摘要：
Depression is a psychiatric disorder characterized by persistent low mood and anhedonia as core symptoms. Its global prevalence continues to rise, imposing a substantial disease burden on society. The pathological mechanisms encompass multiple facets, including neuroinflammation, impaired neuroplasticity and hyperactivation of the hypothalamic-pituitary-adrenal (HPA) axis, and imbalance of monoamine neurotransmitters. Active ingredients derived from traditional Chinese medicine (TCM) demonstrate unique therapeutic value in antidepressant treatmentowing to their multi-target, multi-pathway integrative modulatory advantages. This review systematically summarizes the molecular pathways underlying the antidepressant effects of TCM active ingredients, with a focus on neuroinflammation intervention and other related mechanisms, and outlines the mechanisms of classical antidepressant TCM formulations, providing a theoretical basis for modern research on TCM-based antidepressant therapy.
Yunkun Zhang, Shuhua Yang, Yizhen Chen, Lerong Li, Ruizi Ma, Xin Wu.
Research progress on the antidepressant effects of active components in traditional Chinese medicine via neuroinflammation and related mechanisms: a review
[J]. 亚洲传统医药, 2026, 21(3): 251-274.
Yunkun Zhang, Shuhua Yang, Yizhen Chen, Lerong Li, Ruizi Ma, Xin Wu.
Research progress on the antidepressant effects of active components in traditional Chinese medicine via neuroinflammation and related mechanisms: a review
[J]. Asian Journal of Traditional Medicines, 2026, 21(3): 251-274.
