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In Vitro Anticariogenic Activity of Some Indian
Medicinal Plants Towards Human Oral Pathogen
2016 (4):
88-98.
摘要
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Oral diseases continue to be a major health problem worldwide. The increasing failure of chemotherapeutics and antibiotics
resistance exhibited by pathogenic micro-organisms has led to the screening of several medicinal plants for their potential
anticariogenic activity. In the present study, in vitro anticariogenic potential of the organic solvents of 20 plant leaves was
evaluated by using five oral pathogen, Lactobacillus acidophilus, Lactobacillus casei, Staphylococcus aureus, Streptococcus mutans
and Candida albicans. Agar well diffusion method and minimum inhibitory concentration were used for this purpose. Plant
extracts exhibited varying degree of inhibited on growth of oral pathogen between hexane and ethyl acetate extracts is highly
potential. Maximum activity show hexane (15mm) and ethyl acetate (16mm) extracts of Piper betle against S. mutans. The MIC
of crude extract of ethyl acetate of Syzygium rubicundum against L. acidophilus was 0.12 mg/mL and ethyl acetate extract of Piper
betle was 1 mg/mL and 0.25 mg/mL respectively for S. mutans and L. casei. The preliminary phytochemical analysis of crude
extract of ethyl acetate of P. betle prsent the Phenolic compound and Alkaloid. Clear zone of inhibition against S. mutans located
on TLC plate when bioautography performed using ethyl acetate extract of P. betle. The bioactive compound was separated
from the crude ethyl acetate extract by using TLC technique. Further, spectroscopy analysis are requiring for determination of
structure of bioactive compound. The finding may be useful in the development of drugs against oral pathogen.
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