亚洲传统医药
亚洲传统医药

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›› 2010, Vol. 5 ›› Issue (6): 226-229.

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Amentoflavone and the extracts from Selaginella tamariscina and their anticancer activity

  

  • 收稿日期:2010-05-17 修回日期:2010-10-25 出版日期:2010-12-20 发布日期:2010-12-20

Amentoflavone and the extracts from Selaginella tamariscina and their anticancer activity

Ying Jing 1; Guogang Zhang 1 *; Enlong Ma 2; Hongmei Zhang 1; Jin Guan 3; Jie He 1   

  1. 1. School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, China 2. School of Life Science And Biopharmceutics, Shenyang Pharmaceutical University, Shenyang 110016, China 3. College of Applied Chemistry, Shenyang Institute of Chemical Technology, Shenyang 110142, China
  • Received:2010-05-17 Revised:2010-10-25 Online:2010-12-20 Published:2010-12-20
  • Contact: Guogang Zhang

Abstract: The extracts and amentoflavone were extracted from the plant of Selaginella tamariscina. The extracts mainly contained biflavonoids. The structure of amentoflavone was elucidated by spectral examinations. Amentoflavone and the extracts were screened against five cancer cells, including HeLa (human cervical carcinoma cells), BEL-7402 (human hepatoma carcinoma cells), MCF-7 (human breast cancer cells), PANC-1 (human pancreatic cancer cells) and HL-60 (human leukemia cells). The anticancer activity were determined by means of MTT assay and Trypan Blue cytometry. Assays in vitro showed that they were effective to inhibit the proliferation of HL-60, MCF-7, HeLa, BEL-7402, PANC-1 and had reliable activity against HL-60.

Key words: amentoflavone, extracts, Selaginella tamariscina, anticancer activity

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