亚洲传统医药

本期目录

2023年, 第18卷, 第3期　刊出日期：2023-06-27 上一期    下一期

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Mechanism of Cinnamomum camphora essential oil for analgesia based on gas chromatography-mass spectrometry integrated network pharmacology Nianyun Yang 2023 (3):  87-97.  摘要 ( 434 )   PDF(4328KB) ( 241 )   This study aims to explore the analgesic ingredients and mechanism of Cinnamomum camphora essential oil (CCEO). The constituents in CCEO were characterized qualitatively by gas chromatography-mass spectrometry. Targets related to active ingredients were collected by PubChem and Swiss Target Prediction. Targets related to pain were screened by TTD and OMIM database, and compound-target network was established by Cytoscape software. Gene ontology (GO) function and Kyoto encyclopedia of genes and genomes (KEGG) pathway enrichment analysis of targets were carried out by DAVID database. Protein-protein interaction (PPI) network was established and analyzed by STRING database. Molecular docking method was used to verify the interaction between main components and relevant core targets. A total of 13 compounds were identified in CCEO, and 58 related targets were predicted. GO function enrichment analysis revealed that the selected targets were mainly involved in biological processes such as chemical synaptic transmission and molecular function such as neurotransmitter receptor activity; 24 signal pathways were screened by KEGG pathway enrichment analysis, including neuroactive ligand-receptor interaction, retrograde endocannabinoid signaling and calcium signaling pathway. Docking results showed that the main constituents had certain affinities with the key targets. The active ingredients in CCEO regulated multiple signaling pathways to ameliorate pain through AR, ACHE, ESR1, GABRG2, PTGS2 and PPARγ. 相关文章 | 计量指标

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The main chemical constituents from Piper amalago: A review of its phytochemistry Zhaojun Zhang, Zhikang Duan, Xiaoxiao Huang 2023 (3):  98-115.  摘要 ( 301 )   PDF(1591KB) ( 202 )   Piper amalago (P. amalago) is a traditional medicine in Brazil for the treatment of leishmanial. Owing to its rare occurrence and potent pharmacological activities, efforts have been devoted to the identification of its diverse constituents, especially terpenoids. Researchers have found that the major constituents of P. amalago were amides, monoterpenes, norisoprenoids, sesquiterpenes, aliphatic hydrocarbons and aromatic hydrocarbons. The amides show anxiolytic, anti-inflammatory, antileishmanial and antinociceptive activity. This review summarizes the research progress of the structural diversity and pharmacological activities of P. amalago. 相关文章 | 计量指标

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Chemical constituents and biological activities of Artemisiae argyi Zhinan Leng, Yi’an Shi, Shuo Wang, Yunpeng Yang, Ji Wu, Yu Chen 2023 (3):  116-136.  摘要 ( 361 )   PDF(1172KB) ( 246 )   Artemisiae argyi (A. argyi) is a traditional medical plant, with medicinal and economic value. It has been used to treat diseases for more than 2000 years, and its application has been expanded in recent years with the in-depth research on the chemical composition and pharmacology. It is mainly used clinically for the treatment of “cold pain in the abdomen, cold clotting in the menstrual channels, cold infertility in the uterus, fetal movement, vomiting blood, epistaxis, pus and blood dysentery, and external treatment of itchy skin” and other symptoms. This paper reviews the research on the biological activity and chemical composition of A. argyi by scholars in recent decades. 相关文章 | 计量指标