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本期目录

    2024年, 第19卷, 第2期 刊出日期:2024-04-28 上一期    下一期
    Study on the mechanism of Euphorbia fischeriana Steud.-Jujubae Fructus in the treatment of hepatocirrhosis based on network pharmacology
    Yanqiong Luo, Bo Hong, Ronghong Liu, Yu Zou, Yujiao Hou, Wenjing Li
    2024 (2):  51-65. 
    摘要 ( 122 )   PDF(6070KB) ( 271 )  
    The active components, targets, and pathways of Euphorbia fischeriana Steud.-Jujubae Fructus in treating hepatocirrhosis and the mechanism of action were explored by means of network pharmacology. Firstly, the active components and related targets of Jujubae Fructus were screened by TCMSP database and standardized by Uniprot database. The compounds of Euphorbia fischeriana Steud. were obtained by searching the literature and finally screened by PubChem database, Swiss ADME, and SwissTargetPrediction. Hepatocirrhosis targets were obtained through Genecards database, PPI network analysis was conducted on common targets of Euphorbia fischeriana Steud.-Jujubae Fructus and hepatocirrhosis by using String database, GO enrichment analysis and KEGG pathway enrichment analysis was conducted through Metascape database by using intersection targets of Euphorbia fischeriana Steud.-Jujubae Fructus and hepatocirrhosis, and the results were drawn by using Weishengxin online drawing platform. Then, the network of drug-compound-target-pathway was constructed by the software of Cytoscape3.8.0. Finally, the above results were verified by molecular docking. 47 active compounds from Euphorbia fischeriana Steud.-Jujubae Fructus were screened out, which had 38 common targets, 162 intersection targets, and 340 signal pathways with hepatocirrhosis, mainly involving hepatitis C, JAK-STAT signal pathway and AGE-RAGE signal pathway. Targets, such as MAPK1, AKT1, TNF, JUN, IL6 and PTGS2, play important roles in the treatment. The findings suggested that the main active ingredients of Euphorbia fischeriana Steud.-Jujubae Fructus in treating hepatocirrhosis are quercetin, scopolamine, physcion, 7-deoxyrangduin, 17-Hydroxyjolkinolide A, etc. Molecular docking results showed that the main active components and core targets might have a good binding capacity. This study preliminarily explored the potential mechanism of Euphorbia fischeriana Steud.-Jujubae Fructus in treating hepatocirrhosis and provided a theoretical basis for the clinical application of Euphorbia fischeriana Steud.-Jujubae Fructus.

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    Analysis of plant resources and diversity in Shennongjia Area of Hubei Province, China#br# #br#
    Terigen Bao , Min Li , Jingming Jia, Anhua Wang
    2024 (2):  66-87. 
    摘要 ( 64 )   PDF(45732KB) ( 24 )  
    Shennongjia Area is located in northwest of Hubei Province with Shennongding, the highest peak (3105.4 m above sea level) in central China. The unique geographical location and complex terrain of this region make it rich in plant resources. After field investigation, literature review, and specimen identification, the 7th Shenyang Pharmaceutical University Chinese Medicine Resources Scientific Expedition Team studied the plant resources and diversity of Shennongjia Area. 454 species of vascular plants belonging to 106 families and 275 genera were collected from July to August in 2013. The dominant families are Lamiaceae, Ranunculaceae, Rosaceae, and Asteraceae, with 20, 21, 37 and 48 species respectively. At the genus level, Rubus is the dominant one with 11 species. 3 species of national first-class protective plants, 13 species of “Huan yang yao” and 36 species of “Qi yao” were collected. In all, our research has updated the plant recources and diversity in Shennongjia Area. Furthermore, by putting forward practical and meaningful suggestions on strengthening the protection and utilization of plant resources in Shennongjia Area, our research will help to protect the diverse ecosystem there.

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    Analysis of plant resources and diversity in the southeast area of Taihang Mountains#br# #br#
    Junpeng Lin, Jingming Jia, Anhua Wang
    2024 (2):  88-98. 
    摘要 ( 69 )   PDF(941KB) ( 97 )  
    Taihang Mountains are situated between Shanxi Province and the North China Plain, spanning Beijing, Hebei, Shanxi, and Henan provinces and cities. The mountains extend from northeast to southwest for over 400 km, naturally deviding the second step from the third one in China. The southeastern area of Taihang Mountains specifically refers to Changzhi City and Jincheng Administrative Region of Shanxi Province. Given Shanxi Province’s robust development plans for the southeast area of Taihang Mountains, the medicinal plant resources in this area will be affected. Therefore, it is imperative and urgent to conduct a comprehensive investigation and study on the medicinal plant resources in the southeast area of Taihang Mountains. By means of field investigation, literature review, and specimen identification, the plant resources and diversity of two counties in the southeast of Taihang Mountains were evaluated. The findings revealed 234 plants species across 172 genera in 70 families, primarily comprising angiosperms. The families with more species included Compositae, Leguminosae, Rosaceae, Labiatae, Ranunculaceae. Among the genera, those with more species were Cynanchum, Selaginella, Clematis, Thalictrum, and Rhamnus. A total of 114 medicinal plants were identified, constituting 48.72% of the total. Regarding medicinal parts, the concentration is in roots and rhizomes, followed by whole plants and fruits. On the basis of investigation and study, some suggestions on the development, utilization, and protection of medicinal plant resources in southeast Taihang Mountains were made. These suggestions provide valuable insights for the study on medicinal plant resources and vegetation in the southeast of Taihang Mountains, serving as a scientific basis for the protection and sustainable utilization of wild medicinal plant resources.
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    Chemical constituents and pharmacological effects of Croton crassifolius#br# #br#
    Luyan Yang, Yibo Wang, Xinyao Wang, Xiaoxia Xu , Yunpeng Yang, Meng Zhang, Yu Chen
    2024 (2):  99-114. 
    摘要 ( 78 )   PDF(970KB) ( 74 )  
    Croton crassifolius (CC) is a kind of traditional Chinese medicine rich in terpenoids, with among which diterpene species are the most. CC had biological activities in the treatment of cancer, inflammation, ulcerative colitis, osteoporosis and Alzheimer’s disease. This study reviews the chemical compositions and pharmacological activities of CC to provide reference for further research.

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