu, Ming Bai, Peng Zhao, Xiaoxiao Huang 2022 (2):  65-71.  摘要 ( 411 )   PDF(1175KB) ( 518 )   Viburnum opulus, belonging to Viburnum of Caprifoliaceae family, is commonly used as a Chinese herbal medicine. Many chemical constituents have been isolated from V. opulus, including flavonoids, flavone glycosides, volatile oils and terpenoids. It has antioxidant, antibacterial, antispasmodic, and anticancer effects. V. opulus, with a variety of chemical constituents and remarkable activities, has attracted wide attention. Hence, this report is presented as a review centered on the chemical constituents and pharmacological activities of V. opulus, in order to provide reference for further research and development of Viburnum opulus. 相关文章 | 计量指标

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Research progress on polysaccharide compositions of Dendrobium officinale Lili Wang, Liu Bai 2022 (2):  72-83.  摘要 ( 366 )   PDF(1808KB) ( 656 )   More and more attention has been paid to the polysaccharide components of Dendrobium officinale (D. officinale). They are rich in active components and have extensive pharmacological effects. This paper systematically summarized the extraction, separation, purification process, content determination, chemical compositions and pharmacological activities of D. officinale polysaccharides, which provided the basis for the preparation, quality control and further development and utilization of the medicinal materials. 相关文章 | 计量指标